ID A0A0F7FUB3_9ACTN Unreviewed; 362 AA.
AC A0A0F7FUB3;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000256|ARBA:ARBA00015325};
DE AltName: Full=Foldase YidC {ECO:0000256|ARBA:ARBA00033342};
DE AltName: Full=Membrane integrase YidC {ECO:0000256|ARBA:ARBA00033245};
DE AltName: Full=Membrane protein YidC {ECO:0000256|ARBA:ARBA00031538};
GN ORFNames=SXIM_26800 {ECO:0000313|EMBL:AKG44064.1};
OS Streptomyces xiamenensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=408015 {ECO:0000313|EMBL:AKG44064.1, ECO:0000313|Proteomes:UP000034034};
RN [1] {ECO:0000313|Proteomes:UP000034034}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MCCC 1A01550 {ECO:0000313|Proteomes:UP000034034};
RA Xu J.;
RT "Complete genome sequence of a mangrove-derived Streptomyces xiamenensis.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. Aids folding of multispanning membrane
CC proteins. {ECO:0000256|ARBA:ARBA00025034}.
CC -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC Specifically interacts with transmembrane segments of nascent integral
CC membrane proteins during membrane integration.
CC {ECO:0000256|ARBA:ARBA00026028}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU003945}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003945}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC {ECO:0000256|ARBA:ARBA00010527}.
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DR EMBL; CP009922; AKG44064.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0F7FUB3; -.
DR STRING; 408015.SXIM_26800; -.
DR KEGG; sxi:SXIM_26800; -.
DR PATRIC; fig|408015.6.peg.2716; -.
DR HOGENOM; CLU_036138_3_1_11; -.
DR Proteomes; UP000034034; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0051205; P:protein insertion into membrane; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd20070; 5TM_YidC_Alb3; 1.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR028055; YidC/Oxa/ALB_C.
DR InterPro; IPR047196; YidC_ALB_C.
DR NCBIfam; TIGR03592; yidC_oxa1_cterm; 1.
DR PANTHER; PTHR12428:SF65; INNER MEMBRANE PROTEIN ALBINO3, CHLOROPLASTIC; 1.
DR PANTHER; PTHR12428; OXA1; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003945};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022927}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 36..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..254
FT /note="Membrane insertase YidC/Oxa/ALB C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02096"
FT REGION 271..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..297
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 362 AA; 40883 MW; 5F24A6487AA12C9F CRC64;
MDTINSILSP LYYAVSWIVI RFHDLYSLVF NEDSGWAWGL SIVSLVVVIR IALIPLFFKQ
IKSTRNMQAL QPKMKKIQER YKNDKQRQSE EMMKLYRETG TNPLSSCLPI LAQSPFFIAL
FQVLNHIANN DKVGVLTQEQ VTSAREATIF GAPIAARFLD SADKLAELGA SLVDVRVVTV
IMIVLMSASQ FFTQRQLMTK NVDLTVKTPF MNQQKMLMYI FPIMFAVFGI NFPVGVLIYW
LTTNVWTLGQ QMYVITRNPT PGSIAFQQRQ ERLKKKGKLK EDPAVAEAKK AAETARGTRT
QPKRQSKSQR QSGGTHPQGK PESGQPAAQQ PEKPERAQPK QQGKQRPKKA QPGKPKSPNS
KK
//
