ID A0A0F7N3M4_9ACTN Unreviewed; 423 AA.
AC A0A0F7N3M4;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Methyltransferase {ECO:0000313|EMBL:AKH81402.1};
GN ORFNames=AA958_03500 {ECO:0000313|EMBL:AKH81402.1};
OS Streptomyces sp. CNQ-509.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=444103 {ECO:0000313|EMBL:AKH81402.1, ECO:0000313|Proteomes:UP000034283};
RN [1] {ECO:0000313|EMBL:AKH81402.1, ECO:0000313|Proteomes:UP000034283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CNQ-509 {ECO:0000313|EMBL:AKH81402.1,
RC ECO:0000313|Proteomes:UP000034283};
RA Ruckert C., Albersmeier A., Leipoldt F., Winkler A., Zeyhle P.,
RA Kalinowski J., Heide L., Kaysser L.;
RT "Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer
RT of Meroterpenoid Chemistry.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP011492; AKH81402.1; -; Genomic_DNA.
DR RefSeq; WP_047014760.1; NZ_CP011492.1.
DR AlphaFoldDB; A0A0F7N3M4; -.
DR STRING; 444103.AA958_03500; -.
DR KEGG; strc:AA958_03500; -.
DR PATRIC; fig|444103.5.peg.739; -.
DR OrthoDB; 4327941at2; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000034283; Chromosome.
DR GO; GO:0008276; F:protein methyltransferase activity; IEA:InterPro.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd11644; Precorrin-6Y-MT; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR012818; CbiE.
DR InterPro; IPR006365; Cbl_synth_CobL.
DR InterPro; IPR013216; Methyltransf_11.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR02467; CbiE; 1.
DR PANTHER; PTHR43182; COBALT-PRECORRIN-6B C(15)-METHYLTRANSFERASE (DECARBOXYLATING); 1.
DR PANTHER; PTHR43182:SF1; COBALT-PRECORRIN-7 C(5)-METHYLTRANSFERASE; 1.
DR Pfam; PF08241; Methyltransf_11; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR PIRSF; PIRSF036428; CobL; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE 3: Inferred from homology;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:AKH81402.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000034283};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AKH81402.1}.
FT DOMAIN 15..182
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 274..324
FT /note="Methyltransferase type 11"
FT /evidence="ECO:0000259|Pfam:PF08241"
SQ SEQUENCE 423 AA; 42924 MW; C8CD205BF892E92D CRC64;
MADRVTVIGW DGSPLTEAAL GALGAASLVA GAAHHLALPE VPPGAERIRL GSVGLAARRI
ARHRGTAVVI ADGDPGFFGV VRTLRAPEHG LEVEVLPAVS SVAAAFARAG MPWDDAQVVV
AHERNLRRAV NVCRAHPKVA VLTSPGAGPA ELALLLRDVH RTFVICEELG GAHERVTVLT
SDKVAEHVWR DPNVTLVIGG GIGAGAGPTT AGGAAAPAAG GWLAGHDAGY PPPVRGWSLA
PAEYGAAPDE GEAPQLRAVQ LARLGPRQGD LVWDIGAGSG AAAVEAARFG AAVIAVDRDP
GACARASAAA RRFGVLLQTV HGTAPGVLND LPEPDVVRVG GGGAAAVAGC AARRPERIVA
HARTRDGAEE IVRALTDAGY AVECSLLQSV DLDPQGPADA GAGAGWRERE RTVVFLIAGS
RAG
//
