ID A0A0G0D7Z1_9BACT Unreviewed; 336 AA.
AC A0A0G0D7Z1;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=beta-lactamase {ECO:0000256|ARBA:ARBA00012865};
DE EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865};
GN ORFNames=UR95_C0002G0088 {ECO:0000313|EMBL:KKP90369.1};
OS Parcubacteria group bacterium GW2011_GWC1_36_108.
OC Bacteria.
OX NCBI_TaxID=1618894 {ECO:0000313|EMBL:KKP90369.1, ECO:0000313|Proteomes:UP000034191};
RN [1] {ECO:0000313|EMBL:KKP90369.1, ECO:0000313|Proteomes:UP000034191}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC ChEBI:CHEBI:140347; EC=3.5.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00001526};
CC -!- SIMILARITY: Belongs to the class-A beta-lactamase family.
CC {ECO:0000256|ARBA:ARBA00009009}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKP90369.1}.
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DR EMBL; LBRD01000002; KKP90369.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G0D7Z1; -.
DR STRING; 1618894.UR95_C0002G0088; -.
DR Proteomes; UP000034191; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008800; F:beta-lactamase activity; IEA:InterPro.
DR GO; GO:0030655; P:beta-lactam antibiotic catabolic process; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR045155; Beta-lactam_cat.
DR InterPro; IPR000871; Beta-lactam_class-A.
DR PANTHER; PTHR35333; BETA-LACTAMASE; 1.
DR PANTHER; PTHR35333:SF3; BETA-LACTAMASE2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13354; Beta-lactamase2; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 92..302
FT /note="Beta-lactamase class A catalytic"
FT /evidence="ECO:0000259|Pfam:PF13354"
SQ SEQUENCE 336 AA; 38463 MW; 04F9735703A377F6 CRC64;
MDNKKNKKVA AEFIKSNKKF VVFFLLLLLL ICNVFYWQQQ EKKYAKYLNG DKYVFLNPAS
YLIDADDALV NFQSLRDSLV SKYEKRADYM ISVYFEYLPT GANISINKDE KIWPASLIKI
PVAMAAMKKV SDGKWKLSNE LVILDEDKDN SFGTLFQRPT GTTITIEDTI KQALIQSDNT
AHFMLLRNLD GEELEEVYID LGLDDIINDI KKTPKGEEAD NRMTAKRYSI FFRSLYNASY
LNLEYSQKFL DILGNAPLEY LSNGLPSDVE FVHKTGIRTE DGVRADAGIV YLTDRPYLLT
VMIQKKGENL TIPEGEVEGI FKAISTEIYE YVSQAK
//
