ID A0A0F9XW63_TRIHA Unreviewed; 839 AA.
AC A0A0F9XW63;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Probable beta-glucosidase H {ECO:0000256|ARBA:ARBA00039581};
DE EC=3.2.1.21 {ECO:0000256|ARBA:ARBA00012744};
DE AltName: Full=Beta-D-glucoside glucohydrolase H {ECO:0000256|ARBA:ARBA00041278};
DE AltName: Full=Cellobiase H {ECO:0000256|ARBA:ARBA00041602};
DE AltName: Full=Gentiobiase H {ECO:0000256|ARBA:ARBA00041806};
GN ORFNames=THAR02_03585 {ECO:0000313|EMBL:KKP04308.1};
OS Trichoderma harzianum (Hypocrea lixii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=5544 {ECO:0000313|EMBL:KKP04308.1, ECO:0000313|Proteomes:UP000034112};
RN [1] {ECO:0000313|Proteomes:UP000034112}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T6776 {ECO:0000313|Proteomes:UP000034112};
RX PubMed=26067977; DOI=10.1128/genomeA.00647-15;
RA Baroncelli R., Piaggeschi G., Fiorini L., Bertolini E., Zapparata A.,
RA Pe M.E., Sarrocco S., Vannacci G.;
RT "Draft whole-genome sequence of the biocontrol agent Trichoderma harzianum
RT T6776.";
RL Genome Announc. 3:E0064715-E0064715(2015).
CC -!- FUNCTION: Beta-glucosidases are one of a number of cellulolytic enzymes
CC involved in the degradation of cellulosic biomass. Catalyzes the last
CC step releasing glucose from the inhibitory cellobiose.
CC {ECO:0000256|ARBA:ARBA00024983}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal, non-reducing beta-D-glucosyl residues
CC with release of beta-D-glucose.; EC=3.2.1.21;
CC Evidence={ECO:0000256|ARBA:ARBA00000448};
CC -!- PATHWAY: Glycan metabolism; cellulose degradation.
CC {ECO:0000256|ARBA:ARBA00004987}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 3 family.
CC {ECO:0000256|ARBA:ARBA00005336}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKP04308.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JOKZ01000081; KKP04308.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0F9XW63; -.
DR OMA; DVKHNPA; -.
DR OrthoDB; 5486783at2759; -.
DR Proteomes; UP000034112; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008422; F:beta-glucosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102483; F:scopolin beta-glucosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0000272; P:polysaccharide catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.40.50.1700; Glycoside hydrolase family 3 C-terminal domain; 1.
DR Gene3D; 3.20.20.300; Glycoside hydrolase, family 3, N-terminal domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR026891; Fn3-like.
DR InterPro; IPR002772; Glyco_hydro_3_C.
DR InterPro; IPR036881; Glyco_hydro_3_C_sf.
DR InterPro; IPR001764; Glyco_hydro_3_N.
DR InterPro; IPR036962; Glyco_hydro_3_N_sf.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR037524; PA14/GLEYA.
DR InterPro; IPR011658; PA14_dom.
DR PANTHER; PTHR42715; BETA-GLUCOSIDASE; 1.
DR PANTHER; PTHR42715:SF17; BETA-GLUCOSIDASE H-RELATED; 1.
DR Pfam; PF14310; Fn3-like; 1.
DR Pfam; PF00933; Glyco_hydro_3; 1.
DR Pfam; PF01915; Glyco_hydro_3_C; 1.
DR Pfam; PF07691; PA14; 1.
DR PRINTS; PR00133; GLHYDRLASE3.
DR SMART; SM01217; Fn3_like; 1.
DR SMART; SM00758; PA14; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF52279; Beta-D-glucan exohydrolase, C-terminal domain; 1.
DR PROSITE; PS51820; PA14; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Polysaccharide degradation {ECO:0000256|ARBA:ARBA00023326};
KW Reference proteome {ECO:0000313|Proteomes:UP000034112}.
FT DOMAIN 397..558
FT /note="PA14"
FT /evidence="ECO:0000259|PROSITE:PS51820"
SQ SEQUENCE 839 AA; 91926 MW; 35F40480D81C7839 CRC64;
MGEWQQETKL GFDVETVLAQ LSQNQKIALL SGIDFWHTYP IPEHNVPSVR LTDGPNGIRG
TKFFAGVPAA CLPCGTALAS TWDKQLLRRA GKLLGDECIA KGAHCWLGPT INTPRSPLGG
RGFESFSEDP HLSGILAASM ILGCESTGVI SAVKHFVGND QEHERRAVDC LITPRALREV
YLRPFQIVAR DAKPGALMTS YNKVNGKHVA DSSEMLEELL REEWDWDPLI VSDWYGTYTT
IDAIKAGLDL EMPGVSRYRG KYIESALQAR LLKQSTIDER ARRVLKFAQK AGQLKVSEIE
RGRDFPEDRA LNRQISSSSI VLLKNEDSFL PLPKTNAKVA LIGSHVRLPA ISGGGSASLL
PYYTVSLYDA VSEALPGASI THEVGAYAHQ MLPVISSMLS RAVIHFYNDP ITVTDRKLLG
SENVASTSFQ LMDYNGVPSL NKAMFWGTLL GDFVPTETGT WEFGLSVFGT ANLYIDDELL
IDNTTHQTRG TAFFGKGTTE KIGSKQMVAG STYKLRLEFG SANTTKMETV GMVNFGGGAV
HLGACVKIEP RKMIARAVRA AADADYTIIC TGLNGEWESE GFDRPHMDLP PGVDTMISQV
LDAAPNAVVV NQSGTPVTMK WAHKAKAIVQ AWYGGNETGH GIADVLFGDV NPSGKLSLSW
PVDVKHNPAY LNYASVGGRV LYGEDVYVGY KFYEKTEREV LFPFGHGLSY ATFALSDPVV
KTVPETFRPN QPSVAIVRLK NTSKVAGAQV LQLYISAPNS PTQRPAKELQ GFEKVFLEAG
EEKEVHIPID KYATSFWDEI ENKFKSEEGT YEVLVGVSSQ EILGRGKLVV PETRYWLGL
//
