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Database: UniProt
Entry: A0A0F5N9Q6_9MYCO
LinkDB: A0A0F5N9Q6_9MYCO
Original site: A0A0F5N9Q6_9MYCO 
ID   A0A0F5N9Q6_9MYCO        Unreviewed;       701 AA.
AC   A0A0F5N9Q6;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   RecName: Full=Vitamin B12-dependent ribonucleotide reductase {ECO:0000256|RuleBase:RU364064};
DE            EC=1.17.4.1 {ECO:0000256|RuleBase:RU364064};
GN   ORFNames=AWC17_07500 {ECO:0000313|EMBL:ORW20894.1};
OS   Mycobacterium nebraskense.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=244292 {ECO:0000313|EMBL:ORW20894.1, ECO:0000313|Proteomes:UP000193781};
RN   [1] {ECO:0000313|EMBL:ORW20894.1, ECO:0000313|Proteomes:UP000193781}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44803 {ECO:0000313|EMBL:ORW20894.1,
RC   ECO:0000313|Proteomes:UP000193781};
RA   Tarcisio F., Conor M., Antonella G., Elisabetta G., Giulia F.S., Sara T.,
RA   Anna F., Clotilde B., Roberto B., Veronica D.S., Fabio R., Monica P.,
RA   Olivier J., Enrico T., Nicola S.;
RT   "The new phylogeny of the genus Mycobacterium.";
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the reduction of ribonucleotides to
CC       deoxyribonucleotides. May function to provide a pool of
CC       deoxyribonucleotide precursors for DNA repair during oxygen limitation
CC       and/or for immediate growth after restoration of oxygen.
CC       {ECO:0000256|RuleBase:RU364064}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-
CC         diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-
CC         diphosphate; Xref=Rhea:RHEA:23252, Rhea:RHEA-COMP:10698, Rhea:RHEA-
CC         COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058,
CC         ChEBI:CHEBI:57930, ChEBI:CHEBI:73316; EC=1.17.4.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000206,
CC         ECO:0000256|RuleBase:RU364064};
CC   -!- COFACTOR:
CC       Name=adenosylcob(III)alamin; Xref=ChEBI:CHEBI:18408;
CC         Evidence={ECO:0000256|ARBA:ARBA00001922,
CC         ECO:0000256|RuleBase:RU364064};
CC   -!- PATHWAY: Genetic information processing; DNA replication.
CC       {ECO:0000256|ARBA:ARBA00005160}.
CC   -!- SIMILARITY: Belongs to the ribonucleoside diphosphate reductase class-2
CC       family. {ECO:0000256|ARBA:ARBA00007405, ECO:0000256|RuleBase:RU364064}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ORW20894.1}.
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DR   EMBL; LQPH01000129; ORW20894.1; -; Genomic_DNA.
DR   RefSeq; WP_046184936.1; NZ_LQPH01000129.1.
DR   AlphaFoldDB; A0A0F5N9Q6; -.
DR   STRING; 244292.ABW17_20990; -.
DR   OrthoDB; 9762933at2; -.
DR   UniPathway; UPA00326; -.
DR   Proteomes; UP000193781; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR   GO; GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:UniProtKB-EC.
DR   GO; GO:0009263; P:deoxyribonucleotide biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniPathway.
DR   CDD; cd02888; RNR_II_dimer; 1.
DR   Gene3D; 3.20.70.20; -; 1.
DR   InterPro; IPR005144; ATP-cone_dom.
DR   InterPro; IPR000788; RNR_lg_C.
DR   InterPro; IPR013509; RNR_lsu_N.
DR   InterPro; IPR013344; RNR_NrdJ/NrdZ.
DR   InterPro; IPR008926; RNR_R1-su_N.
DR   NCBIfam; TIGR02504; NrdJ_Z; 1.
DR   PANTHER; PTHR43371:SF1; RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE; 1.
DR   PANTHER; PTHR43371; VITAMIN B12-DEPENDENT RIBONUCLEOTIDE REDUCTASE; 1.
DR   Pfam; PF03477; ATP-cone; 1.
DR   Pfam; PF02867; Ribonuc_red_lgC; 2.
DR   Pfam; PF00317; Ribonuc_red_lgN; 1.
DR   PRINTS; PR01183; RIBORDTASEM1.
DR   SUPFAM; SSF51998; PFL-like glycyl radical enzymes; 1.
DR   SUPFAM; SSF48168; R1 subunit of ribonucleotide reductase, N-terminal domain; 1.
DR   PROSITE; PS51161; ATP_CONE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00492};
KW   Cobalamin {ECO:0000256|ARBA:ARBA00022628, ECO:0000256|RuleBase:RU364064};
KW   Cobalt {ECO:0000256|ARBA:ARBA00023285, ECO:0000256|RuleBase:RU364064};
KW   Deoxyribonucleotide synthesis {ECO:0000256|ARBA:ARBA00023116};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   DNA synthesis {ECO:0000256|ARBA:ARBA00022634,
KW   ECO:0000256|RuleBase:RU364064};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00492};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU364064}.
FT   DOMAIN          12..104
FT                   /note="ATP-cone"
FT                   /evidence="ECO:0000259|PROSITE:PS51161"
SQ   SEQUENCE   701 AA;  74853 MW;  2D75A0DD97A11D25 CRC64;
     MVGTARSARW PSSVRRRDGR LVPFDLGRIK TAIARAAREV GHRDPGLPAV LAKSVADALA
     GRARGGIPTV EDIQDLVEAQ LAAAGLDDVA RAYVVYRRQH AELRATKELI GVRDELKLSV
     AAVTVLGERY LLRDDHGRPV ESTGEMMDRV ANHVAGAEEK FRPGSSAVWA QRFSALLRGL
     EFLPNSPTLM NAGTELGMLS ACFVLPVDDS LHSIFTTLAQ SADIHQAGGG TGYTFTHLRP
     AGDSVARTGG TASGPLSFLR LFDYAAAVIS MGGRRRGASM AVLDVSHPDI FDFVTTKSGS
     PSELNQFNLS VGVTDEFLRA VGRGGSHRLV NPRTGATVAT VPAADLFTAI CEAAHRCGDP
     GLVFLDTINR ANPTPALGRI EATNPCGEVP LLPYESCNLG SINLARMVNG GGVDWDRLAA
     VAELAVRFLD DVIDVSRFPF PEIEAATQAT RKIGLGVMGL AEMLAGLGIP YDSERGVRLA
     GRIARTVNRV AHAASERLAE ERGAFPAFPD SRFAGSVPRR NAQLTSIAPT GTISLIAGTS
     AGIEPMFAIA YVRAVIGRRL LEVNPCFDRL ARDRGFYHPD LIAEIARCGG VREDPYVPAE
     VRAAFPTAAE ITPDWHLRMQ AAVQRHVDAA VSKTVNLPAE STVDDVRAIY LAAWKAKVKG
     ITVYRYGTRA GQVLSYVGSD QALLAADATF SGGCLGRRCE F
//
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