ID A0A0F5VUJ6_9ACTN Unreviewed; 562 AA.
AC A0A0F5VUJ6;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=3'-5' exonuclease {ECO:0000313|EMBL:KKD05798.1};
GN ORFNames=TN53_22240 {ECO:0000313|EMBL:KKD05798.1};
OS Streptomyces sp. WM6386.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1415558 {ECO:0000313|EMBL:KKD05798.1, ECO:0000313|Proteomes:UP000033641};
RN [1] {ECO:0000313|EMBL:KKD05798.1, ECO:0000313|Proteomes:UP000033641}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM6386 {ECO:0000313|EMBL:KKD05798.1,
RC ECO:0000313|Proteomes:UP000033641};
RA Ju K.-S., Doroghazi J.R., Metcalf W.;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKD05798.1}.
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DR EMBL; JXTE01000036; KKD05798.1; -; Genomic_DNA.
DR RefSeq; WP_046260344.1; NZ_JXTE01000036.1.
DR AlphaFoldDB; A0A0F5VUJ6; -.
DR PATRIC; fig|1415558.3.peg.4531; -.
DR OrthoDB; 4414061at2; -.
DR Proteomes; UP000033641; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd06444; DNA_pol_A; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR PRINTS; PR00868; DNAPOLI.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000313|EMBL:KKD05798.1};
KW Hydrolase {ECO:0000313|EMBL:KKD05798.1};
KW Nuclease {ECO:0000313|EMBL:KKD05798.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000033641}.
FT DOMAIN 311..521
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
FT REGION 432..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 562 AA; 61335 MW; 5BA88E3B926B9841 CRC64;
MTDRWALAPA EDGGVEIAPL GADGLPAGPV RREGDLARAV RGRPEVARWV WRSTAEVYPR
LLAAGVRVER CYDIEDAETL LLGHAGRYGE PRSAAAALAR LRGGPVPPDP PLRSAEPGSQ
SSLFEPQAVH LPLTDLLEVY ADQQRRQDAT AHPDRMRLLI TAESAGMLVA AEMNRAGLPW
SADVHRQVLH EMLGERYAGG GEPRRLAELA DEVSAAFGRR VRPDLPADVV KAFAQAGIKV
NSTRRWELES IDHPAVKPLI EYKKLYRIWV AHGWSWLQDW VREGRFRPEF LCHGTVTGRW
VTNGGGALQI PKVIRRAVVA DPGWRLVVAD ADQMEPRVLA AISRDPGLME VAGRESDLYQ
SVSDRAFSGD RDQAKLAVLG AVYGQTSGDG LKNLAALRRR FPRAVAYVDD AARAGEEGRL
VRTWLGRTCP PAAGAGDAAE EAGIPQEDAP ETPADDGWVP GYASRNARAR GRFARNFVVQ
GSAADWTLLL LAALRQTCAD MAAELVFFQH DEVIVHCPEE ETETVVAAIR ESAELAARLT
FGQTPVRFPF STSVVQCYAD AK
//