ID A0A0G0HIY5_9BACT Unreviewed; 669 AA.
AC A0A0G0HIY5;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=US24_C0006G0007 {ECO:0000313|EMBL:KKQ12034.1};
OS candidate division WS6 bacterium GW2011_GWC2_36_7.
OC Bacteria; Candidatus Dojkabacteria.
OX NCBI_TaxID=1619091 {ECO:0000313|EMBL:KKQ12034.1, ECO:0000313|Proteomes:UP000034075};
RN [1] {ECO:0000313|EMBL:KKQ12034.1, ECO:0000313|Proteomes:UP000034075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKQ12034.1}.
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DR EMBL; LBSF01000006; KKQ12034.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G0HIY5; -.
DR PATRIC; fig|1619091.4.peg.102; -.
DR Proteomes; UP000034075; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 8..291
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 292..585
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 29..36
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 669 AA; 76178 MW; BADFF420207FA341 CRC64;
MNLDIILGGL NPEQKKAVEC TEGPLLVFAG AGSGKTRVIT SRIAYLISEK KVQPQNILAV
TFTKKAAGEM QERIKSILKD IGASIEDLPA VGTFHSIGAL FLRQNAKAVG LTNNFSIYDS
DDSENLIKEL MIERQIDIKQ IKPQSISYLI SAAKNEMVTP ENFGSHYGGY LEDIAAEIYP
AYQKQLKTQN SVDFGDLLYL AVKMLEENEE VRKHYQDKFE YLLIDEYQDT NNAQYKFARL
LSEKHQNICV VGDDDQGIYA WRGADIKNIQ SFEEDFTKVT VIKLEQNYRS TKNVISAAVA
VIQQNNKRVD KKLWTDNNDG ENISVYQARD QEDESEYVTE KIRHMRDMHI PLSNVAILYR
TNYQSRAIEE ALLKTGVPYK LVGGFRFYER KEIKDVISYL RFLYNIKDEL SLGRIINVPS
RKIGPKTVAA LHDLARQADC SIGELLVSAY ALGHPESQAI IDLGGGLLNR VNEVSGELAK
FASLISTFGY LYVEARKKNL LDIIDIILEK TNYIQWFDDG TDQAQMKKEN VTELKNVAYQ
YVKKYPEKSL EMFLNEINLI EQEQDKNQDG SGSYVNLMTL HSSKGLEFDY VFVIGMEEGL
LPHSRAFTDE SELEEERRLC YVGITRAKQK LTLTFAETRL TREGFTSQIP SRFLGEIPQD
ICEYYSWNA
//
