ID A0A0G0HPN5_9BACT Unreviewed; 1020 AA.
AC A0A0G0HPN5;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=US27_C0006G0052 {ECO:0000313|EMBL:KKQ14034.1};
OS Candidatus Moranbacteria bacterium GW2011_GWF1_36_78.
OC Bacteria; Candidatus Moranbacteria.
OX NCBI_TaxID=1618718 {ECO:0000313|EMBL:KKQ14034.1, ECO:0000313|Proteomes:UP000034485};
RN [1] {ECO:0000313|EMBL:KKQ14034.1, ECO:0000313|Proteomes:UP000034485}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKQ14034.1}.
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DR EMBL; LBSI01000006; KKQ14034.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G0HPN5; -.
DR PATRIC; fig|1618718.3.peg.535; -.
DR Proteomes; UP000034485; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR011639; MethylTrfase_TaqI-like_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR025931; TaqI_C.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF07669; Eco57I; 1.
DR Pfam; PF12950; TaqI_C; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 648..737
FT /note="Type II methyltransferase M.TaqI-like"
FT /evidence="ECO:0000259|Pfam:PF07669"
FT DOMAIN 840..960
FT /note="TaqI-like C-terminal specificity"
FT /evidence="ECO:0000259|Pfam:PF12950"
SQ SEQUENCE 1020 AA; 118914 MW; 54F515107E9C6637 CRC64;
MMKFNEKYNP EEFHSFLEDF LPADFAKNEK DIVINKDRYK IITNAKELGF CESLDLYILE
MEHNREKDPR VAITTDAFKI LADHWIHRAL VVFKNNDSEN YRFSYLTISL DINDKNKAIK
KYSNARRYSF YLGVDSKVRT PEQQLIKKGK IQNIDDLFSR FSVEVVNKQF YLEVAKHFDE
LVLSEDKNLV LPSVSQEDVN FRKSFAVRLI GRLMFCWFLK QKKSDKGQLI PDELLSSSIV
ADNYYHNILE PLFFGALNTI IEARDIRSDL FDKVPYLNGG LFNPQSDDYY EVDRGTFTSK
HINTLKISDS WFRNFFELLE TYNFTIDENT VFDQELSVDP EMLGRIFENL LAEINPETGS
SERKRTGSFY TPRQIVEYMV DQSLIEYFKT KTRIDSNKLT ALVSYDLNDD ADYPLSEEEK
MSIVMAIESL KILDPACGSG AYPIGALQKI VYILQLVDPD CKLWLNEKLK GIPELYKQKI
INEVQSNPFD YTRKLDVIKN SIFGVDIQPI AVDVSRLRCF LTLVVESEID DTKPNRGIEP
LPNLDFKFVC ANTLIGLPKL QSNNLFEDHS GVIELSAIMS EYFSCNSQRK NEIRLKFSNT
QKDILNRTVA HYGRSTGELT LKLISWDPFS NNSNSWFDPE WMFGIEEKFD IVIGNPPYVN
LVRIPNEERD IYKKIFTVTK NKVDLYAFFI EKSQELTKEN GTLSFIIPQT WKATDSFLKL
RQFILRHFTI KQIVNLEMGA FTAIVRPLVL LLKKDKEENY KINIYNSNFK HISEININEI
LSKSNFAIDT DSSYSDKSLF NKIESGARPL GEIIQFTRGI KTSDDKRFIG KINKNEEYKR
VFRGRNIKAY ELNWQKEYMQ YRPDLMREKV GCLPHTKKLF EVPMKLVTQR VNSSMQLLVA
IDFDSNYFLD TTNVSRHETL DAKYSMLFLL GLLNSKLINF WYSKNFRMPT IGLYELHSVP
VKETEFAQEK ISKLVKDILQ FKKSGKEKDA KDMQFKIDEL VYELYGLTDE EIKIVEGKNG
//
