ID A0A0F7N308_9ACTN Unreviewed; 688 AA.
AC A0A0F7N308;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Membrane protein {ECO:0000313|EMBL:AKH82381.1};
GN ORFNames=AA958_09235 {ECO:0000313|EMBL:AKH82381.1};
OS Streptomyces sp. CNQ-509.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=444103 {ECO:0000313|EMBL:AKH82381.1, ECO:0000313|Proteomes:UP000034283};
RN [1] {ECO:0000313|EMBL:AKH82381.1, ECO:0000313|Proteomes:UP000034283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CNQ-509 {ECO:0000313|EMBL:AKH82381.1,
RC ECO:0000313|Proteomes:UP000034283};
RA Ruckert C., Albersmeier A., Leipoldt F., Winkler A., Zeyhle P.,
RA Kalinowski J., Heide L., Kaysser L.;
RT "Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer
RT of Meroterpenoid Chemistry.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR EMBL; CP011492; AKH82381.1; -; Genomic_DNA.
DR RefSeq; WP_047015727.1; NZ_CP011492.1.
DR AlphaFoldDB; A0A0F7N308; -.
DR STRING; 444103.AA958_09235; -.
DR KEGG; strc:AA958_09235; -.
DR PATRIC; fig|444103.5.peg.1948; -.
DR OrthoDB; 2365435at2; -.
DR Proteomes; UP000034283; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000034283};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 161..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 185..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 218..240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 261..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 350..370
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 496..513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 520..541
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 553..574
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 594..617
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 623..646
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 193..315
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 663..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 688 AA; 71182 MW; FB77BF0A8F793BFA CRC64;
MLGLWVAILA LAMPFGSKLG DVSRDRAVDY LPGSADSTQV SQIAEEMPGG DTLAGILVYQ
RDGGITAADR ELAAGHAGAV ADRFELAKDG TPQAVPAEDG STLMLPFSVV GLPDEDAQTA
AVEEIREEIV ADPPEGLSVE LGGPAGIQAD AEAVYEEVDG TLMYATAGIV TILLILTYRS
PFLWLLPLVC VGVASMSAMA LVYGLVQAFD LTVNSMSSAV MTVLIFGAGT DYALLLVARY
REELRRTTDA QEAMLTAVRN CGPAILASSG TVAAGLICLL AADLNSSAGL GPVGAVGVVC
ALAVMTTLLP ALMVLFGRRI FWPLVPAYGS EPKRRGFFDR MGSSVGRRPA AILLGGVVLL
GALALGAFNL PGNLKQEDAF TDKPESITAM EKLKDAYPEQ SAQAIVVVAD AARADAALSA
AQGVEGVVSA ETARSGNGYT EITVYAADPP QSAGEDRTIA DLRSELGALD GADALVGGPS
AEALDLAEAN SGDRKLVIPL TLAAVLVILI VLLRSLVAPL VLTVAVVASW GAAMGIGGLI
FEPVMGYPGI GGELALLTFV FGVALGVDYG IFLLHRMREE ATNGADTRTA ALTALRRTGG
VIASAGLVLA ATFAALATMP MVMMFELGFV VAVGVLLDTF LVRTYLVTSA SWLLGKKIWW
PGPLSKREEA PPSAPGEQRE PEPAGAAR
//
