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Database: UniProt
Entry: A0A0F8C7G5_9EURY
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ID   A0A0F8C7G5_9EURY        Unreviewed;       433 AA.
AC   A0A0F8C7G5;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   16-JAN-2019, entry version 22.
DE   RecName: Full=Phosphoribosylamine--glycine ligase {ECO:0000256|HAMAP-Rule:MF_00138};
DE            EC=6.3.4.13 {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=GARS {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Glycinamide ribonucleotide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Phosphoribosylglycinamide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
GN   Name=purD {ECO:0000256|HAMAP-Rule:MF_00138};
GN   ORFNames=EO92_05725 {ECO:0000313|EMBL:KKG12197.1};
OS   Methanosarcina sp. 2.H.A.1B.4.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=1483600 {ECO:0000313|EMBL:KKG12197.1, ECO:0000313|Proteomes:UP000034052};
RN   [1] {ECO:0000313|EMBL:KKG12197.1, ECO:0000313|Proteomes:UP000034052}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2.H.A.1B.4 {ECO:0000313|EMBL:KKG12197.1,
RC   ECO:0000313|Proteomes:UP000034052};
RX   PubMed=25756680;
RA   Youngblut N.D., Wirth J.S., Henriksen J.R., Smith M., Simon H.,
RA   Metcalf W.W., Whitaker R.J.;
RT   "Genomic and phenotypic differentiation among Methanosarcina mazei
RT   populations from Columbia River sediment.";
RL   ISME J. 0:0-0(2015).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-phospho-D-ribosylamine + ATP + glycine = ADP + H(+) +
CC         N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate;
CC         Xref=Rhea:RHEA:17453, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:58089,
CC         ChEBI:CHEBI:58457, ChEBI:CHEBI:456216; EC=6.3.4.13;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00138};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-
CC       ribose 1-diphosphate: step 2/2. {ECO:0000256|HAMAP-Rule:MF_00138}.
CC   -!- SIMILARITY: Belongs to the GARS family. {ECO:0000256|HAMAP-
CC       Rule:MF_00138}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KKG12197.1}.
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DR   EMBL; JJOV01000016; KKG12197.1; -; Genomic_DNA.
DR   RefSeq; WP_048169227.1; NZ_JJOV01000016.1.
DR   EnsemblBacteria; KKG12197; KKG12197; EO92_05725.
DR   PATRIC; fig|1483600.3.peg.1261; -.
DR   OrthoDB; 58022at2157; -.
DR   UniPathway; UPA00074; UER00125.
DR   Proteomes; UP000034052; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004637; F:phosphoribosylamine-glycine ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009113; P:purine nucleobase biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   Gene3D; 3.90.600.10; -; 1.
DR   HAMAP; MF_00138; GARS; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR016185; PreATP-grasp_dom_sf.
DR   InterPro; IPR020561; PRibGlycinamid_synth_ATP-grasp.
DR   InterPro; IPR000115; PRibGlycinamide_synth.
DR   InterPro; IPR020560; PRibGlycinamide_synth_C-dom.
DR   InterPro; IPR037123; PRibGlycinamide_synth_C_sf.
DR   InterPro; IPR020559; PRibGlycinamide_synth_CS.
DR   InterPro; IPR020562; PRibGlycinamide_synth_N.
DR   InterPro; IPR011054; Rudment_hybrid_motif.
DR   Pfam; PF01071; GARS_A; 1.
DR   Pfam; PF02843; GARS_C; 1.
DR   Pfam; PF02844; GARS_N; 1.
DR   SMART; SM01210; GARS_C; 1.
DR   SUPFAM; SSF51246; SSF51246; 1.
DR   SUPFAM; SSF52440; SSF52440; 1.
DR   TIGRFAMs; TIGR00877; purD; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS00184; GARS; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Complete proteome {ECO:0000313|Proteomes:UP000034052};
KW   Ligase {ECO:0000256|HAMAP-Rule:MF_00138, ECO:0000313|EMBL:KKG12197.1};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00138}.
FT   DOMAIN      110    317       ATP-grasp. {ECO:0000259|PROSITE:PS50975}.
SQ   SEQUENCE   433 AA;  47063 MW;  359DCB3E42B08A71 CRC64;
     MKILLIGGGG REHAIAEGIK KSKHNPSLYA LMAKKNPGIA ALCEDFLLEK ETEVVKIVEY
     AKARNIEMAF VGPEAPLAAG VADALWEAGI PVVGPRKACA VIEFDKAWAR NFMKKYEIEG
     CPAYEVFTDE VPAHAFIEKL GDVAVKPSGL TGGKGVKVMG DQLPDLKAAR EYTSELLEKG
     SVVIEERFIG EEFTLQAFVD GKNLAFFPAV QDHKRAYEGD LGPNTGGMGS YTDAGEILPF
     MLSEDLEKAK KIMQHTVTAL YEETGTGYQG ILYGQFILTA SGPKVVEFNA RFGDPEAMNV
     IPLIETDFVE IMSAVVKGTL ESLPVKFSRK ATVCKYAVPA GYPDNPEKDS EVVVGDIGEA
     SVYYASVYEK EGRIYTTGSR AVAVVGCAET IEAAEKIAQN ALENIRGKLF FRKDIGTAGL
     IQRRIDHMKE IRG
//
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