ID A0A0F7HE06_SERFO Unreviewed; 887 AA.
AC A0A0F7HE06;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00012663};
DE EC=3.2.1.52 {ECO:0000256|ARBA:ARBA00012663};
DE AltName: Full=Beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00030512};
DE AltName: Full=N-acetyl-beta-glucosaminidase {ECO:0000256|ARBA:ARBA00033000};
GN Name=chb {ECO:0000313|EMBL:VEI66424.1};
GN ORFNames=NCTC13193_01636 {ECO:0000313|EMBL:VEI66424.1}, WN53_15620
GN {ECO:0000313|EMBL:AKG70419.1};
OS Serratia fonticola.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Serratia.
OX NCBI_TaxID=47917 {ECO:0000313|EMBL:AKG70419.1, ECO:0000313|Proteomes:UP000034699};
RN [1] {ECO:0000313|EMBL:AKG70419.1, ECO:0000313|Proteomes:UP000034699}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 4576 {ECO:0000313|EMBL:AKG70419.1,
RC ECO:0000313|Proteomes:UP000034699};
RA Chan K.-G., Ee R.;
RT "Complete Genome Sequencing of Serratia Fonticola DSM-4576.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:VEI66424.1, ECO:0000313|Proteomes:UP000270487}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC13193 {ECO:0000313|EMBL:VEI66424.1,
RC ECO:0000313|Proteomes:UP000270487};
RG Pathogen Informatics;
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine
CC residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52;
CC Evidence={ECO:0000256|ARBA:ARBA00001231};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP011254; AKG70419.1; -; Genomic_DNA.
DR EMBL; LR134492; VEI66424.1; -; Genomic_DNA.
DR RefSeq; WP_024483172.1; NZ_SUPV01000004.1.
DR AlphaFoldDB; A0A0F7HE06; -.
DR STRING; 47917.AV650_11080; -.
DR GeneID; 30321602; -.
DR KEGG; sfw:WN53_15620; -.
DR PATRIC; fig|47917.8.peg.3234; -.
DR Proteomes; UP000034699; Chromosome.
DR Proteomes; UP000270487; Chromosome 1.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030247; F:polysaccharide binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd02847; E_set_Chitobiase_C; 1.
DR CDD; cd06569; GH20_Sm-chitobiase-like; 1.
DR Gene3D; 2.60.40.290; -; 1.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR008965; CBM2/CBM3_carb-bd_dom_sf.
DR InterPro; IPR012291; CBM2_carb-bd_dom_sf.
DR InterPro; IPR004866; CHB/HEX_N_dom.
DR InterPro; IPR004867; CHB_C_dom.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR015882; HEX_bac_N.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF21; BETA-HEXOSAMINIDASE A; 1.
DR Pfam; PF03173; CHB_HEX; 1.
DR Pfam; PF03174; CHB_HEX_C; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF02838; Glyco_hydro_20b; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SMART; SM01081; CHB_HEX; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
DR SUPFAM; SSF49384; Carbohydrate-binding domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000313|EMBL:VEI66424.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:VEI66424.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000034699};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..887
FT /note="beta-N-acetylhexosaminidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5033223030"
FT DOMAIN 36..197
FT /note="Chitobiase/beta-hexosaminidases N-terminal"
FT /evidence="ECO:0000259|SMART:SM01081"
FT ACT_SITE 540
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR625705-1"
SQ SEQUENCE 887 AA; 99146 MW; DD62589B48D68F21 CRC64;
MNKFKMSALA ALTATVGLLG SVGSAMANQQ VVDQLSQLQV NLKMLDNRAA ENGVDCAKLG
ADWASCHKVL ITLTNGNQEI KDKDWAIYFH SPRQTLKVDN DQFKITHITG DLYKLEPTDK
FTSFPANQAV EIPIIAEYWQ LFRTDFLPRW YATSGDAQPK ILSNTDTEDV NQFVAPFTGD
QWKRTKDDNN ILMVPESRFT KNQDLKVLPM ASLRGQIIPT PMEVKVHAKD IDLSKGVALE
LSALTKPAAD AAAERFALLG IESQANGYPI KTDIKPAAFK GDQAVPGAYQ LKIGEKGAEI
VGFDQTGVFY GLQSILSLIP SDGSKKIATL DAKDAPRFQY RGIFLDVARN FHQKDAVLRL
LDQMAAYKLN KFHFHLTDDE GWRIEIPGLP ELTEVGGQRC HDLSETTCLM PQYGSGPAPH
GGFFSRQDYI DIVKYAQARQ IEVIPEIDMP AHARAAITSM EARYKKLLAE GKEKEANEFR
LVDPTDTSNT TSVQYFNRQS YLNPCLDSSK NFVDKVIGEV AQMHKEAGQP LKTWHFGGDE
AKNIRLGAGY TDVKNPEAGK GILDLSKEDK PWAKSQVCQA IIKDGKVEDM EHLPSYFGLE
VSQLVKAHGI DRMQAWQDGL KDAKDSKAFA TKHVAVNFWD TLYWGGFDSA NDWANKGYDV
VISNPDYVYM DFPYEVSPDE HGYYWGTRFS DEQKIFSFAP NNLPQNAETS VDRDGNHFTA
KSDKPWPGAY GLSAQLWSEV VRTDQQMEYM IYPRAVSLAE RAWHRASWEQ DYKAGREYKG
GETHQVDTKT LDQDWLRFAN LIGQRELAKM DKAGVSYRLP VPGARIIGGK LEANIALPGL
GIEYSTDGGK QWQRYDDKAR PSVAGDVQIR AISPDGKRFS RAEPVKA
//
