ID A0A0F7N1G5_9ACTN Unreviewed; 556 AA.
AC A0A0F7N1G5;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=3'-5' exonuclease {ECO:0000313|EMBL:AKH81283.1};
GN ORFNames=AA958_02830 {ECO:0000313|EMBL:AKH81283.1};
OS Streptomyces sp. CNQ-509.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=444103 {ECO:0000313|EMBL:AKH81283.1, ECO:0000313|Proteomes:UP000034283};
RN [1] {ECO:0000313|EMBL:AKH81283.1, ECO:0000313|Proteomes:UP000034283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CNQ-509 {ECO:0000313|EMBL:AKH81283.1,
RC ECO:0000313|Proteomes:UP000034283};
RA Ruckert C., Albersmeier A., Leipoldt F., Winkler A., Zeyhle P.,
RA Kalinowski J., Heide L., Kaysser L.;
RT "Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer
RT of Meroterpenoid Chemistry.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
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DR EMBL; CP011492; AKH81283.1; -; Genomic_DNA.
DR RefSeq; WP_047014646.1; NZ_CP011492.1.
DR AlphaFoldDB; A0A0F7N1G5; -.
DR STRING; 444103.AA958_02830; -.
DR KEGG; strc:AA958_02830; -.
DR PATRIC; fig|444103.5.peg.605; -.
DR OrthoDB; 4414061at2; -.
DR Proteomes; UP000034283; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd06444; DNA_pol_A; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR PRINTS; PR00868; DNAPOLI.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000313|EMBL:AKH81283.1};
KW Hydrolase {ECO:0000313|EMBL:AKH81283.1};
KW Nuclease {ECO:0000313|EMBL:AKH81283.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000034283}.
FT DOMAIN 313..515
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
FT REGION 432..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 556 AA; 59533 MW; 2142F8218518747B CRC64;
MRWAMADGPR GGVIVCPVDA AGDPQGPEHT YPHPAHALRH HPTADRWIWS STAAFYPRLL
DAGETVPRCH DVEAAEAILL GHEGMWGLPR SLAAAWARLR GLPVPKDPPP RSFAGEPQPT
LFDAAPARPH GTDDLPALLA VHAAQQDRVA ASAHPHRLRL LLAAESAGML VAAEMHHAGL
PWRADVHDAL LTELLGGRYP GGLEPPRLAA LADDVSRAFG ERVRPDLPAE VVRAFRKAGV
RITSTRKWEL QDIDHPAVAP LLEYKKLYRL HTAHGWSWLQ TWVHGGRFRP EYLPGGAMSG
RWTTHGGGAL QIPRVVRRAV VADEGWRLVV ADADQMEPRV LAAVSGDAGL MAAADGTRDL
YEALAARAFA GGRAEAKLAL LGAIYGQTSG DALTYLADLR RRFPAAVAYV DEAARAGEEG
RLVRSHLGRT CAPSEAADDG EAGLPQEDDG GGAAARGGAA ARARGRFTRN FVVQASAAEW
ALCLLAALRQ ELAGMRAELV FFQHDEVIVH CPEAEAPAVE KALAVASARA GEVMFGQTPV
VFSFTTAVVE CYADAR
//
