ID   A0A0F9X3K2_TRIHA        Unreviewed;       760 AA.
AC   A0A0F9X3K2;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   03-MAY-2023, entry version 26.
DE   SubName: Full=Cullin 1 {ECO:0000313|EMBL:KKO99219.1};
GN   ORFNames=THAR02_08673 {ECO:0000313|EMBL:KKO99219.1};
OS   Trichoderma harzianum (Hypocrea lixii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX   NCBI_TaxID=5544 {ECO:0000313|EMBL:KKO99219.1, ECO:0000313|Proteomes:UP000034112};
RN   [1] {ECO:0000313|Proteomes:UP000034112}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T6776 {ECO:0000313|Proteomes:UP000034112};
RX   PubMed=26067977; DOI=10.1128/genomeA.00647-15;
RA   Baroncelli R., Piaggeschi G., Fiorini L., Bertolini E., Zapparata A.,
RA   Pe M.E., Sarrocco S., Vannacci G.;
RT   "Draft whole-genome sequence of the biocontrol agent Trichoderma harzianum
RT   T6776.";
RL   Genome Announc. 3:E0064715-E0064715(2015).
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KKO99219.1}.
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DR   EMBL; JOKZ01000345; KKO99219.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0F9X3K2; -.
DR   OMA; IREWDRY; -.
DR   OrthoDB; 5474206at2759; -.
DR   Proteomes; UP000034112; Unassembled WGS sequence.
DR   GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016157; Cullin_CS.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF169; CULLIN-1; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS01256; CULLIN_1; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000034112};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          404..636
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
SQ   SEQUENCE   760 AA;  87970 MW;  CFB27BA8103B2EB5 CRC64;
     MGMPAVPNRE DIKATWKYLE DGITRIMNDL EQGMDMQMYM GVYTAVHNFC TSQKAVGLSG
     PTMTTSHRGA HLLGEDLYNH LIKYLQRHLA DLVQASKSHT DEALLAYYIK EWNRYTVAAK
     YIHHLFQYLN RHWVKREIDE GKKNIYDVYT LHLVQWRKVL FEQVSEKVMD AVLKLVEKQR
     NGETIEYGQI KQVVDSFVSL GLDEADPSKS TLDVYRYHFE RPFLAATKEF YQAESKQFVA
     ENTVVEYMKK AEARLAEEEE RVNMYLHQDI ALPLKRCCNQ ALIADHSLSL REEFQVLLDN
     DREEDMARMY NLLSRIPDGL DPLRTRFETH VRKAGLAAVQ KVQSSEGDKL EPKVYVDALL
     EIHTQYQGLV KRAFTDEPEF TRSLDNACRE FVNRNEVCKS GSNKSPELLA KYTDVLLRKS
     TTSIEEADLE RTLSQIMTVF KYIEDKDVFQ KFYSRMLARR LVHSNSSSDD AETSMISKLK
     EACGFEYTNK LQRMFQDMQI SKDLNKEFRD HLETVGNAKA VDSTFSILGT GFWPLTPPST
     HFDPPPEISA EIERFVRFYK HKHDGRKLTW LWHLCKGEIK AGYCKNSKTP YTFQVSIYQM
     SILLLFNEKD SYSYDDISSA TQLSSEVLDQ ALAVILKAKV LLMDGGDKPG PGKTFRLNYD
     FKSKKIRVNL NLGGVKEAKQ EEVETNKTIE EDRKLVLQSA IVRIMKARKK MKHTQLVSET
     INQIRSRFVP KVGDIKKCIE ILLDKEYLER LDDDELGYLA
//