ID A0A0F8B7I9_LARCR Unreviewed; 222 AA.
AC A0A0F8B7I9;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 22-FEB-2023, entry version 29.
DE RecName: Full=Claudin {ECO:0000256|RuleBase:RU060637};
GN ORFNames=D5F01_LYC00979 {ECO:0000313|EMBL:KAE8300832.1},
GN D5F01_LYC00986 {ECO:0000313|EMBL:KAE8300838.1};
OS Larimichthys crocea (Large yellow croaker) (Pseudosciaena crocea).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Sciaenidae; Larimichthys.
OX NCBI_TaxID=215358 {ECO:0000313|EMBL:KAE8300832.1, ECO:0000313|Proteomes:UP000424527};
RN [1] {ECO:0000313|EMBL:KAE8300832.1, ECO:0000313|Proteomes:UP000424527}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JMULYC20181020 {ECO:0000313|EMBL:KAE8300832.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:KAE8300832.1};
RA Xiao S.;
RT "Chromosome genome assembly for large yellow croaker.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a major role in tight junction-specific obliteration of
CC the intercellular space, through calcium-independent cell-adhesion
CC activity. {ECO:0000256|RuleBase:RU060637}.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|RuleBase:RU060637}. Cell membrane
CC {ECO:0000256|RuleBase:RU060637}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU060637}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the claudin family.
CC {ECO:0000256|ARBA:ARBA00008295, ECO:0000256|RuleBase:RU060637}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU060637}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAE8300832.1}.
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DR EMBL; REGW02000001; KAE8300832.1; -; Genomic_DNA.
DR EMBL; REGW02000001; KAE8300838.1; -; Genomic_DNA.
DR RefSeq; XP_010740343.1; XM_010742041.2.
DR AlphaFoldDB; A0A0F8B7I9; -.
DR GeneID; 104927863; -.
DR KEGG; lco:104927863; -.
DR eggNOG; ENOG502SH48; Eukaryota.
DR OrthoDB; 4040914at2759; -.
DR Proteomes; UP000424527; Unassembled WGS sequence.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.140.150; -; 1.
DR InterPro; IPR006187; Claudin.
DR InterPro; IPR017974; Claudin_CS.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR PANTHER; PTHR12002; CLAUDIN; 1.
DR PANTHER; PTHR12002:SF181; CLAUDIN; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PRINTS; PR01077; CLAUDIN.
DR PROSITE; PS01346; CLAUDIN; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949,
KW ECO:0000256|RuleBase:RU060637};
KW Cell membrane {ECO:0000256|RuleBase:RU060637};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU060637};
KW Reference proteome {ECO:0000313|Proteomes:UP000424527};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427,
KW ECO:0000256|RuleBase:RU060637};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU060637};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU060637}.
FT TRANSMEM 83..102
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU060637"
FT TRANSMEM 122..146
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU060637"
FT TRANSMEM 166..185
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU060637"
SQ SEQUENCE 222 AA; 23140 MW; 20232E4260A90192 CRC64;
MASTGLQLLG LVLAVLGWVF GALVCAAPLW RVSAFVGGEL VIAQMVWEGL WMNCLSQSTG
QIQCKTYDST LALPTSAQAA RGLTVLSLLL CLLALLLGVA GAKCTHCMGD ANQASKARLT
RIAGVLFLVA GLAYLMPICW TAYAIIRDFY DPNVAAPLKR ELGPALYLGW GACVLLLVGG
ALLHVGSSPP GGRTVPVFGG VAKDNPHTGT AGEGKQQEKS FV
//
