ID A0A0F9XJW6_TRIHA Unreviewed; 1644 AA.
AC A0A0F9XJW6;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Bloom syndrome protein {ECO:0000313|EMBL:KKP00743.1};
GN ORFNames=THAR02_07169 {ECO:0000313|EMBL:KKP00743.1};
OS Trichoderma harzianum (Hypocrea lixii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=5544 {ECO:0000313|EMBL:KKP00743.1, ECO:0000313|Proteomes:UP000034112};
RN [1] {ECO:0000313|Proteomes:UP000034112}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T6776 {ECO:0000313|Proteomes:UP000034112};
RX PubMed=26067977; DOI=10.1128/genomeA.00647-15;
RA Baroncelli R., Piaggeschi G., Fiorini L., Bertolini E., Zapparata A.,
RA Pe M.E., Sarrocco S., Vannacci G.;
RT "Draft whole-genome sequence of the biocontrol agent Trichoderma harzianum
RT T6776.";
RL Genome Announc. 3:E0064715-E0064715(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKP00743.1}.
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DR EMBL; JOKZ01000233; KKP00743.1; -; Genomic_DNA.
DR OMA; MAINWTT; -.
DR OrthoDB; 5474026at2759; -.
DR Proteomes; UP000034112; Unassembled WGS sequence.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd17920; DEXHc_RecQ; 1.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF105; BLOOM SYNDROME PROTEIN; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000034112}.
FT DOMAIN 775..956
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 987..1130
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 21..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 100..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 207..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 653..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 698..749
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1280..1405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1552..1644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 495..560
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 22..82
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..229
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..324
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..360
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 653..670
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 717..735
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1302..1318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1331..1345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1349..1368
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1552..1572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1592..1620
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1644 AA; 182821 MW; 08A40B53166C3EDF CRC64;
MTRNNLPDNI AWLLKNAALS KPTAPQFPQT SDTASFRFTQ SQSTNGRTAD LSQETTVSAG
SDRRTNQAQG SWSSNGPPKR EEASQNTEVV VLEDDSMGRL SLSTKSRKPV LLSQNVQREA
PSSADGRSKQ VLNESLKPNA IPKSEKQTQN GISPGKQAPS RHNQSPGLDA DFADFDVDDL
EYMDLTRTTG ISDESDEFGE DVKVWAEKDA SWEAPLPKSK KRKSADDAAA DSQFPDVYQL
LGTDPPVPTP SRRTAKKTAQ NASSKMPLPG SSSPLGRVAS RKAPSPVRQT PERDYVISSS
ERRKKVKIAG HRSVSPDSRN IDEDIQQPEQ NQADEFFIPD SDDEFVTPPS RTTTSKKQPM
EPLIDPQEED AFIMDIEDLH VSPQPRRKRS QPPPQRIQAK NLEPSHHNLS ETQSTATADN
VSEINNPQQS FTPSSQTPKL LSLILRNSQL LTKRCEYLNS QIQKNERNFM QAINDRLPKD
KRNEIKAEKE RFIQQQKATQ DLNGLVERYK TLSEQREAVA QQVARSYSNG QDTDEDEARL
DELTERIEAT ERELFQMMNT AGLDEASLLE PLEVPAPSRR DDHIVVLGTQ AGHGGMVNMS
RSSRDVPLPM GGTQVVHQTQ LPEPRPPMNR DLGAEEDLFS DIDDMEMHLL PKPVKKTTQL
DTRKTPQRNR AQRAGNEFSD FSDDADMLAF AQDYEVRQTA GEPSLDPRRA FSETSGNAGP
APKQKQTSKR QPPPDSSQTR IPPELMRHSW SAEVQKTLKD RFRMKGFRQN QLEAINATLA
GDDAFVLMPT GGGKSLCYQL PAVVKSGKTR GVTIVVSPLL SLMQDQVDHM KALGIQAVAF
NSECSPEYKR QVMSAFNERN PEHFIELLYV TPEMASKSPQ FMNALQSLYR SRKFARIVID
EAHCVSQWGH DFRPDYKTLG QLRSKFPQVP VMALTATATQ NVIVDIKHNL GMNNCQVFSQ
SFNRPNLYYE VRPKSSNPVA TQAIAALINS KYPNVTGIVY TISRKQAEDV AQKLSENGIT
ARHYHAAITP AEKVEVQTAW QKGQVKVVVA TIAFGMGIDK PDVRFVMHHG IPKSLEGYYQ
ETGRAGRDGK HSDCILFYGK ADIRVLKRLI IDGEGSKDQK ERQMAMLNRV TAFCDNKADC
RRTEVLRYFG EDFTPSQCHK TCDNCQAGLV FEQQDFSEYA IAAIRIVQQQ QRLTANQCAD
ILIGRKYPDN QEENSYEYHG MAKGMKKHEM VRVIDRLSAE KGFHEENIVG NHGVAIQYLQ
IGPAANQFLS GRRKLMLTVQ VSDSGDSNQT KIKKPRANKK QKEPANNVQS TYVSSPINTR
RKRAAVIDSD DESNLPTTSN GYVNDGFVVS DEEFEDEAEE EMDEDEEAFE PLPQHRPAKP
TTSKPSSKKA LRPEPIPSKR RLQDLPDIHQ DVVDAFVQAA RQLEERIRNG LGLRRPMFTD
THLQEMAINW TTSIERMSRI PGIDVDRVRE VGPKLIQMLN VYHKSYREIA GTGAGEASAS
TSNLDQEIVD LISSDLDIDE DEEEAMGDGE SSHYFVSKPS ADVQAFNDRL QSLNDQPSQS
RGRSSSYSRG GGNRKFSGKR WSKRGGSGGG SQRRGGGSSR RGGGSSSAAG SSSRSGGAGS
SSGGFKRDGR IVKKSGGGIG LMPL
//
