ID A0A0F9X142_TRIHA Unreviewed; 531 AA.
AC A0A0F9X142;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Isotrichodermin C-15 hydroxylase {ECO:0000313|EMBL:KKO98409.1};
GN ORFNames=THAR02_09482 {ECO:0000313|EMBL:KKO98409.1};
OS Trichoderma harzianum (Hypocrea lixii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=5544 {ECO:0000313|EMBL:KKO98409.1, ECO:0000313|Proteomes:UP000034112};
RN [1] {ECO:0000313|Proteomes:UP000034112}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T6776 {ECO:0000313|Proteomes:UP000034112};
RX PubMed=26067977; DOI=10.1128/genomeA.00647-15;
RA Baroncelli R., Piaggeschi G., Fiorini L., Bertolini E., Zapparata A.,
RA Pe M.E., Sarrocco S., Vannacci G.;
RT "Draft whole-genome sequence of the biocontrol agent Trichoderma harzianum
RT T6776.";
RL Genome Announc. 3:E0064715-E0064715(2015).
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971};
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKO98409.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JOKZ01000423; KKO98409.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0F9X142; -.
DR OMA; ISWKNGP; -.
DR OrthoDB; 1774992at2759; -.
DR Proteomes; UP000034112; Unassembled WGS sequence.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR CDD; cd11061; CYP67-like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24305; CYTOCHROME P450; 1.
DR PANTHER; PTHR24305:SF242; CYTOCHROME P450 MONOOXYGENASE ATNE-RELATED; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|RuleBase:RU000461};
KW Iron {ECO:0000256|RuleBase:RU000461};
KW Metal-binding {ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW Reference proteome {ECO:0000313|Proteomes:UP000034112}.
SQ SEQUENCE 531 AA; 60257 MW; 6B066D96DFCE087A CRC64;
MGSSHWGISL GLYYMGVCVY RLTLHPLAKY PGPTLAKLTN FYAAYHAFRG DLHLDMWKSH
QKYGKEIIPK SARRVLKYES SGTFVRYGPN RILVNSERGL HDIYGYRKNI QKSKGYLPIL
PAPGAWSVHT AIDKGMHGHK RRVISQGLSD ECIKSFETTY LVHLRRFMNK ILGENTVLDS
EGWTEAINMT PICNHFTFDV MGEFGFGKAF GMLDKPDNHF IIHAIAASNM RTSIYCQFPA
LSKLKLEKIL YPRGSAMRKK FLDLTREFAE QRVSGGKESK NDLFRFVVDA KDPETGQGFS
MAELWAESKF LIVAGSDTSS TVLATLFFYL TRYREVEQKL FEELRTTFSS LEEICLGPKL
LSCTYLRACV DEAMRMNPPA GGAMWREVDN NGAFIDGDFV SPGFDVGTSM YAIHHNEEYY
PESYTYKPER WIESDNNPAK SVQTARNCLN PFSLGPRGCI GRSLALMEIR VALARVVWAF
EMKKPEGALG RVGEGIPEAT NGRHRVNEFQ LVDHLTSDKD GPYIQFRKRH S
//
