ID A0A0F8B244_LARCR Unreviewed; 432 AA.
AC A0A0F8B244;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Sulfotransferase {ECO:0000256|RuleBase:RU361155};
DE EC=2.8.2.- {ECO:0000256|RuleBase:RU361155};
DE Flags: Fragment;
GN ORFNames=EH28_01262 {ECO:0000313|EMBL:KKF21243.1};
OS Larimichthys crocea (Large yellow croaker) (Pseudosciaena crocea).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Sciaenidae; Larimichthys.
OX NCBI_TaxID=215358 {ECO:0000313|EMBL:KKF21243.1};
RN [1] {ECO:0000313|EMBL:KKF21243.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SSNF {ECO:0000313|EMBL:KKF21243.1};
RC TISSUE=Blood {ECO:0000313|EMBL:KKF21243.1};
RX PubMed=25835551;
RA Ao J., Mu Y., Xiang L.X., Fan D., Feng M., Zhang S., Shi Q., Zhu L.Y.,
RA Li T., Ding Y., Nie L., Li Q., Dong W.R., Jiang L., Sun B., Zhang X.,
RA Li M., Zhang H.Q., Xie S., Zhu Y., Jiang X., Wang X., Mu P., Chen W.,
RA Yue Z., Wang Z., Wang J., Shao J.Z., Chen X.;
RT "Genome Sequencing of the Perciform Fish Larimichthys crocea Provides
RT Insights into Molecular and Genetic Mechanisms of Stress Adaptation.";
RL PLoS Genet. 11:E1005118-E1005118(2015).
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family.
CC {ECO:0000256|RuleBase:RU361155}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KQ041906; KKF21243.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0F8B244; -.
DR eggNOG; KOG3704; Eukaryota.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR GO; GO:0006313; P:DNA transposition; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR037359; NST/OST.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR InterPro; IPR002492; Transposase_Tc1-like.
DR PANTHER; PTHR10605:SF16; HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 1; 1.
DR PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR Pfam; PF01498; HTH_Tnp_Tc3_2; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR637359-3};
KW Transferase {ECO:0000256|RuleBase:RU361155, ECO:0000313|EMBL:KKF21243.1}.
FT DOMAIN 2..49
FT /note="Transposase Tc1-like"
FT /evidence="ECO:0000259|Pfam:PF01498"
FT DOMAIN 180..418
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
FT REGION 148..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..165
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 189
FT /note="For sulfotransferase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-1"
FT BINDING 189..193
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 272
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 280
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 380
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 395..399
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT DISULFID 381..390
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-3"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KKF21243.1"
SQ SEQUENCE 432 AA; 49732 MW; DAD820F8C6470C7D CRC64;
QAQGTSVSDC TIRRCLSQSG FDGRRPSRTP LLKTSHKKAR LEFAKLHVDK PHSFWENVLW
TDETKIELFG KAHQLCSHLF TLLLLTEKRL FFCFSTGPLS SGSCSFNVGY SFGAFARLKS
SRVRTSLMAA LLLGLLLFAM QSPPIPSRPM ADEGPPLPPT SSPTNNPTTS HPNGTLQQFP
QIIIIGVRKG GTRALIEMLS LHSAVAAAQN EVHFFDWESH FEKGLPWYLS QMPYAFPDQL
TVEKTPAYFT SSKVPKRIHQ MNPDIKLLLI LRDPTERVLS DYTQVFYNRL QKHKRYQPIE
SVLVKDGEIN LGYKALNRSL YYVHMQNWLK YFPLKNIHVV DGDELIRDPF PEMKKVERFL
KLESQINASN FYFNKTKGFY CLRDHGRERC LHDSKGRAHP HVAPAILQKL YQFFHEPNKK
FFELVGRTFN WK
//
