ID A0A0F8VT51_9EURO Unreviewed; 1604 AA.
AC A0A0F8VT51;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KKK26411.1};
GN ORFNames=ARAM_002186 {ECO:0000313|EMBL:KKK26411.1};
OS Aspergillus rambellii.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=308745 {ECO:0000313|EMBL:KKK26411.1, ECO:0000313|Proteomes:UP000034291};
RN [1] {ECO:0000313|EMBL:KKK26411.1, ECO:0000313|Proteomes:UP000034291}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SRRC1468 {ECO:0000313|EMBL:KKK26411.1,
RC ECO:0000313|Proteomes:UP000034291};
RA Moore G.G., Beltz S.B., Mack B.M.;
RT "Draft Genome Sequences of Two Closely-Related Aflatoxigenic Aspergillus
RT Species Obtained from the Cote d'Ivoire.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glycine + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage
CC complex H protein] = CO2 + N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-
CC L-lysyl-[glycine-cleavage complex H protein]; Xref=Rhea:RHEA:24304,
CC Rhea:RHEA-COMP:10494, Rhea:RHEA-COMP:10495, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:57305, ChEBI:CHEBI:83099,
CC ChEBI:CHEBI:83143; EC=1.4.4.2;
CC Evidence={ECO:0000256|ARBA:ARBA00043839};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|PIRSR:PIRSR603437-50};
CC -!- PATHWAY: Purine metabolism; guanine degradation; xanthine from guanine:
CC step 1/1. {ECO:0000256|ARBA:ARBA00004984}.
CC -!- SIMILARITY: Belongs to the GcvP family.
CC {ECO:0000256|ARBA:ARBA00010756}.
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC ATZ/TRZ family. {ECO:0000256|ARBA:ARBA00006745}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKK26411.1}.
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DR EMBL; JZBS01000399; KKK26411.1; -; Genomic_DNA.
DR STRING; 308745.A0A0F8VT51; -.
DR OrthoDB; 177349at2759; -.
DR UniPathway; UPA00603; UER00660.
DR Proteomes; UP000034291; Unassembled WGS sequence.
DR GO; GO:0004375; F:glycine dehydrogenase (decarboxylating) activity; IEA:UniProtKB-EC.
DR GO; GO:0008892; F:guanine deaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006546; P:glycine catabolic process; IEA:InterPro.
DR GO; GO:0006147; P:guanine catabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00613; GDC-P; 2.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 2.
DR Gene3D; 2.30.40.10; Urease, subunit C, domain 1; 1.
DR InterPro; IPR006680; Amidohydro-rel.
DR InterPro; IPR003437; GcvP.
DR InterPro; IPR049316; GDC-P_C.
DR InterPro; IPR049315; GDC-P_N.
DR InterPro; IPR020581; GDC_P.
DR InterPro; IPR014311; Guanine_deaminase.
DR InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR InterPro; IPR032466; Metal_Hydrolase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR NCBIfam; TIGR00461; gcvP; 1.
DR NCBIfam; TIGR02967; guan_deamin; 1.
DR PANTHER; PTHR11773:SF1; GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL; 1.
DR PANTHER; PTHR11773; GLYCINE DEHYDROGENASE, DECARBOXYLATING; 1.
DR Pfam; PF01979; Amidohydro_1; 1.
DR Pfam; PF21478; GcvP2_C; 1.
DR Pfam; PF02347; GDC-P; 2.
DR SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 2.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR603437-50};
KW Reference proteome {ECO:0000313|Proteomes:UP000034291}.
