ID A0A0F7FH49_9CREN Unreviewed; 553 AA.
AC A0A0F7FH49;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Radical SAM protein {ECO:0000313|EMBL:AKG38165.1};
GN ORFNames=MA03_01120 {ECO:0000313|EMBL:AKG38165.1};
OS Infirmifilum uzonense.
OC Archaea; Thermoproteota; Thermoprotei; Thermofilales; Thermofilaceae;
OC Infirmifilum.
OX NCBI_TaxID=1550241 {ECO:0000313|EMBL:AKG38165.1, ECO:0000313|Proteomes:UP000067434};
RN [1] {ECO:0000313|EMBL:AKG38165.1, ECO:0000313|Proteomes:UP000067434}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1807-2 {ECO:0000313|EMBL:AKG38165.1,
RC ECO:0000313|Proteomes:UP000067434};
RX PubMed=26664700; DOI=10.1186/s40793-015-0105-y;
RA Toshchakov S.V., Korzhenkov A.A., Samarov N.I., Mazunin I.O., Mozhey O.I.,
RA Shmyr I.S., Derbikova K.S., Taranov E.A., Dominova I.N.,
RA Bonch-Osmolovskaya E.A., Patrushev M.V., Podosokorskaya O.A.,
RA Kublanov I.V.;
RT "Complete genome sequence of and proposal of Thermofilum uzonense sp. nov.
RT a novel hyperthermophilic crenarchaeon and emended description of the genus
RT Thermofilum.";
RL Stand. Genomic Sci. 10:122-122(2015).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CP009961; AKG38165.1; -; Genomic_DNA.
DR RefSeq; WP_052883508.1; NZ_CP009961.1.
DR AlphaFoldDB; A0A0F7FH49; -.
DR STRING; 1550241.MA03_01120; -.
DR GeneID; 25400789; -.
DR KEGG; thf:MA03_01120; -.
DR PATRIC; fig|1550241.5.peg.228; -.
DR HOGENOM; CLU_478700_0_0_2; -.
DR OrthoDB; 2305at2157; -.
DR Proteomes; UP000067434; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd02068; radical_SAM_B12_BD; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR026447; B12_SAM_Ta0216.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR NCBIfam; TIGR04190; B12_SAM_Ta0216; 1.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR PANTHER; PTHR43409:SF1; TIGR04190 FAMILY B12-BINDING DOMAIN_RADICAL SAM DOMAIN PROTEIN; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDF00326; 5''-pyrrole_methytransferase; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000067434}.
FT DOMAIN 29..165
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
SQ SEQUENCE 553 AA; 63906 MW; 5B29E6E04C27AA5A CRC64;
MTRSYDLVLI HPPSVYDFRD LKRVHYGPIS DVIPSKPIFD MYPAGFFYLA SYLEKRGVRV
GLYNVAARMV NEPDLDVPHL LKTIKSSVYG FDIHWLVHSH GAIELARLVK ELHQAPIIIG
GLSATYYWRE IIEKYPFVDV VVLGDTTEPI VFELVQALEK GEMARLQNIP NLAFRQEGKL
KFTGLKYVPV ELDDLKPDYK IISKVMIKSG LKNSLPWSSF LKHPVTAVIT YKGCSLNCLA
CGGSNFTYHV IFRRKMLGVK SPRTLFEEYK EITERLRAPI FFVNDLQLLG RKFIEEFTSL
LAQEKTDIEL FFEFFTPPSR DILNLYRKTG DKVYLQISPE SHDERVRKAY GRPYGNASLK
EFVRNARELG FTRVDMYFMV GLPMQTPLNV QALGDFYLEL FKIGGRSVDA FVAPLAPFVD
PGSIAFHMPR KFGYRILKHT LEEHRELLTA PNWYLMLNYE TEWMTRVQIA EATYNAVESL
TRAKYEAGVI SKDYMEDVLD SIRRIRSGQP RLGLDSKETL REEELYPARK LWITYLTPRS
LAELMLYSIL YSI
//
