GenomeNet

Database: UniProt
Entry: A0A0F9WWQ9_TRIHA
LinkDB: A0A0F9WWQ9_TRIHA
Original site: A0A0F9WWQ9_TRIHA 
ID   A0A0F9WWQ9_TRIHA        Unreviewed;       332 AA.
AC   A0A0F9WWQ9;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   22-NOV-2017, entry version 14.
DE   RecName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0000256|RuleBase:RU910714};
DE            Short=HIBADH {ECO:0000256|RuleBase:RU910714};
DE            EC=1.1.1.31 {ECO:0000256|RuleBase:RU910714};
GN   ORFNames=THAR02_10963 {ECO:0000313|EMBL:KKO96929.1};
OS   Trichoderma harzianum (Hypocrea lixii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Hypocreomycetidae; Hypocreales; Hypocreaceae;
OC   Trichoderma.
OX   NCBI_TaxID=5544 {ECO:0000313|EMBL:KKO96929.1, ECO:0000313|Proteomes:UP000034112};
RN   [1] {ECO:0000313|Proteomes:UP000034112}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T6776 {ECO:0000313|Proteomes:UP000034112};
RX   PubMed=26067977; DOI=10.1128/genomeA.00647-15;
RA   Baroncelli R., Piaggeschi G., Fiorini L., Bertolini E., Zapparata A.,
RA   Pe M.E., Sarrocco S., Vannacci G.;
RT   "Draft whole-genome sequence of the biocontrol agent Trichoderma
RT   harzianum T6776.";
RL   Genome Announc. 3:E0064715-E0064715(2015).
CC   -!- CATALYTIC ACTIVITY: 3-hydroxy-2-methylpropanoate + NAD(+) = 2-
CC       methyl-3-oxopropanoate + NADH. {ECO:0000256|RuleBase:RU910714}.
CC   -!- PATHWAY: Amino-acid degradation; L-valine degradation.
CC       {ECO:0000256|RuleBase:RU910714}.
CC   -!- SIMILARITY: Belongs to the 3-hydroxyisobutyrate dehydrogenase
CC       family. {ECO:0000256|RuleBase:RU910714}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KKO96929.1}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; JOKZ01000686; KKO96929.1; -; Genomic_DNA.
DR   EnsemblFungi; KKO96929; KKO96929; THAR02_10963.
DR   UniPathway; UPA00362; -.
DR   Proteomes; UP000034112; Unassembled WGS sequence.
DR   GO; GO:0008442; F:3-hydroxyisobutyrate dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0004616; F:phosphogluconate dehydrogenase (decarboxylating) activity; IEA:InterPro.
DR   GO; GO:0006574; P:valine catabolic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR006115; 6PGDH_NADP-bd.
DR   InterPro; IPR011548; HIBADH.
DR   InterPro; IPR015815; HIBADH-related.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR029154; NADP-bd.
DR   Pfam; PF14833; NAD_binding_11; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   PIRSF; PIRSF000103; HIBADH; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01692; HIBADH; 1.
DR   PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE   3: Inferred from homology;
KW   Branched-chain amino acid catabolism {ECO:0000256|RuleBase:RU910714};
KW   Complete proteome {ECO:0000313|Proteomes:UP000034112};
KW   NAD {ECO:0000256|RuleBase:RU910714};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU910714};
KW   Reference proteome {ECO:0000313|Proteomes:UP000034112}.
FT   DOMAIN       26    196       NAD_binding_2. {ECO:0000259|Pfam:
FT                                PF03446}.
FT   DOMAIN      199    327       NAD_binding_11. {ECO:0000259|Pfam:
FT                                PF14833}.
FT   ACT_SITE    205    205       {ECO:0000256|PIRSR:PIRSR000103-1}.
SQ   SEQUENCE   332 AA;  35375 MW;  CEDE95D69E1D4FC2 CRC64;
     MRVAATRLGS LVQRRGFAST SRRLDNYAFI GLGQMGYQMA RNLQSKLKPT DKVSIFDVNP
     TAVEGLSAEM KAASSGAAVE IAASAHDASK TADTVVTCLP EPQHVRGVYE SILTDSLPKK
     DRIFIDCSTI DPTTSRQVAK SVSEAGQGTF VDAPMSGGVV GATAGTLTFM LGADASILPR
     VEPTLFLMGR KVLHCGDQGA GLSAKLANNY LLALNNIATA EAMNLGIRCG LDPKTLANVL
     NVSTGRCWPS EINNPVKGVI ETAPASRDYR GGFGISLMRK DLRLALVAAE SAQAKTELGT
     LAFDMYDKAA QREDCKDRDF SVVYRYLGGK EE
//
DBGET integrated database retrieval system