FT DOMAIN 79..540
FT /note="Glycine cleavage system P-protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02347"
FT DOMAIN 560..831
FT /note="Glycine cleavage system P-protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02347"
FT DOMAIN 882..1003
FT /note="Glycine dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21478"
FT DOMAIN 1153..1553
FT /note="Amidohydrolase-related"
FT /evidence="ECO:0000259|Pfam:PF01979"
FT MOD_RES 806
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR603437-50"
SQ SEQUENCE 1604 AA; 174187 MW; 9DEE556BD7D64646 CRC64;
MAASWCALRG SRQLALRSRL HPVPSIALRR TTPKTYLPAS RALHTTTTTT RRPVYTSSVA
DHGVPHPRDI FQPLDTFPRR HIGPSPDAAQ EMLATLDPPV ATLDEFVKQV LPADILSQKD
LAVTAPSADT GLPRSSVHGG LGETDMLQLL DQYRKQIDVS GKTYIGAGYY PTIVPPVILR
NILENPAWYT SYTPYQPEIS QGRLESLLNF QTLTADLTGL PFANASVLDE GTAAAEAMTM
SLATLPAAKQ KRPGKAYVVS HLCHPQTIAV MQSRAEGFGI NLVVGDILAN DHQLVKEQGD
NLIGVLAQYP DTEGGVYDYQ GLSDTIHATG GTFSVATDLL ALTVLKAPGE FGADIAFGNA
QRFGVPMGYG GPHAAFFACA DQYKRKVPGR VVGVSKDRLG NRALRLALQT REQHIRREKA
TSNICTAQAL LANMSAMYAV YHGPAGLKAI AQRIMSMTTT LQTQLAALGF HVPIKSNTQD
GATLFDTVVV ELSSRDEADA LVAAARAQSI FLRRVSATKV GVSLDETAGR EDVKNILQVF
ATYATKGEVA LTEPLGLASI PASLARSSAY LTHPVFNTHH SETEMLRYIH HLESKDLSLA
HSMIPLGSCT MKLNATTEMI PVSWPEFSQM HPFLPADVAQ GYTRMIDDLE QQLADITGMA
EVTVQPNSGA QGEFAGLRVI KKYLEANGGS KRNICLIPVS AHGTNPASAA MAGMKVVTIK
CDTKTGNLDL EDLAAKCEKH QEALAAIMIT YPSTFGVYEP GVKQACNLVH QYGGQVYMDG
ANMNAQIGLC SPGEIGADVC HLNLHKTFCI PHGGGGPGVG PIGVAEHLRP FLPSHPASEY
LQAKRSESSS PPISAAPWGS ASILPITFNY INMMGAKGLT HATKITLLNA NYILARLKQH
YPILYTNENG RCAHEFILDV RKFKETCGVE AIDIAKRLQD YGFHAPTMSW PVANTLMIEP
TESENKAELD RFCDALISIR HEIAAVESGA QPRDGNVLKM APHTQRDLLA TEWDRPYARE
TAAYPLPYLL EKKFWPSVTR VDDELIESAL DVEDAIVRSE VQMAPTITFF YGTFVHLPRT
KSGGKHELEI RHGALWVSSA TGRIQGCDWS VSGEEQLQAL IQSQGWVLGA GGGSCEGRVE
IFRAREEQNE FFFPGFIDTH IHAPQYPNSG LFGSSTLLDW LSTYTFPLES SFGDDSLTKA
HAIYNQVISR TLANGTTCAS YFATIHVPAT NLLATLCHRR GQRALIGRVC MDNPDFCPDY
YRDRSAEASL ASTKETITHI HALDPSSKLI HPIITPRFAP TCSRAALASL GALAASHSPP
LHIQTHISEN KDEVTLVHTL FPESTSYADV YDHHGLLTPR TILAHAVHLT PEEKALIGTR
HAKVSHCPAS NSALGSGLCP VRSLLDAGIT VGLGTDVSGG YSPSILEAVR QACLVSRLLR
HSAAPEAEST ANDNRNVLRV EEVLYLATRG GAAVVSMPDD LGGFDPGMFF DAQLIRLGSV
ESVERQPAGS SCLPNETVVD VFGFESWTEK IHKWVWTGDD RNVRRVWVSG RPVHSLEDGP
AEEKKGLGSF SATITSRFLF ARPNPNIVLC FHCKRSKTRA VYKE
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