ID A0A0F6A6C1_9GAMM Unreviewed; 2670 AA.
AC A0A0F6A6C1;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=LTD domain-containing protein {ECO:0000259|PROSITE:PS51841};
GN ORFNames=N479_24025 {ECO:0000313|EMBL:KKE80979.1};
OS Pseudoalteromonas luteoviolacea S4054.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Pseudoalteromonadaceae; Pseudoalteromonas.
OX NCBI_TaxID=1129367 {ECO:0000313|EMBL:KKE80979.1, ECO:0000313|Proteomes:UP000033434};
RN [1] {ECO:0000313|EMBL:KKE80979.1, ECO:0000313|Proteomes:UP000033434}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S4054 {ECO:0000313|EMBL:KKE80979.1,
RC ECO:0000313|Proteomes:UP000033434};
RX PubMed=25879706; DOI=10.1186/s12864-015-1365-z;
RA Machado H., Sonnenschein E.C., Melchiorsen J., Gram L.;
RT "Genome mining reveals unlocked bioactive potential of marine Gram-negative
RT bacteria.";
RL BMC Genomics 16:158-158(2015).
CC -!- SIMILARITY: Belongs to the EndA/NucM nuclease family.
CC {ECO:0000256|ARBA:ARBA00006429}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKE80979.1}.
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DR EMBL; AUXW01000203; KKE80979.1; -; Genomic_DNA.
DR RefSeq; WP_046358489.1; NZ_AUXW01000203.1.
DR PATRIC; fig|1129367.4.peg.5227; -.
DR Proteomes; UP000033434; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004518; F:nuclease activity; IEA:InterPro.
DR CDD; cd10283; MnuA_DNase1-like; 1.
DR CDD; cd04486; YhcR_OBF_like; 1.
DR Gene3D; 2.60.40.2810; -; 6.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR041690; Cadherin_5.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR007346; Endonuclease-I.
DR InterPro; IPR047971; ExeM-like.
DR InterPro; IPR044925; His-Me_finger_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001322; Lamin_tail_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR NCBIfam; NF041766; choice_anch_U; 1.
DR NCBIfam; NF033681; ExeM_NucH_DNase; 1.
DR NCBIfam; NF012211; tand_rpt_95; 6.
DR PANTHER; PTHR42834; ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09210); 1.
DR PANTHER; PTHR42834:SF1; ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09210); 1.
DR Pfam; PF17963; Big_9; 4.
DR Pfam; PF17892; Cadherin_5; 1.
DR Pfam; PF04231; Endonuclease_1; 1.
DR Pfam; PF05345; He_PIG; 3.
DR Pfam; PF00932; LTD; 2.
DR SUPFAM; SSF49313; Cadherin-like; 4.
DR SUPFAM; SSF141072; CalX-like; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF54060; His-Me finger endonucleases; 1.
DR SUPFAM; SSF49299; PKD domain; 1.
DR PROSITE; PS51841; LTD; 2.
PE 3: Inferred from homology;
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..2670
FT /note="LTD domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002499385"
FT DOMAIN 29..180
FT /note="LTD"
FT /evidence="ECO:0000259|PROSITE:PS51841"
FT DOMAIN 815..935
FT /note="LTD"
FT /evidence="ECO:0000259|PROSITE:PS51841"
FT REGION 458..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..474
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..514
