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Database: UniProt
Entry: A0A0F8B0B6_LARCR
LinkDB: A0A0F8B0B6_LARCR
Original site: A0A0F8B0B6_LARCR 
ID   A0A0F8B0B6_LARCR        Unreviewed;       849 AA.
AC   A0A0F8B0B6;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   08-MAY-2019, entry version 28.
DE   SubName: Full=Guanine nucleotide exchange factor VAV2 {ECO:0000313|EMBL:KKF18736.1};
GN   ORFNames=EH28_11731 {ECO:0000313|EMBL:KKF18736.1};
OS   Larimichthys crocea (Large yellow croaker) (Pseudosciaena crocea).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Sciaenidae; Larimichthys.
OX   NCBI_TaxID=215358 {ECO:0000313|EMBL:KKF18736.1};
RN   [1] {ECO:0000313|EMBL:KKF18736.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SSNF {ECO:0000313|EMBL:KKF18736.1};
RC   TISSUE=Blood {ECO:0000313|EMBL:KKF18736.1};
RX   PubMed=25835551;
RA   Ao J., Mu Y., Xiang L.X., Fan D., Feng M., Zhang S., Shi Q., Zhu L.Y.,
RA   Li T., Ding Y., Nie L., Li Q., Dong W.R., Jiang L., Sun B., Zhang X.,
RA   Li M., Zhang H.Q., Xie S., Zhu Y., Jiang X., Wang X., Mu P., Chen W.,
RA   Yue Z., Wang Z., Wang J., Shao J.Z., Chen X.;
RT   "Genome Sequencing of the Perciform Fish Larimichthys crocea Provides
RT   Insights into Molecular and Genetic Mechanisms of Stress Adaptation.";
RL   PLoS Genet. 11:E1005118-E1005118(2015).
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DR   EMBL; KQ042128; KKF18736.1; -; Genomic_DNA.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR   CDD; cd00029; C1; 1.
DR   CDD; cd00014; CH; 1.
DR   CDD; cd01223; PH_Vav; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd10406; SH2_Vav2; 1.
DR   CDD; cd11977; SH3_VAV2_2; 1.
DR   Gene3D; 1.10.418.10; -; 2.
DR   Gene3D; 1.20.900.10; -; 2.
DR   Gene3D; 2.30.29.30; -; 1.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR022613; CAMSAP_CH.
DR   InterPro; IPR001715; CH-domain.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR037832; PH_Vav.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR035880; VAV2_SH2.
DR   InterPro; IPR035732; VAV2_SH3_2.
DR   Pfam; PF00130; C1_1; 1.
DR   Pfam; PF11971; CAMSAP_CH; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 2.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF07653; SH3_2; 2.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00109; C1; 1.
DR   SMART; SM00033; CH; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00326; SH3; 2.
DR   SUPFAM; SSF47576; SSF47576; 2.
DR   SUPFAM; SSF48065; SSF48065; 2.
DR   SUPFAM; SSF50044; SSF50044; 2.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50021; CH; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50002; SH3; 2.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Guanine-nucleotide releasing factor {ECO:0000256|SAAS:SAAS01163629};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00253054};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW   SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192,
KW   ECO:0000256|SAAS:SAAS01042643}; Zinc {ECO:0000256|SAAS:SAAS00253075}.
FT   DOMAIN        1    120       Calponin-homology (CH).
FT                                {ECO:0000259|PROSITE:PS50021}.
FT   DOMAIN      149    363       DH. {ECO:0000259|PROSITE:PS50010}.
FT   DOMAIN      392    494       PH. {ECO:0000259|PROSITE:PS50003}.
FT   DOMAIN      505    554       Phorbol-ester/DAG-type.
FT                                {ECO:0000259|PROSITE:PS50081}.
FT   DOMAIN      555    621       SH3. {ECO:0000259|PROSITE:PS50002}.
FT   DOMAIN      644    738       SH2. {ECO:0000259|PROSITE:PS50001}.
FT   DOMAIN      787    848       SH3. {ECO:0000259|PROSITE:PS50002}.
FT   COILED      241    261       {ECO:0000256|SAM:Coils}.
FT   COILED      277    297       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   849 AA;  98959 MW;  DE96D0CC354211CD CRC64;
     MEEWRQCGRW LIDCKVLPPN HRVVWPSAAV FDLAQALRDG VLLCQMLHNL SPGSVDLKEI
     NFRPQMSQFL CLKNIRTFLK VCHDKFGLRN SELFDPFDLF DFLCLKNIRT FLKVCHDKFG
     LRNSELFDPF DLFDVRDFGK KMGMTEDDKR NCCLVEIQET EAKYYKTLED IEKNYMIPLK
     QFLSPQDMET IFVNLEDVIK VHFALLRAID LNMVSGGSGL GKIFLDFKER LLIYGQYCSH
     MENAQKTLDE LIATREDIKI KVEVSRLLIY GQYCSHMENA QKTLDELIAT REDIKIKVEE
     CTMKVQEGKF KLQDLLVVPM QRVLKYHLLL KELLSHSTDR PERQQLKEAL EAMQDLAMYI
     NEVKRDNETL KKISEFQSSI ENLQVKLEEY GRPKIDGELK VCSIVNRTKQ DRYIFLFDKV
     VIVCKRKGYS YELKEIIELQ SYKMSDDPMN NRDMKKWSYG FYLIHLQGKQ GFQFFCKTEE
     TKRKWMEQFD MAMSNIKPER ATANQHNFQM HTFDKNTNCR ACKMLLRGIF YQGYYCSRCG
     TGAHKECLEV ITICKIRPKM VAVRNYHGTP APVGKTPLCF QTGDFIELLK GDPDTAWWEG
     KLIQTQKSGF FPSSCVKPYL DPKPFQSLCS RQPSREADYY GYPWFAGNME RQQADNLLKS
     HSSGTYLIRE RTAEAERFAI SIKFNDEVKH IKVIEKDSWI HITEAKKFES LLELVEYYQA
     HSLKESFKLL DTTLRYPYKS RERSLTRAST RSPAATCASY NFSFLSPQGL NFSSQSSAPF
     WSVFTPRVVS TAVARYNFAA RDMRELSLRE GDIVKIYSKI GGDQGWWKGE ANGRIGWFPS
     TYVDEEGVQ
//
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