ID A0A0F7ZKK8_9HYPO Unreviewed; 1328 AA.
AC A0A0F7ZKK8;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Reverse transcriptase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=HIM_05267 {ECO:0000313|EMBL:KJZ75341.1};
OS Hirsutella minnesotensis 3608.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Hirsutella.
OX NCBI_TaxID=1043627 {ECO:0000313|EMBL:KJZ75341.1, ECO:0000313|Proteomes:UP000054481};
RN [1] {ECO:0000313|EMBL:KJZ75341.1, ECO:0000313|Proteomes:UP000054481}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3608 {ECO:0000313|EMBL:KJZ75341.1,
RC ECO:0000313|Proteomes:UP000054481};
RX PubMed=25359922; DOI=10.1093/gbe/evu241;
RA Lai Y., Liu K., Zhang X., Zhang X., Li K., Wang N., Shu C., Wu Y., Wang C.,
RA Bushley K.E., Xiang M., Liu X.;
RT "Comparative genomics and transcriptomics analyses reveal divergent
RT lifestyle features of nematode endoparasitic fungus Hirsutella
RT minnesotensis.";
RL Genome Biol. Evol. 6:3077-3093(2014).
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC {ECO:0000256|ARBA:ARBA00008066}.
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DR EMBL; KQ030518; KJZ75341.1; -; Genomic_DNA.
DR OrthoDB; 2695555at2759; -.
DR Proteomes; UP000054481; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR CDD; cd09276; Rnase_HI_RT_non_LTR; 1.
DR CDD; cd01650; RT_nLTR_like; 1.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR013057; AA_transpt_TM.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR33481; REVERSE TRANSCRIPTASE; 1.
DR PANTHER; PTHR33481:SF1; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01490; Aa_trans; 1.
DR Pfam; PF00075; RNase_H; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000054481};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 97..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 125..147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 284..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 321..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 403..427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 433..453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 474..496
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 555..825
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 1045..1178
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1328 AA; 147734 MW; B35BFFAA54981D98 CRC64;
MAHVERPTSS SSPGLSTSSV TPHELERDGC KMSSKRSFVF GGKSFVIGPR IAPLPERLRN
DSIYKGDDSG AAILEKQLAS EAGQDIQYRT CSWQKMAALL FSEYISLAVM SFPQAYSYVG
LVPGLILTII IAGIALYTSL VLWEFCLRHP EVRDVCDLGQ MLFGGKKWAW CATMVMFILN
NTFVQGLHVL VGAEYINTMT EGNQIGGCRT VQFAIVVMVL CWMISLPRTF EVLSKLGTIS
AFFTIIGVIL ATVFAGIQPW PARYDPKTKG EPIVTMLPSP NTTFAQGLGA ALAISFTLFG
QIMLPSFIAE MRDPREFPKS LWACTIVEVV LFSIVGAVIY AYTGNQYVTS PAFGSLQDVY
KKASFSLMVP TILFLGSLYA SVTTRFIFFR VFRDTKHLVG HTLVGWLTWG AILLSTWITA
FIIAQVIPFF SSLLSVMSAL FNSWFGLIFW GVAFFRMRRV DRDVGRCYRP ISDYALSAIN
ILIILTGVLF LTAGTYSSVE SIKDDFRVGN IRGLPCSHLG GQTSRFLPGA DNITVKLLQA
VWDIVRGHVR RLYQGCLTVG HHPGAFREAE VVMIPKPGKK NLSTPRAWRP ISLLSCLGKG
LERLIARRLA WASIHYAVLH PQQAGALPKR SAVDLVAALI HDIEEAFARG QVATLVTADI
QGAFDTAMCN RLVLRLREQG WPDNLARWTG SFMSGRSARV RYQDITTPTT PLQCGLPQGS
PVSPILFLLY TEPIYRLGNP EGRFGYADDT AILCVGQSLE QTSQKASEYL QELVNWGAAN
GISFDPEKTE VMHFSPRRRE TKPPVRHADV EKQPETAMRW LGLWLDRKLT FKTHVEKWTA
KAQTVANHIR SLGNTRRGAL PRAMQRAVRA CVEPILLFGV EAWYPGPTSP SWRQPTVQGP
SRIQQLLRKM SKALVQAVRA ILPTWKTTRI AVLHRESGIP PVRQLLEGRR IRFSARIKSL
DHAHPLAKRT IEIAPRPIIK CVKLKYQLPP KAFPTRLRRT NKLLANCQRP VLVPRKYNNE
TLQPLQNASK EDSANDFLDW LRSIPPSTLI VYSDGSLSPS GAAGYGFTVH QNGHSNRQGA
GRLGPAEVFD AEAKGALEGL KAALRLPSSA RQRIVVCLDN IAAAKCLRGK PSDSSQRVFR
TFQALARTHG KTEVRWIPGH TEIPGNEQAD ILAKTGCAQP EPADAVPTLA FLRKTARQRS
RIAVQAWWDA SAPDKYQSLT LKFPSGCPPE LGLPRTMLHH LLAARTHHGD FADYHERFQH
DDACITCSCG RRKAPTHLFY CRKIQPRCRM RLAPSPTEAI NRAIGRDFDK FVKLAKASSF
FEKICPHH
//
