ID   A0A0F8B4W0_CERFI        Unreviewed;       333 AA.
AC   A0A0F8B4W0;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=Methylenetetrahydrofolate dehydrogenase [NAD(+)] {ECO:0000313|EMBL:KKF96986.1};
DE            EC=1.5.1.15 {ECO:0000313|EMBL:KKF96986.1};
GN   Name=mtd1 {ECO:0000313|EMBL:KKF96986.1};
GN   ORFNames=CFO_g641 {ECO:0000313|EMBL:KKF96986.1};
OS   Ceratocystis fimbriata f. sp. platani.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Microascales; Ceratocystidaceae; Ceratocystis.
OX   NCBI_TaxID=88771 {ECO:0000313|EMBL:KKF96986.1, ECO:0000313|Proteomes:UP000034841};
RN   [1] {ECO:0000313|EMBL:KKF96986.1, ECO:0000313|Proteomes:UP000034841}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFO {ECO:0000313|EMBL:KKF96986.1,
RC   ECO:0000313|Proteomes:UP000034841};
RA   Belbahri L.;
RT   "Genome sequence of Ceratocystis platani, a major pathogen of plane
RT   trees.";
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KKF96986.1}.
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DR   EMBL; LBBL01000021; KKF96986.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0F8B4W0; -.
DR   Proteomes; UP000034841; Unassembled WGS sequence.
DR   GO; GO:0004487; F:methylenetetrahydrofolate dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd01079; NAD_bind_m-THF_DH; 1.
DR   Gene3D; 3.40.50.10860; Leucine Dehydrogenase, chain A, domain 1; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR   InterPro; IPR035812; m-THF_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR000672; THF_DH/CycHdrlase.
DR   InterPro; IPR020630; THF_DH/CycHdrlase_cat_dom.
DR   InterPro; IPR020631; THF_DH/CycHdrlase_NAD-bd_dom.
DR   PANTHER; PTHR48099; C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED; 1.
DR   PANTHER; PTHR48099:SF3; METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]; 1.
DR   Pfam; PF00763; THF_DHG_CYH; 1.
DR   Pfam; PF02882; THF_DHG_CYH_C; 1.
DR   PRINTS; PR00085; THFDHDRGNASE.
DR   SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW   Oxidoreductase {ECO:0000313|EMBL:KKF96986.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000034841}.
FT   DOMAIN          15..122
FT                   /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT                   catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00763"
FT   DOMAIN          146..212
FT                   /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT                   NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02882"
SQ   SEQUENCE   333 AA;  37114 MW;  EBFA24C706C3EF3C CRC64;
     MAEPTAPVAC KTILANTIAK GLLGEVHQTL ETLGKKPSLV AFLANSDPHA MQYAEWSKKT
     CEENGFDFEL RQVDKEELEE KILEANVDDK VDGIIVYYPI FPGNLMHDKY IQETVALDKD
     VEGLCHTHLH NMYHNVRFLD APTNLKKSIL PCTPLAVVKI MEYLQLYNPL LAYGNRLYGK
     TITIINRSEV NGRPLAALLA NDGATVYSVD ITGVQIFTRG QGIRQVRHQV HDKEGWELKD
     ALPLSDVIIG GVPVESYKIP TDLIREGAVC INFSSFRNFD GPAIKERASI YVPSVGKVTI
     AMLLRNLVRL ITNKADVKRN EEENAEIKTK ASA
//