ID A0A0G0IN75_9BACT Unreviewed; 418 AA.
AC A0A0G0IN75;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 28-JUN-2023, entry version 32.
DE RecName: Full=S-adenosylmethionine:tRNA ribosyltransferase-isomerase {ECO:0000256|HAMAP-Rule:MF_00113};
DE EC=2.4.99.17 {ECO:0000256|HAMAP-Rule:MF_00113};
DE AltName: Full=Queuosine biosynthesis protein QueA {ECO:0000256|HAMAP-Rule:MF_00113};
GN Name=queA {ECO:0000256|HAMAP-Rule:MF_00113};
GN ORFNames=US75_C0003G0035 {ECO:0000313|EMBL:KKQ56748.1};
OS Candidatus Woesebacteria bacterium GW2011_GWC1_38_13.
OC Bacteria; Candidatus Woesebacteria.
OX NCBI_TaxID=1618583 {ECO:0000313|EMBL:KKQ56748.1, ECO:0000313|Proteomes:UP000034096};
RN [1] {ECO:0000313|EMBL:KKQ56748.1, ECO:0000313|Proteomes:UP000034096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- FUNCTION: Transfers and isomerizes the ribose moiety from AdoMet to the
CC 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give
CC epoxyqueuosine (oQ-tRNA). {ECO:0000256|HAMAP-Rule:MF_00113}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-
CC methionine = adenine + epoxyqueuosine(34) in tRNA + 2 H(+) + L-
CC methionine; Xref=Rhea:RHEA:32155, Rhea:RHEA-COMP:10342, Rhea:RHEA-
CC COMP:18582, ChEBI:CHEBI:15378, ChEBI:CHEBI:16708, ChEBI:CHEBI:57844,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:82833, ChEBI:CHEBI:194443;
CC EC=2.4.99.17; Evidence={ECO:0000256|HAMAP-Rule:MF_00113};
CC -!- PATHWAY: tRNA modification; tRNA-queuosine biosynthesis.
CC {ECO:0000256|HAMAP-Rule:MF_00113}.
CC -!- SUBUNIT: Monomer. {ECO:0000256|HAMAP-Rule:MF_00113}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00113}.
CC -!- SIMILARITY: Belongs to the QueA family. {ECO:0000256|HAMAP-
CC Rule:MF_00113}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKQ56748.1}.
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DR EMBL; LBUE01000003; KKQ56748.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G0IN75; -.
DR STRING; 1618583.US75_C0003G0035; -.
DR PATRIC; fig|1618583.3.peg.191; -.
DR UniPathway; UPA00392; -.
DR Proteomes; UP000034096; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0051075; F:S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0008616; P:queuosine biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 2.40.10.240; QueA-like; 1.
DR Gene3D; 3.40.1780.10; QueA-like; 2.
DR HAMAP; MF_00113; QueA; 1.
DR InterPro; IPR003699; QueA.
DR InterPro; IPR042118; QueA_dom1.
DR InterPro; IPR042119; QueA_dom2.
DR InterPro; IPR036100; QueA_sf.
DR PANTHER; PTHR30307; S-ADENOSYLMETHIONINE:TRNA RIBOSYLTRANSFERASE-ISOMERASE; 1.
DR PANTHER; PTHR30307:SF0; S-ADENOSYLMETHIONINE:TRNA RIBOSYLTRANSFERASE-ISOMERASE; 1.
DR Pfam; PF02547; Queuosine_synth; 1.
DR SUPFAM; SSF111337; QueA-like; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00113};
KW Isomerase {ECO:0000313|EMBL:KKQ56748.1};
KW Queuosine biosynthesis {ECO:0000256|ARBA:ARBA00022785, ECO:0000256|HAMAP-
KW Rule:MF_00113};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691, ECO:0000256|HAMAP-
KW Rule:MF_00113};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_00113}.
SQ SEQUENCE 418 AA; 47837 MW; 0C9FBCE2E3AF1DE8 CRC64;
MDISRFDYQL SRDLIAQKPA DPRDSSRLLV LDRNNGETRH TVFYNIINYL NSNDVLILNK
SKVFPARLYG TKMTKGKVEV LILRFLQNID MDSRLPSFTQ GYGRTQRGDD RVKYRKDKRG
ILRTLSTQDD NTRHSEQSEE SHTICEAITK PGLFLNDRIQ FEGFEGNVKK RDGYITLIEF
DLPHDQLLGK INLIGHTPIP PYINKSPLSE NDLREKYQTV YAKSVGSAAA PTAGLHFTNE
LLKKLRKKGV QTEYVTLHVG LGTFAPVKEK DVEKHKIHEE YFEVDGDTLK RLNKAKKEGK
RIITVGTTTT RVLETLAFGH LSRLGQLEIR NFKDSTNLFI FPPYKFHFVD ALITNFHLPK
STLLALVSAF VSYPNLPAQA GTNKEFTDFR SSSLGRAYNE AIKQKYRFFS FGDAMMIK
//
