ID   A0A0F9Y692_TRIHA        Unreviewed;       858 AA.
AC   A0A0F9Y692;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=THAR02_00268 {ECO:0000313|EMBL:KKP07593.1};
OS   Trichoderma harzianum (Hypocrea lixii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX   NCBI_TaxID=5544 {ECO:0000313|EMBL:KKP07593.1, ECO:0000313|Proteomes:UP000034112};
RN   [1] {ECO:0000313|Proteomes:UP000034112}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T6776 {ECO:0000313|Proteomes:UP000034112};
RX   PubMed=26067977; DOI=10.1128/genomeA.00647-15;
RA   Baroncelli R., Piaggeschi G., Fiorini L., Bertolini E., Zapparata A.,
RA   Pe M.E., Sarrocco S., Vannacci G.;
RT   "Draft whole-genome sequence of the biocontrol agent Trichoderma harzianum
RT   T6776.";
RL   Genome Announc. 3:E0064715-E0064715(2015).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KKP07593.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JOKZ01000004; KKP07593.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0F9Y692; -.
DR   OMA; FYLWFFL; -.
DR   OrthoDB; 1967517at2759; -.
DR   Proteomes; UP000034112; Unassembled WGS sequence.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF63; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000034112};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        422..446
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        458..483
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        548..566
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        578..603
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        646..665
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        780..808
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   COILED          101..128
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          279..306
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   858 AA;  97989 MW;  0C932723313C41D8 CRC64;
     MAPRKDTPFR SAEMSMVQLY VSNEIGREVV TALGELGLCQ FRDLNEDVSA FQRTFTQEIR
     RLDNVERQLR YFYAQMEKAG IPLRKLDLDA EKLASPSTSE IDELAERAQK LEQRISALND
     SYETLKKREG DLTEWRWVLR EAGSFFDRAH GNVDEIRAST DNDDAPLLSD IEQHNTAPDV
     ERSFSGMNIG FVAGVINRDR VAAFERILWR TLRGNLYMNQ SEIPEPLIDP TNNEAIQKNV
     FVIFAHGKEI LSKIRKISES MGADVYNVDE NSDLRRDQIH EVNNRLEDVQ NVLRNTQATL
     EAELNQISQS LAPWTVLIAK EKAVYSTLNL LSYDSARRTL IAEAWCPTND MPLIRSTLQD
     VTNRAGLSVP SIVNEIITNK KPPTYLKTNK FTEGFQTIVN AYGTATYQEV NPALPVIVTF
     PFLFAVMFGD LGHAVIMLSA ALAMIYWEKS LKKVSFELFA MIFYGRYIAL VMAVFSVFTG
     LMYNDIFSKS MTLWGSAWEY ERPEHWSEGT PVIATLNDEG YRYPFGLDWA WHGTENNLLF
     TNSYKMKMSI ILGWAHMTYS LCFSYINARH FKKPIDIWGN FIPGMIFFQS IFGYLVVCII
     YKWSVDWNAV GRAPPGLLNM LIYMFLQPGK LDERLYAGQE YVQSILLLLA FVQVPILLFL
     KPFYLRWENN KTRARGYRGL GETSRVSALD GDDENEALVN GHGNSFDDGE GVAMISQNID
     DDEHEEFEFS EVMIHQIIHT IEFCLNCVSH TASYLRLWAL SLAHQQLSVV LWDMTIGPCL
     ATGGVLGVIM IVIGFYLWFF LTIAILVCME GTSAMLHSLR LAWVESFSKF AEFNGWPFAP
     FSFNTLIEES EELKNYLE
//