ID A0A0F5N4W4_9MYCO Unreviewed; 390 AA.
AC A0A0F5N4W4;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:ORW17790.1};
GN ORFNames=AWC17_11675 {ECO:0000313|EMBL:ORW17790.1};
OS Mycobacterium nebraskense.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=244292 {ECO:0000313|EMBL:ORW17790.1, ECO:0000313|Proteomes:UP000193781};
RN [1] {ECO:0000313|EMBL:ORW17790.1, ECO:0000313|Proteomes:UP000193781}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44803 {ECO:0000313|EMBL:ORW17790.1,
RC ECO:0000313|Proteomes:UP000193781};
RA Tarcisio F., Conor M., Antonella G., Elisabetta G., Giulia F.S., Sara T.,
RA Anna F., Clotilde B., Roberto B., Veronica D.S., Fabio R., Monica P.,
RA Olivier J., Enrico T., Nicola S.;
RT "The new phylogeny of the genus Mycobacterium.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORW17790.1}.
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DR EMBL; LQPH01000150; ORW17790.1; -; Genomic_DNA.
DR RefSeq; WP_046186586.1; NZ_LQPH01000150.1.
DR AlphaFoldDB; A0A0F5N4W4; -.
DR STRING; 244292.ABW17_04650; -.
DR OrthoDB; 9764638at2; -.
DR Proteomes; UP000193781; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43365; BLR7806 PROTEIN; 1.
DR PANTHER; PTHR43365:SF1; STEROID 3-KETOACYL-COA THIOLASE FADA6; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:ORW17790.1}.
FT DOMAIN 6..259
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 268..389
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 92
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 346
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 376
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 390 AA; 40458 MW; 6B227F5FEDA03712 CRC64;
MNRDAVIVGA VRTPIGKGKP SGALHDVLPA DLLAHSLREL VTRSGVDPAQ IDDVIAGAVA
QVGDQAVNIA RNALLGAGFP ESVPGVTIDR QCGSSQQAIS FAAQGVLSGA YDLVVAAGVE
SMGRVPMGTS VLPGSNPFGD DMTRRYPDGL VPQGISAELI AARWGFSRTQ LDEFSAGSHD
KAARATKDGL FDNELIPIAG LVTDEFIRPG TTVETLAGLQ PAFYSEAMKA RFPQIDWSIT
AGNSSPLSDG SAAVLITTSE VAKKLGLRPL ARIHTTTVVG SDPLYMLTGV IPATEKVLHR
AGLTLADIDL FEVNEAFAPV VLAWAQDTGA DLAKTNVNGG AIAIGHPLGA SGARIMTTLV
NALEQRGGRY GLQTMCEGGG MANATIIERL
//
