ID A0A0G0G3E1_9BACT Unreviewed; 288 AA.
AC A0A0G0G3E1;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=methylenetetrahydrofolate dehydrogenase (NADP(+)) {ECO:0000256|ARBA:ARBA00012859};
DE EC=1.5.1.5 {ECO:0000256|ARBA:ARBA00012859};
GN ORFNames=UR89_C0027G0004 {ECO:0000313|EMBL:KKP86282.1};
OS Candidatus Roizmanbacteria bacterium GW2011_GWA2_35_8.
OC Bacteria; Candidatus Roizmanbacteria.
OX NCBI_TaxID=1618479 {ECO:0000313|EMBL:KKP86282.1, ECO:0000313|Proteomes:UP000034536};
RN [1] {ECO:0000313|EMBL:KKP86282.1, ECO:0000313|Proteomes:UP000034536}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKP86282.1}.
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DR EMBL; LBQX01000027; KKP86282.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G0G3E1; -.
DR Proteomes; UP000034536; Unassembled WGS sequence.
DR GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.10860; Leucine Dehydrogenase, chain A, domain 1; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR000672; THF_DH/CycHdrlase.
DR InterPro; IPR020630; THF_DH/CycHdrlase_cat_dom.
DR InterPro; IPR020631; THF_DH/CycHdrlase_NAD-bd_dom.
DR PANTHER; PTHR48099:SF5; C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC; 1.
DR PANTHER; PTHR48099; C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED; 1.
DR Pfam; PF00763; THF_DHG_CYH; 1.
DR Pfam; PF02882; THF_DHG_CYH_C; 1.
DR PRINTS; PR00085; THFDHDRGNASE.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Methionine biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Purine biosynthesis {ECO:0000256|ARBA:ARBA00022755}.
FT DOMAIN 3..116
FT /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00763"
FT DOMAIN 165..287
FT /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF02882"
SQ SEQUENCE 288 AA; 32322 MW; A4700FEE744157C8 CRC64;
MKISGLKIAE YLQKVLSHEV IKLGKKHPIK LVVFLAKETP DQLSFVKIKS QMAKKLKVGF
ELINFKRTPL FQKFAYLLKE RANDISTTGV IIQQPLPQEL STDSIYNYIP QNKEIEGVKK
KSPFYPAIGL SVLTTIKYIY GDQKLSPSLF IDIKKDRLFF KKLFKNKKVV LVGRGITGGK
PIGKLLTEVK INYLSINSQT PDAQNYFKNA DLIITAVGQK VLDATMLKPG VVLINVGLRK
EGNRLKGDYD EDEIKDIAST YTTTPGGVGP IDVVYLYKNL IDAAKLQK
//