ID   A0A0F9WTV0_TRIHA        Unreviewed;       626 AA.
AC   A0A0F9WTV0;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE            EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN   ORFNames=THAR02_11324 {ECO:0000313|EMBL:KKO96570.1};
OS   Trichoderma harzianum (Hypocrea lixii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX   NCBI_TaxID=5544 {ECO:0000313|EMBL:KKO96570.1, ECO:0000313|Proteomes:UP000034112};
RN   [1] {ECO:0000313|Proteomes:UP000034112}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T6776 {ECO:0000313|Proteomes:UP000034112};
RX   PubMed=26067977; DOI=10.1128/genomeA.00647-15;
RA   Baroncelli R., Piaggeschi G., Fiorini L., Bertolini E., Zapparata A.,
RA   Pe M.E., Sarrocco S., Vannacci G.;
RT   "Draft whole-genome sequence of the biocontrol agent Trichoderma harzianum
RT   T6776.";
RL   Genome Announc. 3:E0064715-E0064715(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KKO96570.1}.
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DR   EMBL; JOKZ01000835; KKO96570.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0F9WTV0; -.
DR   OMA; PGIRHGH; -.
DR   OrthoDB; 49440at2759; -.
DR   Proteomes; UP000034112; Unassembled WGS sequence.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR   GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   InterPro; IPR000387; Tyr_Pase_dom.
DR   InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR   PANTHER; PTHR10367:SF25; DUAL SPECIFICITY PHOSPHATASE CATALYTIC DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03540); 1.
DR   PANTHER; PTHR10367; MRNA-CAPPING ENZYME; 1.
DR   Pfam; PF00561; Abhydrolase_1; 1.
DR   Pfam; PF00782; DSPc; 1.
DR   SMART; SM00195; DSPc; 1.
DR   SMART; SM00404; PTPc_motif; 1.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW   Reference proteome {ECO:0000313|Proteomes:UP000034112}.
FT   DOMAIN          534..607
FT                   /note="Tyrosine specific protein phosphatases"
FT                   /evidence="ECO:0000259|PROSITE:PS50056"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          317..380
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        326..349
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   626 AA;  69409 MW;  B1148E36816A08E4 CRC64;
     MAKTSPDSPP PEQSLSADPH ETDPALLRHH SHLKAYKTSR FEYPEIRVFY RQHVKADQLP
     KKPAPLPLLV CVPGLGGSVA QFYPLLRSLI DLAPCLAIDW PGGGRSKFAP TQWEAYTSEA
     LMELLEVIIE HHRDKEHDQG VVLIAHSMGT ALSAGLANKK LPHQTALAKH IVGLVAICPV
     SGPMEEAKAT MIKRLFWIPG WIFALWRAWD ARGGLNSTSV SRFVGEDAPT ELRLMQYRYN
     QQSRTPVWRR MAYGALPTRF QDGKAVGGIP GLDAWAGLDI PVFLIGGEKD NVTSPKEIDK
     IAAAFHAMDD AAVSDGIEQA PDASGPDSAE SLSGSTQLDA NTNGNGLTAE DADETDFDES
     ERNSPSTPVE YPPDLPPQSQ HPMRALRSIV LNGSANHTLL YSPRTVRALA GLVSDFLAEH
     ITQRLSLAWQ LQHLSREGKW DVKNLIKWQG VKPVSEPIGP PGKPVFRVIK TLREVDDVHC
     PTVLADNWGN VIKDVIDISK DQPVYDPRGL ERRGIHYHKF PTVSKIPPDG DTVEQFIKLV
     DSVREAQRER AIAEGWADPE QCVVGVHCHY GYNRSGYFVV CYLVEKCGFA LADAIETFKT
     ARPNGIRHSH FLDKLYMRYN LEERAV
//