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2670 AA; 283277 MW; 9EF523D1C0FA1D51 CRC64;
MNSNNKHRGK LRYLGRCIAM GLCSSVVMGH ANANVIFTEY VEGSSNNKAL EITNFSNNSI
DLSTVSIALT ANGKKLDEVT PLTLSGTLAA GSSYVLYNNG ASDELKALGD IASTATYFNG
DDALTLMING IIVDSIGQVG TDPGSNWGSG DTSTKDKTLR RKIGIENGDT TIDDAFDPAN
EWVGFAKNTF DGLGCSGVTV CGGSGNIPSE ISGSPKGFVN ATDTYVFTPT VTNLDGDTLV
FAIENKPSWA SFDTTTGKLS GTPTAADMGI YDNIVITVND GTVTNALNSF TIMVRAAGTN
DAPVISGTPN TSVQATRQYA FTPVAIDLEN DDLVFSITNK PSWAAINTLS GQLSGTPAES
DVGDHDNIII SVSDGLHAPV SLPAFSITVT DKPGSNYDYT TYYASAIGKV GTELESALSL
IARQGQQRMT YSQVWDALKY TDEDPNNPSN VLLFYTGKSQ SKDTNGGGTT DWNREHSWPK
SHGFPSESQY GYTDIHHLRP TNVKVNSTRS SKDYDDGGNP VDNAPGNFTD SDSFEPRDAV
KGDTARMMFY MAVRYDGTDG SMPDLELVNN ISASSSPTLG VLCNLMDWHR EDQIDQLELD
RHQRIVEQQG NRNPFVDNPE FAETLFGETC PKLGEVAPVI GGQPELIVGT GREYSFTPTA
SDQNKDDLTF SIVNKPSWAT FDTQTGRLSG TPVTADIAVY EHIEISVTDG KSTVSLPSFN
IEVVDSSSIK NPPTISGTPS TSAVVGIAYG FKPAANDEDN DTLTFSITNK PAWADFNTQN
GELTGTPSSQ DVGVTSNIVI GVTDGNTDVV TLPAFSIQVS EQVETSKVIF TEYIEGSSSN
KAVEITNFTG ATLDLSRVTI TLADNGKPLT TEGLRTQTLS GELKHGESHV IANSSANDDI
KSRQDSTSTI TYFNGDDALV LTVDGQIADV FGQVGTDPGS AWGSGNTSTK DKTLRRKDGI
TSGDTTLDDA FDPSVEWKGF EKNTADGLGC SGVSACGSDG GTTPPQVELG ACNDPATLIS
NIQGNQAASP LVNQTVVIEG VVVAAFQGSG QHGGFFIQEE DRHADTDSAT SEGIFVAETN
TQVTIGEQVR VLGTVVEKYD LTQISTVTES LSCATDVLSQ VTPTEVNLPF AKGFDQESLE
GMWISMAQKL HVTLSHNFTK YGEIYLSQGM RMQPTNKYPK DDPRRLELAD LNSRNVLLVD
DNSTQTNPEA ISYYPSFSAE VPLRSGDLVS NMSGVIHYAY GNYKLIPTNT PQFEQANPRR
TKPFDRKSDQ HIRVASFNVL NYFVDFNGRG ANNEKEFNRQ RSKVIRAILA SDADVVGLME
IENNGYGDNS AIKNLIDGLN ERDDTNDWAF INPQIGQIGT DAVTVGIIYR ANRVIPQGSA
QVITDAPFDE ATRAHRPPML QSFKPMNGGK EIRIVVNHFR SKGGSCGEDM DDAVEGACNG
QRILAAKTVV AALTQANVEA SANTNSPVYA ILGDFNAYAY EAPMLEFYNA NFTNISLEKD
AGDNYSYYFS GVAGSLDHML TASSSMDSIA QSMHWHINAD EAAGLDYNTE GKSEDQQNKW
FSDSPYRSSD HDPVITDFDL TNVVLPNNQA PVANDDTAEA VQGEAITIDV LVNDTDADSD
PLTISAATLV SGEGEVSYSD AQVSFTPNVN FVGEATISYT IIDGNGGTAV ATIHVNVIAR
NLAPVAINDT ANTLEDQSVT VSVLSNDTDE NMASVKVTSA TLNSGLGQVT YSDSAITYSP
AENFNGTAQI TYEIRDEAGL SATAHVAITI APQNDAPTAV NDSTVVSAKS LANINVLTND
TDIDGDTLSI TSAEADVGSV EINGNVLQYQ APALNTGHAT ISYSISDGAE TAQATVKVQI
STSNLAPIAT DDFVQLAEGQ SSATIAVLEN DSDPDGDALS LVAVSTNAGN AIIQDNQIVF
STNDTFNGIA QVRYAISDGF GGRAEAVLEL RQNQPSAPVI TAPADLTVNA TGQLTLVDLG
VATAVDGRGE PISVELLGSN FLPSGANKVY WQACGSNNVC EKVAQIVNVR PMVSLPSPSQ
TVVEGQTTTV PVVLSGEHFS YPLAINFTVS GTASEADFTP VSGQITIESG TQGQISIETV
LDEIEDADET IVITLDTSEL NSSVQQRHEI TIVESNIAPT LTLTVQQQDE VRSIMVTEHG
LITITADVMD QNSADTHTIE WQAQTGLSNE STDSTQFSVN ASALSVGVYQ VSATATDNGG
LSDTQTVIFK VVSAQPTLDA NTDTDGDLIS DAQEGYGDDD ADGIPNYLDP IDAQCNVLPS
SGNNWESGLI EVESGVCMAL GSVSLGSNKN AASLDADEAV QTGLISADEG MENRGGIFDF
VVDLPSGVDS VSIVLPQQAA TPANAQYRKY LPNQGWMTFS AQNGNALHSA LGQQGYCPSM
NDNSWQEGLV EGAWCVKLTL VDGGEYDADG IKNGKIVDPG GVSVTQTDNK APVAVDDTLE
AVLNQSVTLH VLANDTDADS DTLYIVSATA MHGAVSINAD SSLQYQSAPD FIGVDTVEYT
LSDGQGGTST ATVQITVVAQ AQPINQPPVT VNDVAEVFNN DTVTVDVIAN DSDPEGHPLT
LISATADSGE VTFTASTITF KPAPHSEGEV TINYVVADEQ DASASGMLVI TVKEAIMIER
VETRTIRSSS GSMPLFLLLL IVPALLRRRQ
//
