ID A0A0F7ZVX7_9HYPO Unreviewed; 808 AA.
AC A0A0F7ZVX7;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=EKC/KEOPS complex subunit BUD32 {ECO:0000256|ARBA:ARBA00019973};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
DE AltName: Full=Atypical Serine/threonine protein kinase BUD32 {ECO:0000256|ARBA:ARBA00030980, ECO:0000256|ARBA:ARBA00033194};
DE AltName: Full=EKC/KEOPS complex subunit bud32 {ECO:0000256|ARBA:ARBA00013948};
GN ORFNames=HIM_12619 {ECO:0000313|EMBL:KJZ67992.1};
OS Hirsutella minnesotensis 3608.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Hirsutella.
OX NCBI_TaxID=1043627 {ECO:0000313|EMBL:KJZ67992.1, ECO:0000313|Proteomes:UP000054481};
RN [1] {ECO:0000313|EMBL:KJZ67992.1, ECO:0000313|Proteomes:UP000054481}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3608 {ECO:0000313|EMBL:KJZ67992.1,
RC ECO:0000313|Proteomes:UP000054481};
RX PubMed=25359922; DOI=10.1093/gbe/evu241;
RA Lai Y., Liu K., Zhang X., Zhang X., Li K., Wang N., Shu C., Wu Y., Wang C.,
RA Bushley K.E., Xiang M., Liu X.;
RT "Comparative genomics and transcriptomics analyses reveal divergent
RT lifestyle features of nematode endoparasitic fungus Hirsutella
RT minnesotensis.";
RL Genome Biol. Evol. 6:3077-3093(2014).
CC -!- FUNCTION: Component of the EKC/KEOPS complex that is required for the
CC formation of a threonylcarbamoyl group on adenosine at position 37
CC (t(6)A37) in tRNAs that read codons beginning with adenine. The complex
CC is probably involved in the transfer of the threonylcarbamoyl moiety of
CC threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase
CC activity in the context of the EKC/KEOPS complex and likely plays a
CC supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex
CC also promotes both telomere uncapping and telomere elongation. The
CC complex is required for efficient recruitment of transcriptional
CC coactivators. {ECO:0000256|ARBA:ARBA00003747}.
CC -!- SUBUNIT: Component of the EKC/KEOPS complex composed of at least BUD32,
CC CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
CC {ECO:0000256|ARBA:ARBA00011534}.
CC -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC {ECO:0000256|ARBA:ARBA00004574}.
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DR EMBL; KQ031108; KJZ67992.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0F7ZVX7; -.
DR OrthoDB; 1789758at2759; -.
DR Proteomes; UP000054481; Unassembled WGS sequence.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR040976; Pkinase_fungal.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR PANTHER; PTHR38248:SF2; FUNK1 11; 1.
DR PANTHER; PTHR38248; FUNK1 6; 1.
DR Pfam; PF17667; Pkinase_fungal; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000054481};
KW Telomere {ECO:0000256|ARBA:ARBA00022895}.
FT DOMAIN 449..808
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 528..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 808 AA; 92059 MW; B43B5EC4F39467BB CRC64;
MATLSEHDRD IIARHPLAGS LDHLFQSLRD AVQFYGPAAS AHGGHTGSSK QDHQRSVSRL
LTALMGHETA LDLHSSLSNR NVASELATIL GRLRKDHIDY GHFIPLVKLV AQKASDYEIW
NAVLDLISTL TRVTPPASIP ATFDSTPITH SSASQQGAEQ TRELVERKVF EEIRFCTYRD
VEGFFEKYFD RKEWTRRALD VYEATKDRHV DGAWSDFPDP PVQAGVLDWW FRFQDDFLSE
ERRRYYSTTN PKDLVGGEAQ RQIDLFVKRK NGQPDAAHDW RDVQVVGELK ASNNNKKATL
LQIGRYVRDV FSCQPTRRYV HAFTICGREM EVWVFDRSGC YSPGAFNIHE NPERFVQVIA
GYTMMSDEEL GLDTFTEQDD DGPSIHIEQD EASGKKRLRL ESQAFTRQRA IVCRGTSCYR
TKPLESEDWS YVAKFSWTSD RRKPEADLLR LARQRGVEGI ARLIGHRRIT SINELRSDLT
FAKPYSFRGL SSAASSFSQC FSQPQPLNAL SRSYSELHGL SIADRPLRKR KSVDVGRKPS
KRSRSNSQKS SKGQNEVTYD VEEAQGTSLL APNNGPYDNR VFRCLVISPA GRAIHKYERT
SELLGALRDA IKAHRSLYLK GNILHRDISE NNIIITDRKS TGHMGMLIDL DLAKELGSGR
SGARCRTGTM EFMAIEVLQG ISHTYRHDLE SFFYVFLWLC GRRGWEFLRN QKEQLTPSLM
TKWYTGSYRE IASAKRGHMH VDGFEDILEE FPQPKFDCVK PLCRELRGIL FPYRDGLFIG
TPKDPEILYG PIIKAFDKAI DDVKAMEG
//
