ID A0A0F8D8Y5_CERFI Unreviewed; 638 AA.
AC A0A0F8D8Y5;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 22-FEB-2023, entry version 28.
DE RecName: Full=Phosphoinositide phospholipase C {ECO:0000256|RuleBase:RU361133};
DE EC=3.1.4.11 {ECO:0000256|RuleBase:RU361133};
GN Name=PLC1_2 {ECO:0000313|EMBL:KKF92549.1};
GN ORFNames=CFO_g5100 {ECO:0000313|EMBL:KKF92549.1};
OS Ceratocystis fimbriata f. sp. platani.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Microascales; Ceratocystidaceae; Ceratocystis.
OX NCBI_TaxID=88771 {ECO:0000313|EMBL:KKF92549.1, ECO:0000313|Proteomes:UP000034841};
RN [1] {ECO:0000313|EMBL:KKF92549.1, ECO:0000313|Proteomes:UP000034841}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFO {ECO:0000313|EMBL:KKF92549.1,
RC ECO:0000313|Proteomes:UP000034841};
RA Belbahri L.;
RT "Genome sequence of Ceratocystis platani, a major pathogen of plane
RT trees.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-
CC bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-
CC diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456,
CC ChEBI:CHEBI:203600; EC=3.1.4.11;
CC Evidence={ECO:0000256|RuleBase:RU361133};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKF92549.1}.
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DR EMBL; LBBL01000380; KKF92549.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0F8D8Y5; -.
DR Proteomes; UP000034841; Unassembled WGS sequence.
DR GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:UniProtKB-EC.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR CDD; cd00275; C2_PLC_like; 1.
DR CDD; cd08598; PI-PLC1c_yeast; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001192; PI-PLC_fam.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR InterPro; IPR000909; PLipase_C_PInositol-sp_X_dom.
DR InterPro; IPR001711; PLipase_C_Pinositol-sp_Y.
DR PANTHER; PTHR10336:SF82; PHOSPHOINOSITIDE PHOSPHOLIPASE C; 1.
DR PANTHER; PTHR10336; PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN; 1.
DR Pfam; PF00388; PI-PLC-X; 1.
DR Pfam; PF00387; PI-PLC-Y; 1.
DR PRINTS; PR00390; PHPHLIPASEC.
DR SMART; SM00239; C2; 1.
DR SMART; SM00148; PLCXc; 1.
DR SMART; SM00149; PLCYc; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50007; PIPLC_X_DOMAIN; 1.
DR PROSITE; PS50008; PIPLC_Y_DOMAIN; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|RuleBase:RU361133, ECO:0000313|EMBL:KKF92549.1};
KW Lipid degradation {ECO:0000256|RuleBase:RU361133};
KW Lipid metabolism {ECO:0000256|RuleBase:RU361133};
KW Reference proteome {ECO:0000313|Proteomes:UP000034841};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT DOMAIN 359..472
FT /note="PI-PLC Y-box"
FT /evidence="ECO:0000259|PROSITE:PS50008"
FT DOMAIN 468..616
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 638 AA; 71404 MW; 1BA7C8E1317407AB CRC64;
MSTLHDPRLQ AGGGHSEKER SVSYLNESNL AYLKNIFNYY GKEKDWDRES IANFAQNVQH
DGSRDQCQDS EFWEGKETLD LKSFMEYMAS SNSAATSTRK TDDYSWPLAS YFISSSHNTY
LTGNQLSSDS SADAYRNVLL RGCRCVEVDV WDGEDTDDLS SISSSDDDDE RKHKLKVEEH
RRATKKGKKG GFMSKLKRVA SIKETTSKLE KTTLEDKLAA PIPDLPAPLP EPRVLHGYTL
TKEIYFRDVC EAIAETAFVT SDLPVIVSLE VHCSALQQQA MVDIMKTTWG DMLLLPPGNE
PTCLPTPANL KRKLVVKVKY APPVVEGVAE IPEELSPEEL EASTASGKQI KPSKIIHELS
QLGFNCRGIS FKSLEQEEAV MPTHIFSLSE KAIAEHYQKN GKALLEHNTN FLMRTYPHGL
RIRSGNLEPA SCWRKGAQVV ALNWQNLDEG MMLNEAMYAG TEGYVLKPPG YRSKGIDFPL
ESATRYTYGL TIEVYGAQNI PLPPGDKSDR GFKPYVKIEL HAETPNERLN TGMAEAGDDQ
SYEAEYKARS KTKKGSNADF EGESLEFSNI SGVIEELTFV RFTIRDDEIG SDDLAAWACI
RLDRLREGWR FVHLLDTDGM LTKGVLLVKI TKNKVLGS
//
