ID A0A0F5MWF2_9MYCO Unreviewed; 369 AA.
AC A0A0F5MWF2;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Steroid delta-isomerase {ECO:0000313|EMBL:KKB98929.1};
GN ORFNames=WR43_12010 {ECO:0000313|EMBL:KKB98929.1};
OS Mycolicibacter arupensis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacter.
OX NCBI_TaxID=342002 {ECO:0000313|EMBL:KKB98929.1, ECO:0000313|Proteomes:UP000034416};
RN [1] {ECO:0000313|Proteomes:UP000034416}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GUC1 {ECO:0000313|Proteomes:UP000034416};
RA Greninger A.L., Cunningham G., Chiu C.Y., Miller S.;
RT "Genome sequence of Mycobacterium arupense GUC1.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKB98929.1}.
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DR EMBL; LASW01000050; KKB98929.1; -; Genomic_DNA.
DR RefSeq; WP_046189826.1; NZ_MVHH01000014.1.
DR AlphaFoldDB; A0A0F5MWF2; -.
DR STRING; 342002.BST15_09385; -.
DR PATRIC; fig|342002.3.peg.200; -.
DR OrthoDB; 3174087at2; -.
DR Proteomes; UP000034416; Unassembled WGS sequence.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000313|EMBL:KKB98929.1}.
FT DOMAIN 14..269
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 369 AA; 40296 MW; FBDE0AFB486DE28A CRC64;
MGDPSLTTEL GRVLVTGGSG FVGTNFVKTL LERGYQVRSF DRAPSSLPDH PNLEKLEGDI
CDPATVAAAV AGIDTVFHTA ALIDLQGGAK VTDEIRRRSF AVNVDGTKNL VQAGQRAGVK
RFVYTASNSV VMGGKAISGG NETMAYTTKF NDLYTETKVV AEKFVLGENG VDGMLTCSIR
PSGIWGNGDQ TMFRILFERV VAGQVKVLVG GKHAKLDNSY VHNLIHGFIL AAQHLVPGGS
APGQAYFIND GEPINMFEFA RPVVTACGEP WPRIRVSGRM VRDIMAVWQW LHFRFGLPKP
PLEPGPVERL YLDNYFSIDK AGRDLGYQPL FTTEQAMADC LPYYKKLFEQ VKAEAHPHLA
TVVAEPHPE
//
