ID   A0A0F5N2I8_9MYCO        Unreviewed;      1112 AA.
AC   A0A0F5N2I8;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=TM0106 family RecB-like nuclease {ECO:0008006|Google:ProtNLM};
GN   ORFNames=WR43_01435 {ECO:0000313|EMBL:KKC01206.1};
OS   Mycolicibacter arupensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycolicibacter.
OX   NCBI_TaxID=342002 {ECO:0000313|EMBL:KKC01206.1, ECO:0000313|Proteomes:UP000034416};
RN   [1] {ECO:0000313|Proteomes:UP000034416}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GUC1 {ECO:0000313|Proteomes:UP000034416};
RA   Greninger A.L., Cunningham G., Chiu C.Y., Miller S.;
RT   "Genome sequence of Mycobacterium arupense GUC1.";
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KKC01206.1}.
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DR   EMBL; LASW01000003; KKC01206.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0F5N2I8; -.
DR   STRING; 342002.BST15_02960; -.
DR   PATRIC; fig|342002.3.peg.523; -.
DR   Proteomes; UP000034416; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd17934; DEXXQc_Upf1-like; 1.
DR   CDD; cd18808; SF1_C_Upf1; 1.
DR   Gene3D; 3.90.320.10; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR045055; DNA2/NAM7-like.
DR   InterPro; IPR041679; DNA2/NAM7-like_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011604; PDDEXK-like_dom_sf.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   InterPro; IPR019993; RecB_nuclease_TM0106_put.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR047187; SF1_C_Upf1.
DR   InterPro; IPR038720; YprB_RNase_H-like_dom.
DR   NCBIfam; TIGR03491; TM0106 family RecB-like putative nuclease; 1.
DR   PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR   PANTHER; PTHR10887:SF525; HELICASE SENATAXIN-RELATED; 1.
DR   Pfam; PF13087; AAA_12; 1.
DR   Pfam; PF13604; AAA_30; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   Pfam; PF13482; RNase_H_2; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022806};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022806};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022806}.
FT   DOMAIN          100..215
FT                   /note="PD-(D/E)XK endonuclease-like"
FT                   /evidence="ECO:0000259|Pfam:PF12705"
FT   DOMAIN          314..494
FT                   /note="YprB ribonuclease H-like"
FT                   /evidence="ECO:0000259|Pfam:PF13482"
FT   DOMAIN          902..1079
FT                   /note="DNA2/NAM7 helicase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13087"
FT   REGION          786..810
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1112 AA;  123818 MW;  CF19D712FDDCB9AA CRC64;
     MLTPSKITAW LDCAHYLTLR NQVDGGTLPQ PNSTFGEFAR LLLDKGLQHE EQCLAEYQAN
     GKSVLEIPGR YERESFETWV TRLGDPFNDG WDVIYQMPFI HDGVRGIADF LVRTSDGRYE
     PVDAKLARSE AKPGHVLQLC FYADAIEAFT GIRPRNMHLW LGSGKQQTLR VDDFSPYWRR
     LRKQLSKTLT AGPEAGTVPL PCTHCDFCEF RTLCDKQWHD EGALNLVAGI RQPETVTFGA
     AGIANMTALA QPRTSVVGIG PRRLERLTEQ ARLQLQAALL ADDDSPPFQL VESGEDPVWG
     HGFEELPRPD DGDVFLDFEG HPFWRVETGL FFLFGLLERG EDGQWRYREW WAHDIQAEAT
     AVSDLIDYLA QRRAAFPDMH VYHYNHTERS SLVTLTEKHN VAQRALTALI DTGFFVDLLL
     VARNSIQVGT ESYGLKALER LTSFQRSHDI DKGAGAVLQY EQFMKDRDSA ELASIAVYNE
     DDVRATMALR DWLVAHRPTD LAWRDAVLEP DPGLPELDEH VERLHAFAVD TPEYLLGDLL
     GYWRREWFAY IGPKMAKLEG DTTALHDDPE ALTELHCLGE VERLGKRGTP ITPGMRFSFP
     PQSLERFPYD GGSVMFVDAE GQRFYPSFEN LERSSCTLDL VWNTALQEVG VLPSVVLLHD
     WVEPKPKPQT MSGFADQLLD GADINPVTMA LLRRDPPRFT AGGEPVGGVF TDDLADMTRW
     VTHLDNSYAA IQGPPGAGKT YSAAHLIHAL ILAGRRVGVT ATTHHAIDNV LEKVVQLFRD
     NGDTAKLNAV KKPKSGSPSV PDGTRAGSSK DCARRDVNLV AGTTWLFASK EMCDSPVDVL
     LVDEAGQLSL ADALAASVAS RNVVLLGDPL QLPQVTQASH PNNSGRSVLE HILGTDETLP
     GDRGVFLSKT FRMHPDVCRF ISDEIYAGRL THNASCEQQS TVAGTGLRWL KAEHRGNSTS
     SSEEAELIAT EIARLVGTNW TNEKGDKKFL TAEDFMVVAP FNDQVRAIRD RLNAEVLTRN
     VAVGTVDKFQ GREAAVVFFS MTTSAGEDIS RGADFLFSRN RLNVAISRAR CLAYLVCTEE
     LLNTRARNVE DMRLIATLNS VVEYAQRRHH PE
//