ID A0A0F8D2R8_9EURY Unreviewed; 258 AA.
AC A0A0F8D2R8;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Methanol-5-hydroxybenzimidazolylcobamide methyltransferase {ECO:0000313|EMBL:KKG11604.1};
GN ORFNames=EO92_14600 {ECO:0000313|EMBL:KKG11604.1};
OS Methanosarcina sp. 2.H.A.1B.4.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX NCBI_TaxID=1483600 {ECO:0000313|EMBL:KKG11604.1, ECO:0000313|Proteomes:UP000034052};
RN [1] {ECO:0000313|EMBL:KKG11604.1, ECO:0000313|Proteomes:UP000034052}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2.H.A.1B.4 {ECO:0000313|EMBL:KKG11604.1,
RC ECO:0000313|Proteomes:UP000034052};
RX PubMed=25756680;
RA Youngblut N.D., Wirth J.S., Henriksen J.R., Smith M., Simon H.,
RA Metcalf W.W., Whitaker R.J.;
RT "Genomic and phenotypic differentiation among Methanosarcina mazei
RT populations from Columbia River sediment.";
RL ISME J. 0:0-0(2015).
CC -!- SIMILARITY: Belongs to the methylamine corrinoid protein family.
CC {ECO:0000256|ARBA:ARBA00010854}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKG11604.1}.
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DR EMBL; JJOV01000029; KKG11604.1; -; Genomic_DNA.
DR RefSeq; WP_048132713.1; NZ_JJOV01000029.1.
DR AlphaFoldDB; A0A0F8D2R8; -.
DR PATRIC; fig|1483600.3.peg.3222; -.
DR Proteomes; UP000034052; Unassembled WGS sequence.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0050897; F:cobalt ion binding; IEA:InterPro.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0015948; P:methanogenesis; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02070; corrinoid_protein_B12-BD; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 1.10.1240.10; Methionine synthase domain; 1.
DR InterPro; IPR003759; Cbl-bd_cap.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR012741; Corrinoid_p.
DR InterPro; IPR036594; Meth_synthase_dom.
DR NCBIfam; NF040655; MtaC_Meth; 1.
DR NCBIfam; TIGR02370; pyl_corrinoid; 1.
DR PANTHER; PTHR45833; METHIONINE SYNTHASE; 1.
DR PANTHER; PTHR45833:SF1; METHIONINE SYNTHASE; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF02607; B12-binding_2; 1.
DR SMART; SM01018; B12-binding_2; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF47644; Methionine synthase domain; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51337; B12_BINDING_NTER; 1.
PE 3: Inferred from homology;
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000313|EMBL:KKG11604.1};
KW Transferase {ECO:0000313|EMBL:KKG11604.1}.
FT DOMAIN 30..124
FT /note="B12-binding N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51337"
FT DOMAIN 123..258
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
SQ SEQUENCE 258 AA; 27767 MW; 3ED2D10C3D2D24D1 CRC64;
MLDFTEASLK KILTRYNVAL EKEMTPEEAA EELYPKDEFV YPIAKAIFEG EEDDVIEGLQ
AAMDAGQNPI TLIDDALMVG MGVVTKLYDD GVIFLPNVMM SADAMLNGIE FCKENSETAP
VTKGTVVCHV AEGDVHDIGK NIVTALLRAN GYDVVDLGRD VPVDEVVASV IANKPLMVTG
TALMTTTMYA FKEVNDKLVE KGLKVPFACG GGAVNQDFVS QYALGVYGEE AADAPKIADA
IIAGTNNIAA LRDKFHKH
//
