ID A0A0F5MTV4_9MYCO Unreviewed; 300 AA.
AC A0A0F5MTV4;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Mechanosensitive ion channel family protein {ECO:0000313|EMBL:TXI48761.1};
DE SubName: Full=Mechanosensitive ion channel protein MscS {ECO:0000313|EMBL:KKB98039.1};
GN ORFNames=E6Q54_23415 {ECO:0000313|EMBL:TXI48761.1}, WR43_16420
GN {ECO:0000313|EMBL:KKB98039.1};
OS Mycolicibacter arupensis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacter.
OX NCBI_TaxID=342002 {ECO:0000313|EMBL:KKB98039.1, ECO:0000313|Proteomes:UP000034416};
RN [1] {ECO:0000313|Proteomes:UP000034416}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GUC1 {ECO:0000313|Proteomes:UP000034416};
RA Greninger A.L., Cunningham G., Chiu C.Y., Miller S.;
RT "Genome sequence of Mycobacterium arupense GUC1.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KKB98039.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GUC1 {ECO:0000313|EMBL:KKB98039.1};
RA Greninger A.L., Cunningham G., Chiu C.Y., Miller S.;
RT "Genome sequence of Mycobacterium arupense strain GUC1.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:TXI48761.1, ECO:0000313|Proteomes:UP000321797}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bin_29_2 {ECO:0000313|EMBL:TXI48761.1};
RA Stamps B.W., Spear J.R.;
RT "Metagenome Assembled Genomes from an Advanced Water Purification
RT Facility.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKB98039.1}.
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DR EMBL; LASW01000090; KKB98039.1; -; Genomic_DNA.
DR EMBL; SSGD01000178; TXI48761.1; -; Genomic_DNA.
DR RefSeq; WP_046190664.1; NZ_VUJZ01000001.1.
DR AlphaFoldDB; A0A0F5MTV4; -.
DR STRING; 342002.BST15_00185; -.
DR PATRIC; fig|342002.3.peg.1242; -.
DR OrthoDB; 4638917at2; -.
DR Proteomes; UP000034416; Unassembled WGS sequence.
DR Proteomes; UP000321797; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0008381; F:mechanosensitive monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049278; MS_channel_C.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR InterPro; IPR045276; YbiO_bact.
DR PANTHER; PTHR30460:SF0; MODERATE CONDUCTANCE MECHANOSENSITIVE CHANNEL YBIO; 1.
DR PANTHER; PTHR30460; UNCHARACTERIZED; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR Pfam; PF21082; MS_channel_3rd; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 27..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 76..97
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 126..194
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT DOMAIN 202..288
FT /note="Mechanosensitive ion channel MscS C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21082"
SQ SEQUENCE 300 AA; 32353 MW; 3D9AC4ABF917D11F CRC64;
MTLAFSPGQR WSELWRGEIG EWVITKGLRI VLLLIGAVLA SRFITWTAQR VTRRLEHGFA
TSDALVRSEA SKHRQAVASV ISWVSVVLLC VVVGVQITTI LDIPIGSLVG PAAVIGGAIG
FGAQKLVQDL LSGFFIITEK QYGFGDLVQL SMTGAPTEAL GTVEEVTLRV TKLRTPNGEV
FTVPNGNIVR SLNLSKDWAR AVVDIPVPTS ADLTRVNEVL HQVCEHAREA DAPLRDLLLD
QPSMMGVESL EVGVVNLRMV ARTLPGKQFE VGRRLRIQVV QALASVGVAA AGEVKPVQTP
//
