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Database: UniProt
Entry: A0A0F9X8D7_TRIHA
LinkDB: A0A0F9X8D7_TRIHA
Original site: A0A0F9X8D7_TRIHA 
ID   A0A0F9X8D7_TRIHA        Unreviewed;      1527 AA.
AC   A0A0F9X8D7;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   05-JUN-2019, entry version 21.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=THAR02_06395 {ECO:0000313|EMBL:KKP01491.1};
OS   Trichoderma harzianum (Hypocrea lixii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Hypocreomycetidae; Hypocreales; Hypocreaceae;
OC   Trichoderma.
OX   NCBI_TaxID=5544 {ECO:0000313|EMBL:KKP01491.1, ECO:0000313|Proteomes:UP000034112};
RN   [1] {ECO:0000313|Proteomes:UP000034112}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T6776 {ECO:0000313|Proteomes:UP000034112};
RX   PubMed=26067977; DOI=10.1128/genomeA.00647-15;
RA   Baroncelli R., Piaggeschi G., Fiorini L., Bertolini E., Zapparata A.,
RA   Pe M.E., Sarrocco S., Vannacci G.;
RT   "Draft whole-genome sequence of the biocontrol agent Trichoderma
RT   harzianum T6776.";
RL   Genome Announc. 3:E0064715-E0064715(2015).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KKP01491.1}.
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DR   EMBL; JOKZ01000193; KKP01491.1; -; Genomic_DNA.
DR   EnsemblFungi; KKP01491; KKP01491; THAR02_06395.
DR   OrthoDB; 20210at2759; -.
DR   Proteomes; UP000034112; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016035; C:zeta DNA polymerase complex; IEA:InterPro.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0019985; P:translesion synthesis; IEA:InterPro.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR030559; PolZ_Rev3.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   PANTHER; PTHR45812; PTHR45812; 2.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000034112};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000034112};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      668    868       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      936   1381       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN     1422   1495       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION      449    481       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A0F9X8D7}.
FT   REGION      488    507       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A0F9X8D7}.
FT   COILED     1449   1469       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS    488    504       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A0F9X8D7}.
SQ   SEQUENCE   1527 AA;  174106 MW;  94537277F8854421 CRC64;
     MPSIVGAFIY RLHLSIDHAL GISYRRDQYG DKVKYVARIT LVKGIPFYGY SVGYKPFLKI
     YMFNPLVMTR LADLLQQGVI LKRKFQPYEA HLQYLLQFMV DYNLYGCDYI ESSQTYFRFP
     VPAHDANTPT SSHSWNEHTV PAAFITNELT LPRESYCSIE VDIAAQSIAN RGKVKERRLH
     HDFTEFINPP AGDLKLVSSM AGLWKAEARR RQRQMPSGQT LTQHFGSSFP REALVSMSAA
     DSRSFQLQAW MHEEEYRQKV EILISKEREQ CHESELSLDT VLKPLLQEGS IKTALQSVED
     LYPSNILPIL GLSPSAAQPN KDPSSSIEVD EAKLQLSQLD EDDLLAADSD ASDLEQLEQE
     IGMEHGDVPM NIVDHLSLNS RKGEFSKRPE TMGFNMRILG VVESGFSTGQ IPRMPVLSRL
     VEAAQRNQLT YKRGGRAVTS QGIKAVNKRT ASWPPNGNFA KKAKHGAASP EKSSSHLRGA
     DEPNFLYQSQ PLSQSTSIPR SSQRNFKEEG PKAFGHVVTY AIPPPSAADV TWNSEHDLPE
     VIYQDAFYSN EKDLSLRRRE YAGKEFHLIS DTLPFLPEFD PTGNSSQLWS QNAETGLFQK
     ARMRQDDQRL RKICSWRSWE IAQPPPSYEE VAGWLVQNDA ASVTTPKPKL SRPWLSQIDG
     PTPKSKYDFK YSQKQPSSAV PHEAQYMSTM SLEIHVNTRG NFVPNPEEDE IQCIFWHWKD
     DEAMGNATPE VPESSKSGIL VLSRDDILAS PVGSMVPDEV IHESSELDLL NRMVEIVRFY
     DPDILTGYEV HGGSWGYLIE RGRLKYDYDL CNEFSRMKAQ SKGRFGKDSD QWGFNTTSTI
     RVTGRHMINI WRAMRGEVNL LQYTMENVVW HLLQRRIPHY SWKSLTSWYR SGKAQDLNRL
     VKYYRTRTRL DLEILESNEL ISRTSEQARL LGVDFFSVFS RGSQFKVESI MFRIAKPENF
     ILVSPSRKQV GQQNALECLP LVMEPQSAFY SSPLLVLDFQ SLYPSVMIAY NYCYSTFLGR
     ITDWRGKSKM GFAEYKRQDG LLSLLEDHIN IAPNGMMFVK PEVRRSLLAK MLTEILETRI
     MVKSGMKQDK EDKALQQLLN NRQLALKLLA NVTYGYTSAS FSGRMPCSEI ADSIVQTGRE
     TLERATAYIH SVERWGAEVV YGDTDSLFIY LKGRSRDEAF VIGQEIAQAI TERNPKPIKL
     KFEKVYHPCV LLAKKRYVGY KYESKDQTKP EFDAKGIETV RRDGTPAEQK IEEKALRLLF
     ETADLSQVKD YFQKQCEKMM RGKVSIQDFC FAKEVRLGSY VENGLPPAGA MISARKMLQD
     ARAEPQYGER VPYVVITGAP GARLIDRCVS PEELLRNPHW QLDADYYISK NLIPPLERIF
     NLVGANVRQW YDTMPKIRRI HRSQGAGQKK RTLEAYMQSV NCMVCGRKIA STTESSLCRF
     CLARLPASLL MLQSRLTEAE RKYEETLRVC QSCEGIGPLQ DVTCDSHDCP VFWTRTKLKT
     KMLHEQAVTR PMIDELNAKM GGVSLNW
//
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