ID A0A0F5K438_9BURK Unreviewed; 298 AA.
AC A0A0F5K438;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=2-dehydropantoate 2-reductase {ECO:0000256|ARBA:ARBA00019465};
DE EC=1.1.1.169 {ECO:0000256|ARBA:ARBA00013014};
DE AltName: Full=Ketopantoate reductase {ECO:0000256|ARBA:ARBA00032024};
GN ORFNames=WM40_04730 {ECO:0000313|EMBL:KKB64700.1};
OS Robbsia andropogonis.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Robbsia.
OX NCBI_TaxID=28092 {ECO:0000313|EMBL:KKB64700.1, ECO:0000313|Proteomes:UP000033618};
RN [1] {ECO:0000313|EMBL:KKB64700.1, ECO:0000313|Proteomes:UP000033618}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ICMP2807 {ECO:0000313|EMBL:KKB64700.1,
RC ECO:0000313|Proteomes:UP000033618};
RA Lopes-Santos L., Castro D.B., Ottoboni L.M., Park D., Weirc B.S.,
RA Destefano S.A.;
RT "Draft Genome Sequence of Burkholderia andropogonis type strain ICMP2807,
RT isolated from Sorghum bicolor.";
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH;
CC Xref=Rhea:RHEA:16233, ChEBI:CHEBI:11561, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:15980, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC EC=1.1.1.169; Evidence={ECO:0000256|ARBA:ARBA00000784};
CC -!- PATHWAY: Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-
CC pantoate from 3-methyl-2-oxobutanoate: step 2/2.
CC {ECO:0000256|ARBA:ARBA00004994}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKB64700.1}.
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DR EMBL; LAQU01000003; KKB64700.1; -; Genomic_DNA.
DR RefSeq; WP_046152274.1; NZ_LAQU01000003.1.
DR AlphaFoldDB; A0A0F5K438; -.
DR STRING; 28092.WM40_04730; -.
DR PATRIC; fig|28092.6.peg.1122; -.
DR OrthoDB; 8555723at2; -.
DR UniPathway; UPA00028; UER00004.
DR Proteomes; UP000033618; Unassembled WGS sequence.
DR GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0015940; P:pantothenate biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR013332; KPR_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR21708:SF42; 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR PANTHER; PTHR21708; PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Pantothenate biosynthesis {ECO:0000256|ARBA:ARBA00022655};
KW Reference proteome {ECO:0000313|Proteomes:UP000033618}.
FT DOMAIN 9..147
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 175..291
FT /note="Ketopantoate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08546"
SQ SEQUENCE 298 AA; 31614 MW; F8B1A6C5B784AD58 CRC64;
MTISENLSIA LVGPGAIGVT VAAALHEVGR TPVICGRTAH EQLILRFDSE RVVIPGPVLT
DPANVKTRFD LVFIAVKATQ IDAAAAWLPA LCHADTVVCV LQNGVEQTTL FHARLPRNPI
VPSVVWFPAQ RESDGSVWLR NAPRLVVPDD PAAGIVRAAL HGTRCAVEAV SDFPTVAWRK
LLQNAVAGLM VLTGRRAGMF SRPDIAALAL AYARECLEVA QAAGAKLSDQ TAQEVVEGFR
NAPPDLGTSI LADRLAGRPL EWDIRNNIIR RVGQTHGVPT PISDVIVPLL AAGSDGPG
//
