ID A0A0F9Z5M9_9BACT Unreviewed; 571 AA.
AC A0A0F9Z5M9;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=UR30_C0013G0018 {ECO:0000313|EMBL:KKP38994.1};
OS Candidatus Peregrinibacteria bacterium GW2011_GWC2_33_13.
OC Bacteria; Candidatus Peregrinibacteria.
OX NCBI_TaxID=1619061 {ECO:0000313|EMBL:KKP38994.1, ECO:0000313|Proteomes:UP000034765};
RN [1] {ECO:0000313|EMBL:KKP38994.1, ECO:0000313|Proteomes:UP000034765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKP38994.1}.
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DR EMBL; LBOR01000013; KKP38994.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0F9Z5M9; -.
DR STRING; 1619061.UR30_C0013G0018; -.
DR PATRIC; fig|1619061.3.peg.1082; -.
DR Proteomes; UP000034765; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 1..257
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 258..516
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 21..28
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 571 AA; 67370 MW; C4B401EBC859D2EC CRC64;
MINSNQEKAV KTTDGPVRII AGPGTGKTFT LISRVEYLIR EHKVMPWKIL VISFTNKAAN
ELSFRLSEKE INNVNVTTFH SLAAQMLRKF LNSDFKIIDA ETQKEILKNI LTEDEFKEVN
DILRKLQDSK ESLANIEENR LAEIKKSYQK NLDKNNFLDF YQLLKTFHFL LKNDEIVRSK
CRELFDYIMV DEYQDVNQIQ MDIVNILSEI HQNICIVGDP DQTIYSWRGS DVANMSNFLI
KYNNAKTIFL SENYRTPKLI LEGASNLIKN NKNRLNTNIN AVKEDEHKIN IWNSLYENQL
YEILSTVLEN TFGSHSNMQE ADVLDHNCKE LFCFKDMAIL FRTGHQATRV ASFLSRKGYP
YQIAKDDNFR AKKEIMDFVK ILEYLLDFEK FSADNFEIWL HKKIDDYNSK NKFSEEKRKN
VLNLLSFGFQ FRDFPPKEGL INFLDSIKNM QDSDNIIEAD KINLLTLHAS KGLEFPIVIL
WGLEENNLPL KKHIDDSYFL EEERRLMYVG MTRTKQYLHI FSNKRYGDKI FKKSRFINEI
GDMCFEERIL EQKRENKIRK KEMEKAQMKM F
//
