ID A0A0F7KDB9_9PROT Unreviewed; 1766 AA.
AC A0A0F7KDB9;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Amino acid adenylation domain-containing protein {ECO:0000313|EMBL:TYP84678.1};
DE SubName: Full=Thioester reductase {ECO:0000313|EMBL:AKH38485.1};
GN ORFNames=AAW31_12880 {ECO:0000313|EMBL:AKH38485.1}, BCL69_10399
GN {ECO:0000313|EMBL:TYP84678.1};
OS Nitrosomonas communis.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC Nitrosomonadaceae; Nitrosomonas.
OX NCBI_TaxID=44574 {ECO:0000313|EMBL:AKH38485.1, ECO:0000313|Proteomes:UP000034156};
RN [1] {ECO:0000313|Proteomes:UP000034156}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nm2 {ECO:0000313|Proteomes:UP000034156};
RA Kozlowski J.A., Kits K.D., Stein L.Y.;
RT "Draft genome of Nitrosomonas communis strain Nm2.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AKH38485.1, ECO:0000313|Proteomes:UP000034156}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nm2 {ECO:0000313|EMBL:AKH38485.1,
RC ECO:0000313|Proteomes:UP000034156};
RX PubMed=26769932;
RA Kozlowski J.A., Kits K.D., Stein L.Y.;
RT "Genome Sequence of Nitrosomonas communis Strain Nm2, a Mesophilic Ammonia-
RT Oxidizing Bacterium Isolated from Mediterranean Soil.";
RL Genome Announc. 4:0-0(2016).
RN [3] {ECO:0000313|EMBL:TYP84678.1, ECO:0000313|Proteomes:UP000324176}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nm2 {ECO:0000313|EMBL:TYP84678.1,
RC ECO:0000313|Proteomes:UP000324176};
RA Wagner M.;
RT "Active sludge and wastewater microbial communities from Klosterneuburg,
RT Austria.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP011451; AKH38485.1; -; Genomic_DNA.
DR EMBL; VNHT01000039; TYP84678.1; -; Genomic_DNA.
DR RefSeq; WP_046850525.1; NZ_VNHT01000039.1.
DR KEGG; nco:AAW31_12880; -.
DR PATRIC; fig|44574.3.peg.3131; -.
DR OrthoDB; 8612214at2; -.
DR Proteomes; UP000034156; Chromosome.
DR Proteomes; UP000324176; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:InterPro.
DR CDD; cd17649; A_NRPS_PvdJ-like; 1.
DR CDD; cd05931; FAAL; 1.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR040097; FAAL/FAAC.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000034156};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 82..101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 593..668
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1662..1737
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1766 AA; 198172 MW; 34085A964EAC0C41 CRC64;
MNTRLIPSRS YPDNIVMHLQ TLARERPTDI ALIVVSANGD TLIDKQFDYV SLNLYVRAVA
AVLQDRFDQG DRILLLMDND EHYVVGFLAC LYAGMIAVPV FPPESMREQH LTRLLAIATD
AKARCILTTS EIIPLISEAA ITQLADADIL AVDAIMKNNR FGMASAWHER MPEKDEIAFL
QYTSGSTSTP KGVMVSHHNL MINARVFEEG MSIGENDIFV SWLPLYHDMG LIGGLLQPLH
RGIPAILMTP QFFIERPVRW LEVISRYRAT VSGAPNFAFQ LCIERVRSSQ LQGLDLSTWR
VAFSGAEPVR RDTMRAFIER FSALGFPAGT IYPCYGLAEA TLFVTGGVRG EGMIVHEFLP
DKLAQGQAEV ATQGVPIVAC GFPASNHSVK IMQPEKQIPL ADGHVGEIWT DGLSLAQGYW
QRPQETAETF VDHEGARWLR TGDLGFIHAR QLYIMGRLKD LIIIRGQNIY PQDIELVIEE
EVDAVRKGRI AAFSVEGKEG EGIGVAVEVS RNMQKLVSAE ALVAALSEVV SAICHEPLSV
VVLLNPGALP KTSSGKLQRS ACRQGWRERT LDAYAIYEYG HFVLGGSKPL PCLLEDETEL
ALAAIWETVL HRTGLKRGDH FFAIGGNSLS TVQVVAHISD RWHIPFLPRN LFQHPRLQEC
AAEIKRLASL KEVSQEANTC RLMPMRNEHY SLPLSYGQQR LWFLWQLDPD TTAYHVQHAL
RLSGMLDKQA FVASFQALIE RHESLRTLFR ISTEGVVEQV IQSTSSLAIT DVDLLDWDVT
QREEQATAEA QHIILMPFDL TQGPLLRVAL IRVAEYEYIL VIVMHHIIAD GVSMQILLNE
FAAYYQAYIQ GKPAQLAHLP IQYVDYTVWQ QKWLEAGEKE KQLAYWRSYL GESHPVLTLP
TDRVRRPVTS YPAARHSFDL PQAVLVKLRQ FSFDRGATLF MSLMAAFQVL LFRHTGQQII
RIGVPVANRH RIETMSLIGF FVNTQVLQSQ LHGRMPLAEL LDQVREDAIN AQAHQDLPFE
QLVEALHPQR DLRHNPLFQT TLNHLQKDYR SLQQCSGLAV TDYVLPEQAA QLELRLETVE
LPDGNVSASF IYASNLFHPA LIERFTRHYL QILQHLSMQP TIAIGDIDLL DETDKQQLTL
WGGHQQTSFI NHPVHHLIEH QADRCPHMTA VISGDIELSY AELNRRANKL AHRLIDLGVK
PEVRVGVALE RSSVELIIGL VAILKAGGAY IPFDPEYPND RLAYMMEDSR TRLLLTQSYL
SERLPYREGI QILELDTLDL SAVNEINPDI TLHSDHLAYV IYTSGSTGRP KGVAVSHGPL
AMHLSAIKKI YGIQQGDHEL MFFSMNFDAA AEQWMGPLTE GATLVLSSNH HLAGKGFVEL
IERHKIAILH LPPAYLRLLL PQIDRTRQWV RTCIAGGEAW YAADVIAARA IFQKARLVNA
YGPTETVVTP TAWIDQSNEN ALTSVIGEFA PIGQPVGERT LYVLDAELKL VPPGTAGELY
IGGKGLARGY LDRPALTSER FVANPFDQSG GRLYRTGDLV RWRDDRQLEY LGRLDDQIKL
RGFRVELGEI EARLLTLAGI REAAVIAHEG RHGLRLLAYV VLHDNTQLNA SLLKTALTAT
LPDYMIPSQF IFLDMLPLNP NGKLDRKALP SPEQFDTPDY DPPVNLMEKT IAEIWAEALE
MPQVGLHNNF FDLGGHSLLL IKIKQKLEEH LAKQIAMVDL FKYTTVASLA KFLSQGKTGT
ASLSRHQARA QRQRGAFIQR KQERIQ
//
