ID A0A0F7ZPM6_9HYPO Unreviewed; 734 AA.
AC A0A0F7ZPM6;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=HIM_04922 {ECO:0000313|EMBL:KJZ75765.1};
OS Hirsutella minnesotensis 3608.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Hirsutella.
OX NCBI_TaxID=1043627 {ECO:0000313|EMBL:KJZ75765.1, ECO:0000313|Proteomes:UP000054481};
RN [1] {ECO:0000313|EMBL:KJZ75765.1, ECO:0000313|Proteomes:UP000054481}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3608 {ECO:0000313|EMBL:KJZ75765.1,
RC ECO:0000313|Proteomes:UP000054481};
RX PubMed=25359922; DOI=10.1093/gbe/evu241;
RA Lai Y., Liu K., Zhang X., Zhang X., Li K., Wang N., Shu C., Wu Y., Wang C.,
RA Bushley K.E., Xiang M., Liu X.;
RT "Comparative genomics and transcriptomics analyses reveal divergent
RT lifestyle features of nematode endoparasitic fungus Hirsutella
RT minnesotensis.";
RL Genome Biol. Evol. 6:3077-3093(2014).
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DR EMBL; KQ030515; KJZ75765.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0F7ZPM6; -.
DR OrthoDB; 5482027at2759; -.
DR Proteomes; UP000054481; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd07652; F-BAR_Rgd1; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23176:SF138; RHO GTPASE ACTIVATOR; 1.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW Reference proteome {ECO:0000313|Proteomes:UP000054481};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 74..350
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 539..731
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 393..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 734 AA; 80065 MW; 578ADD93ECB89BA4 CRC64;
MVDRRDSGGE GVVAPPPQPP RPQRQRTGSQ SAAEVIAKPQ HEADANGEEP PSPKTSADGI
NDAHRSSIDS ALAKQVEQVT ASELGIPTLL NRLKQSIASA KEFAAFLRRR STLEDEHAQG
LKKLCRANQD MTRRPEHRQG SFAKSYDEMI FIHDRMAENG AQFAASLQQM HEDLAELAAT
AERGRKSWKA AGMAAEQKVV DLEQAMRKSK AKYDSLADEY DRARTGESRQ SGKMLGAFKA
HRSAAQQEED LLKKVQAADQ VYQSHVTTLV TEKSHLLTVA RPEAVKALQD IITETDAATT
MLMQKFAASN EKLLLGDGLI VSPQTGLPGS TSTQARSLRD AVAAIDNKRD LDEYLAAHFS
KIQPKAEIKY ERNPILNPPQ QQHQQATAFK ATPLNMHPPQ STGQTPSTQG TFSPPGPGAL
SRSSTGNLQQ SNQSPAPQNP PAERPKEFPN PHGRSMSHGN PLGQNAPWQG NGSTAEPKGP
PKLSELSFQD SQQLPSQRPA SPPRAPQEAP NSGARAAPAA PPAYGASGQG ANTKPIFGIP
LNRLYERDGL AVPMVVYQCI QAVDLYGLGV EGIYRQSGSL NHINKLKGMF DADSSNPALD
FRNPESFYHD VNSVTGLLKQ FFRDLPDPIL TMEHHDAFIA AAKKEDDVIR RDSLHAIINA
LPDPNYATLR ALTLHLYRVM ENSHVNRMNS HNLAVIFGPT LMGSDPSTAI TDAGWQIKVI
DTILQNTYQI FDED
//
