ID A0A0F7IF43_9EURY Unreviewed; 1145 AA.
AC A0A0F7IF43;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=GAH_01023 {ECO:0000313|EMBL:AKG91653.1};
OS Geoglobus ahangari.
OC Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC Geoglobus.
OX NCBI_TaxID=113653 {ECO:0000313|EMBL:AKG91653.1, ECO:0000313|Proteomes:UP000034723};
RN [1] {ECO:0000313|EMBL:AKG91653.1, ECO:0000313|Proteomes:UP000034723}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=234 {ECO:0000313|EMBL:AKG91653.1,
RC ECO:0000313|Proteomes:UP000034723};
RA Manzella M.P., Holmes D.E., Rocheleau J.M., Chung A., Reguera G.,
RA Kashefi K.;
RT "The complete genome sequence of the hyperthermophilic, obligate iron-
RT reducing archaeon Geoglobus ahangari strain 234T.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
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DR EMBL; CP011267; AKG91653.1; -; Genomic_DNA.
DR RefSeq; WP_052747769.1; NZ_CP011267.1.
DR AlphaFoldDB; A0A0F7IF43; -.
DR STRING; 113653.GAH_01023; -.
DR GeneID; 25419500; -.
DR KEGG; gah:GAH_01023; -.
DR HOGENOM; CLU_263797_0_0_2; -.
DR InParanoid; A0A0F7IF43; -.
DR OrthoDB; 45790at2157; -.
DR Proteomes; UP000034723; Chromosome.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR011639; MethylTrfase_TaqI-like_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR025931; TaqI_C.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF07669; Eco57I; 1.
DR Pfam; PF12950; TaqI_C; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:AKG91653.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000034723};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 678..792
FT /note="Type II methyltransferase M.TaqI-like"
FT /evidence="ECO:0000259|Pfam:PF07669"
FT DOMAIN 918..1015
FT /note="TaqI-like C-terminal specificity"
FT /evidence="ECO:0000259|Pfam:PF12950"
SQ SEQUENCE 1145 AA; 134927 MW; A3D07033E3534878 CRC64;
MPSKVEELRK EIEKKLSKFE MDEVTVGEKT YPLYVFDKDE DINLFEGFLY ANVNTKEEFS
LLSNYKPPVS GYAGRIGIII YKDHEIYIKD YRTNKQIRKT ISKLNELFLK KLRKVLEEPK
SENFSALFSR SDVIEEFYVL YKKSKEFLLD NINGISEEAK RKEFVDNFMM QMLTLWYLQE
KGFFNRDKRY FITKFMDLKQ KKLFGGFESY YAFLRHFFKQ ISGYSDEPYV EDESIGKCVV
IGPAVFLNGE DNPVIAIPDK CFYQEGVTEK LVNLTPKGRR RTISEDDIDF DIPLLNLFES
RDWVDGDIDE YVLGSLYEKL MTEDKRKKTG AYYTPEEITS YICKNTIEPY LVDRINEEFG
KDYGSIDELI NAGDKEGLTT LFNLLQNIKI LDPAVGSAHF LESAINVLVD IYRKLRDRAK
EVGIEKLEIL VADEDGKIKP LNLLEIPEKE GLFEVYVKFF IILSRNIYGV DINPSALKVA
RARLFLTLAR HFNVSAGVFI RFPNVHFNLR EGNSLIGYVD VPRGRKETTQ VTLDFNFEDH
EIQYIREMIK VDDELKEYLP AIARSLRIEG DLVREVEEMN RILASKKIKW SEFEKVLKTK
EKIIRVLVAS LNSKYAVKLN NLLREITKLF NRKLDEKFAE EYGIDLDKLK KLKDIPWERK
MFHWVFEFPE VFLEKKGFDV VIGNPPYGRL KQIIEDKKEK DFMSKIYGKL YSYQVGNLNQ
YKLFLERSYF LVSKGGYFSM IFPSSFLGEN DSKELRKLFF EKAMVKKILE FPERARVFEG
ITQAVTILVY KKEIADQDYE FMLRTNIENR DMVATLSDFV NISRDDLKAL TGDEYRIPLF
TNPKIEWEIL KHISKYPPFK GDENNPPIGD VGVGHLDETF DKEFMSDEPG DDLLIKGIHL
DRYFVNLDPN GPKPRWIKNK EEFFRKKPEA KENIKFERII GRNTINKASK PRLRFAILKP
GYVITNNVKF IILKDKNIYK FYLIALLNSK ILNWRFELFS FQNRVNNYEV EALPIPRIPL
EDQKPFIILA KYMLFLKQYY NYFAKDDRHF QYIIDYFDNL IDCLVYELYL GDVVKIPIKP
LVKDKLRDIE LPDNLLEEDK NKIEKTLNEI KEVFNTLEKD KELNENLYLM KLHPWIKQIY
TSLGG
//
