ID A0A0F5MQ29_9RICK Unreviewed; 1097 AA.
AC A0A0F5MQ29;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN Name=addA {ECO:0000313|EMBL:KKB96880.1};
GN ORFNames=SZ25_00026 {ECO:0000313|EMBL:KKB96880.1};
OS Candidatus Arcanobacter lacustris.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales; Arcanobacter.
OX NCBI_TaxID=1607817 {ECO:0000313|EMBL:KKB96880.1, ECO:0000313|Proteomes:UP000033358};
RN [1] {ECO:0000313|EMBL:KKB96880.1, ECO:0000313|Proteomes:UP000033358}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCGC AAA041-L04 {ECO:0000313|EMBL:KKB96880.1,
RC ECO:0000313|Proteomes:UP000033358};
RA Martijn J., Schulz F., Zaremba-Niedzwiedzka K., Viklund J.,
RA Stepanauskas R., Andersson S.G.E., Horn M., Guy L., Ettema T.J.G.;
RT "Single cell genomics of a rare environmental alphaproteobacterium provides
RT unique insights into Rickettsiaceae evolution.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKB96880.1}.
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DR EMBL; JYHA01000007; KKB96880.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0F5MQ29; -.
DR PATRIC; fig|1607817.3.peg.26; -.
DR Proteomes; UP000033358; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014151; DNA_helicase_AddA.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR02784; addA_alphas; 1.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000033358}.
FT DOMAIN 1..453
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 470..752
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 18..25
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1097 AA; 125830 MW; 15AF1E6AD3692CA5 CRC64;
MTNQFIASDP NHSVWVSASA GTGKTKILTD RVLRLLLDGN HPSKILCITF TKAASAEMSN
RINNELASWA VLDQENLIQK LTTLTGKTPE SNNITIARRL FSLILDSNDG IKIQTIHSFC
QSILKRFPIE ANIANNYKII DEATSETFLQ EAKMQILEKE DLKEIIQYIS WQLYETSFDE
LIREIIAGKS EISNILASYD FSVESIIEEL AKRFNIDQDD SNLEDYIRDN RNELVLLLDI
LPPAKENELY NLLETNIHDY GSLKNIFLTK ENTPRKLVSK ANSIKFPQAE ELVAKWQELI
LTHQEKLNSL KIIKHTQCFL MLAKSFIDQY QLLKNNKSLL DYGDLISITN NLLTNNNSRD
WVLYKLDGGI DHILVDEAQD TSKEQWQIIE SLCAEFFASQ GLESNNRTLF VVGDEKQSIF
SFQGADPKNF NEMHRYFNQF VENINLETCY RSTAPILKLV DEIFKSPELA TAVTANKSEI
IHRSFREKQA GSVTLWPLVQ VETKENNEHW LLPIERKIKH SPSLKLAQLI ATNIEDWISN
KKILKSKNRP ITEGDIMILV RRRNELTDNL VKELKKRNIK VAGIDRMKIA DNIAIMDLMA
LADFLLLQSD DLSLACVLKS PLFNLSEENL MELAIGRDST LWHSLKSNPK HLEVYNSLKE
LIYRAKNNSP FALFSYIIEV IDGRKKLCAR LGEEVNDPID EFINLSLSFE KDNIPSLQNF
VKWFRSSTID IKRDLESSLG QIRIMTIHAS KGLQAPIVIL ADTVSVPNSF DKLIYTDLVI
WPGKIANYNK YCLSLRAKKS KEEYNEYLRL LYVALTRAED QLIICGYKNS QQISNNCWYR
IIESTMKTIA KEFIFEVGND FTPYLTNQAA YVIESDQLTD VINNDTNNKI DNISLSLPEF
LFRDPPKEPL PLKQIIASTK ISTDNQFNYS SMGHNELKKG NIIHKLLEFS SIIQKDTNTI
HKFINQYGAD LDQATKYTIY NQYIKLLETK EFEIIFGPNS KAEASVTGVV GDKFIISGKI
DRLVILEDEV MIIDYKSDSI VAKSEDEVHP NYLQQMASYQ MLMKEIYPDK KISCWLIWTN
NASLMSLSQS LIKYLPK
//
