ID A0A0F7RQF3_PANTR Unreviewed; 130 AA.
AC A0A0F7RQF3; A0A2J8PIB1;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Glycoprotein hormone subunit beta 5 {ECO:0000313|Ensembl:ENSPTRP00000078124.1};
DE SubName: Full=Glycoprotein-beta 5 {ECO:0000313|EMBL:CCP37880.1};
GN Name=GPHB5 {ECO:0000313|Ensembl:ENSPTRP00000078124.1,
GN ECO:0000313|VGNC:VGNC:58546};
GN Synonyms=GPB5 {ECO:0000313|EMBL:CCP37880.1};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:CCP37880.1};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000078124.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:CCP37880.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25941635; DOI=10.1016/j.mgene.2015.02.005;
RA Premzl M.;
RT "Initial description of primate-specific cystine-knot Prometheus genes and
RT differential gene expansions of D-dopachrome tautomerase genes.";
RL Meta Gene 4:118-128(2015).
RN [3] {ECO:0000313|EMBL:CCP37880.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26862561; DOI=10.1016/j.dib.2015.11.056;
RA Premzl M.;
RT "Curated eutherian third party data gene data sets.";
RL Data Brief 6:208-213(2016).
RN [4] {ECO:0000313|EMBL:CCP37880.1}
RP NUCLEOTIDE SEQUENCE.
RX DOI=10.1016/j.genrep.2019.100414;
RA Premzl M.;
RT "Eutherian third-party data gene collections.";
RL Gene Rep 16:100414-100414(2019).
RN [5] {ECO:0000313|Ensembl:ENSPTRP00000078124.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC {ECO:0000256|ARBA:ARBA00006552}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AACZ04008491; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; HF564675; CCP37880.1; -; Genomic_DNA.
DR RefSeq; XP_016781681.1; XM_016926192.1.
DR STRING; 9598.ENSPTRP00000078124; -.
DR Ensembl; ENSPTRT00000087769.1; ENSPTRP00000078124.1; ENSPTRG00000046283.1.
DR GeneID; 467477; -.
DR KEGG; ptr:467477; -.
DR CTD; 122876; -.
DR VGNC; VGNC:58546; GPHB5.
DR GeneTree; ENSGT00730000111179; -.
DR OMA; MAVRCDC; -.
DR OrthoDB; 2945053at2759; -.
DR Proteomes; UP000002277; Chromosome 14.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0031531; F:thyrotropin-releasing hormone receptor binding; IEA:Ensembl.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0002155; P:regulation of thyroid hormone mediated signaling pathway; IBA:GO_Central.
DR CDD; cd00069; GHB_like; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR001545; Gonadotropin_bsu.
DR PANTHER; PTHR11515; GLYCOPROTEIN HORMONE BETA CHAIN; 1.
DR PANTHER; PTHR11515:SF14; GLYCOPROTEIN HORMONE BETA-5; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR SMART; SM00068; GHB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..130
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015038930"
FT DOMAIN 35..128
FT /note="Glycoprotein hormone subunit beta"
FT /evidence="ECO:0000259|Pfam:PF00007"
SQ SEQUENCE 130 AA; 14232 MW; 2C6C3BC0AA6725B9 CRC64;
MKLAFLFLGP MALLLLAGYG CVLGASSGNL RTFVGCAVRE FTFLAKKPGC RGLRITTDAC
WGRCETWEKP ILEPPYIEAH HRVCTYNETK QVTVKLPNCA PGVDPFYTYP VAIRCDCGAC
STATTECETI
//
