ID A0A0G0FEB4_9BACT Unreviewed; 810 AA.
AC A0A0G0FEB4;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Polymerase protein {ECO:0000313|EMBL:KKP85650.1};
DE Flags: Fragment;
GN ORFNames=UR88_C0011G0001 {ECO:0000313|EMBL:KKP85650.1};
OS Candidatus Nomurabacteria bacterium GW2011_GWA1_35_8.
OC Bacteria; Candidatus Nomurabacteria.
OX NCBI_TaxID=1618727 {ECO:0000313|EMBL:KKP85650.1, ECO:0000313|Proteomes:UP000186383};
RN [1] {ECO:0000313|EMBL:KKP85650.1, ECO:0000313|Proteomes:UP000186383}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKP85650.1}.
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DR EMBL; LBQW01000011; KKP85650.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G0FEB4; -.
DR PATRIC; fig|1618727.3.peg.221; -.
DR Proteomes; UP000186383; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:UniProt.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd08637; DNA_pol_A_pol_I_C; 1.
DR CDD; cd09898; H3TH_53EXO; 1.
DR CDD; cd09859; PIN_53EXO; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR InterPro; IPR002421; 5-3_exonuclease.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR020045; DNA_polI_H3TH.
DR InterPro; IPR002298; DNA_polymerase_A.
DR InterPro; IPR008918; HhH2.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF01367; 5_3_exonuc; 1.
DR Pfam; PF02739; 5_3_exonuc_N; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR PRINTS; PR00868; DNAPOLI.
DR SMART; SM00475; 53EXOc; 1.
DR SMART; SM00279; HhH2; 1.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR PROSITE; PS00447; DNA_POLYMERASE_A; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 29..299
FT /note="5'-3' exonuclease"
FT /evidence="ECO:0000259|SMART:SM00475"
FT DOMAIN 558..767
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KKP85650.1"
SQ SEQUENCE 810 AA; 92097 MW; 0E22C7428FDFDDA7 CRC64;
VYSVFLRQKS PFIIKYNLNG IIYTMAKESK TLVLLDSHAI IHRAYHALPE FLSSKGEPTG
ALYGLSSMLM KIITDLKPDY IVACYDLPQK TFRHEAYEGY KAGRAKTDDA LVLQLKNSRQ
IFEAFNIPVY DSPGFEADDV LGTIVEKLKK DKSINIIIAS GDMDTMQLID GEKVKVYTLK
KGINDTILYN EDKVVDRFGF SPKLLPDYKG LRGDPSDNII GIKGIGEKTA TNLIVNFGTI
EEIYKKVKKE ESIFIKSGIS PRILELIKNN EEEALFSKTL AKIRTDAPIN FTLPRNTFWE
SADLKKIEEM FSVFEFRTLF ARLKSFFGGK LGKESFRAGL AGVGDPENRG PEKTLLSPSS
STELQETSIA LWLINSDISN PSLDDILLFA KTSSFETAHK YIFEQLKEKK LDKVYEEIEK
PIIHIIKNMQ NHGILIDKKY FKNLSEEYHK ELNKLTIKIY KMAGTEFNIN SPKQLGEVIF
GKMGMVLEEL EENNPIIKEI LSYRELQKLL STYIDVIPKM VGEDGRLHAK FLQNGTTTGR
FSSQDPNLQN LPIKTELGKK IRNGFIAEKN YKLLAFDYSQ IELRVAAILS GDKKMTQIFH
EGKDIHTGVA SFVFGVPIEK VDSEMRRKAK VINFGIIYGM GVSSLCKSLG GTRPEAQKFY
DNYFNQFSGI RDYLEGVKVF AMKHYYTETL FGRRRYFPNI NSRIPFLKNM AERTAINAPV
QGTATADIIK LAIRYVEEDL KKANLLDKTH LVLQIHDELV YEVEERVLLE AEKIIKNAMQ
TVLERSYLHY KTSIPLIVHA GLGDNFGEVK
//
