ID A0A0F7N228_9ACTN Unreviewed; 1661 AA.
AC A0A0F7N228;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:AKH80922.1};
GN ORFNames=AA958_00665 {ECO:0000313|EMBL:AKH80922.1};
OS Streptomyces sp. CNQ-509.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=444103 {ECO:0000313|EMBL:AKH80922.1, ECO:0000313|Proteomes:UP000034283};
RN [1] {ECO:0000313|EMBL:AKH80922.1, ECO:0000313|Proteomes:UP000034283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CNQ-509 {ECO:0000313|EMBL:AKH80922.1,
RC ECO:0000313|Proteomes:UP000034283};
RA Ruckert C., Albersmeier A., Leipoldt F., Winkler A., Zeyhle P.,
RA Kalinowski J., Heide L., Kaysser L.;
RT "Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer
RT of Meroterpenoid Chemistry.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP011492; AKH80922.1; -; Genomic_DNA.
DR RefSeq; WP_047014288.1; NZ_CP011492.1.
DR STRING; 444103.AA958_00665; -.
DR KEGG; strc:AA958_00665; -.
DR PATRIC; fig|444103.5.peg.153; -.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000034283; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR CDD; cd08952; KR_1_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR041618; PKS_DE.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR015083; Polyketide_synth_docking.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF08990; Docking; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF18369; PKS_DE; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000034283};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 35..461
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1492..1567
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1616..1661
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1661 AA; 173255 MW; A0ECC288D39F956D CRC64;
MASSNEEKLR DYLKAVTADL RQTRQRLQSL EERDHEPIAV VGMACRYPGG AVSPDALWEL
VSAGGDAIGE FPADRGWDLE AVFDADPDKA GTSYARRGGF LYDLPEFDAG LFGVSPREAA
AMDPQQRLLL ELAWEALERA GIAADGLRGS ATGVFAGTSA ADYGPRLHEA TAGAEGYMLT
GTTPSVASGR IAYTLGLEGP ALTVDTACSS SLVAVHLATR ALRARECTMA LAGGATVMST
PGMFVEFSRQ RGLASDGRCK SFSDDADGTG WSEGAGMLVL ERLSDARAAG HPVLAVIRGS
AVNQDGASNG LTAPNGPAQQ RVIAQALADA RLTARQVDAV EAHGTGTSLG DPIEAQALLA
TYGREHSAEQ PLWLGSVKSN IGHTQTAAGV AGIIKMVQAM RHGRLPRTLH SETPSRHVEW
AGGGVALLAE EVDWPESDRP RRAAVSAFGI SGTNAHVILE EGPPPAEPAE RSGEGGPRTA
LWTLSARTGE ALRARAAELA EAVRTEEPPA AGDVGWSLAT TRAAFDERAV VLGGDTAELA
EGLAALAADR GSPRVVRGSA VSGAARPVFV FSGQGAQWPG MAVGLWDSEP VFAASMERCA
AALAPYTGYT LREKLTAPAD DAAWERDDVV QPLMWAVMVS LAELWRHHGV TPAAVVGHSQ
GEFAAAVAAG ALSLEDGARL VAVRSRVVHA LSGHGSMASV SLPVAEVEKR LAETGGDVGV
AAVNGPSATV VAGVDADVRA FMRDCEEQGV RTRTVPIAYA SHSPLVEPVR EEMLRELAAI
TPRAGEVPFY STVTGEPMPT ESLDAAYWYR NLRSPVLFAQ TVERLMDAGH TVFLEMGPHP
VLVPAIEQVL DATETDGRAL GTLRRDEDGE PRFKQALAEA YAAGVVPDWQ VLFPDARTVP
LPTYPFQRRR YWLADRDDRA PRAAQTRAGG SDEAFWALVE QADTEALRRE LPEVGEDALR
AVVPALHRWR SRTRTDAALA GQRYEIGWRP AAERRTPGPD GHWLLVTRTG AAGRLADWAD
AAGAALSARG AGVTVVELDE RADDERAGIA RRLSAALAGE AVDGVLSLLP LDERPHPGHA
ALPSGVGGLL GLVQALAGLG VAAPVWSLTC AAVKALDDDV LAHPEQAETW GLGRVVALEQ
PQLWGGLVDL PERPGDEDWL RLCAVLAGGA GDEDQVAIRP GGPRVRRLLP APAPADSPVW
QPGGTVVVTG GSGSLAPHLA RWLADGGAEH IVLASRRGPD APGHEALAAE LAGRGVGVTA
LSCDLTDRDS VRALLRRAAE LGGPVRAVVH AATSTRLEPL ADATAAGVAE VLAAKALGAV
HLAESMDPDG PAELVFFSSI AAVWGSGEHG AYAAANAFLD AYAQQLRGRG RKVTSVAFGA
WRSEVLPEGL DEAQLERQGL PLLDPELALA GLGREVAGAG GGRPVTLVDV DWETFAPVFA
SARPRPLLDE IPAVRGALRR SAEAGGTGAA DGGDTGERLR KLAGLPEAAR GREVLDVVTA
EVAAVLGHSP ADRPAPMRTF KELGFDSLTA VALRNRLRAA TGLSLPVTLV FDHPSPQALA
RFLTGQLGTA GEQAAPGSVH EELDRLAAAL DAAPVEGAER AAVRDRLQAL AAALAGGGTA
ASGRGEDDDA DLDDASTDDL LKIIDDEFGP AEPGPTASTT G
//