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Database: UniProt
Entry: A0A0G0G3E1_9BACT
LinkDB: A0A0G0G3E1_9BACT
Original site: A0A0G0G3E1_9BACT 
ID   A0A0G0G3E1_9BACT        Unreviewed;       288 AA.
AC   A0A0G0G3E1;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=methylenetetrahydrofolate dehydrogenase (NADP(+)) {ECO:0000256|ARBA:ARBA00012859};
DE            EC=1.5.1.5 {ECO:0000256|ARBA:ARBA00012859};
GN   ORFNames=UR89_C0027G0004 {ECO:0000313|EMBL:KKP86282.1};
OS   Candidatus Roizmanbacteria bacterium GW2011_GWA2_35_8.
OC   Bacteria; Candidatus Roizmanbacteria.
OX   NCBI_TaxID=1618479 {ECO:0000313|EMBL:KKP86282.1, ECO:0000313|Proteomes:UP000034536};
RN   [1] {ECO:0000313|EMBL:KKP86282.1, ECO:0000313|Proteomes:UP000034536}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA   Wilkins M.J., Williams K.H., Banfield J.F.;
RT   "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT   radiation of phyla.";
RL   Nature 0:0-0(2015).
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC       {ECO:0000256|ARBA:ARBA00004777}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KKP86282.1}.
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DR   EMBL; LBQX01000027; KKP86282.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0G0G3E1; -.
DR   Proteomes; UP000034536; Unassembled WGS sequence.
DR   GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.10860; Leucine Dehydrogenase, chain A, domain 1; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR000672; THF_DH/CycHdrlase.
DR   InterPro; IPR020630; THF_DH/CycHdrlase_cat_dom.
DR   InterPro; IPR020631; THF_DH/CycHdrlase_NAD-bd_dom.
DR   PANTHER; PTHR48099:SF5; C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC; 1.
DR   PANTHER; PTHR48099; C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED; 1.
DR   Pfam; PF00763; THF_DHG_CYH; 1.
DR   Pfam; PF02882; THF_DHG_CYH_C; 1.
DR   PRINTS; PR00085; THFDHDRGNASE.
DR   SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Methionine biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Purine biosynthesis {ECO:0000256|ARBA:ARBA00022755}.
FT   DOMAIN          3..116
FT                   /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT                   catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00763"
FT   DOMAIN          165..287
FT                   /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT                   NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02882"
SQ   SEQUENCE   288 AA;  32322 MW;  A4700FEE744157C8 CRC64;
     MKISGLKIAE YLQKVLSHEV IKLGKKHPIK LVVFLAKETP DQLSFVKIKS QMAKKLKVGF
     ELINFKRTPL FQKFAYLLKE RANDISTTGV IIQQPLPQEL STDSIYNYIP QNKEIEGVKK
     KSPFYPAIGL SVLTTIKYIY GDQKLSPSLF IDIKKDRLFF KKLFKNKKVV LVGRGITGGK
     PIGKLLTEVK INYLSINSQT PDAQNYFKNA DLIITAVGQK VLDATMLKPG VVLINVGLRK
     EGNRLKGDYD EDEIKDIAST YTTTPGGVGP IDVVYLYKNL IDAAKLQK
//
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