ID A0A0G0JPN1_9BACT Unreviewed; 1117 AA.
AC A0A0G0JPN1;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=US89_C0006G0033 {ECO:0000313|EMBL:KKQ68692.1};
OS Candidatus Peregrinibacteria bacterium GW2011_GWF2_38_29.
OC Bacteria; Candidatus Peregrinibacteria.
OX NCBI_TaxID=1619066 {ECO:0000313|EMBL:KKQ68692.1, ECO:0000313|Proteomes:UP000033957};
RN [1] {ECO:0000313|EMBL:KKQ68692.1, ECO:0000313|Proteomes:UP000033957}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKQ68692.1}.
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DR EMBL; LBUS01000006; KKQ68692.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G0JPN1; -.
DR STRING; 1619066.US89_C0006G0033; -.
DR PATRIC; fig|1619066.4.peg.539; -.
DR Proteomes; UP000033957; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:KKQ68692.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}.
FT DOMAIN 555..716
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 737..890
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1094..1117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1117 AA; 126289 MW; E7AD49EB95420430 CRC64;
MIKQNSFVTH FTYPLHNGVI ESFKKNGNLI VSGANGHTSK ALVALDFIEN TDGLPKTFLW
ITDNCIERDI VHKELERLGG VNAVSVDAPM YSSDSFAQKD GVFNGQRSDA INISRFLSKI
VSKVNNFIIV PYYFLMKSFP APGVIRGGVF KITSREEVDM VKTFERLIDI GYEVGDDMQT
LKQGQYFKSG GNMTVWPINS ESLVNIEIDF DKIGKINLLK PISCENEKNV NSVEIYPIIS
SGYTVSITDY IDKNTFVIED ELDIPDDFFD EYNEMSNSLF GDNQYLKFTP FHEDTANHSR
LHYLSITKYR DTFEFTTDLR DKRESGWQIL IFTKNKDELR NIFNEYKLDF SDKVDSFDKD
SGRITFVDVA REDNFPYAFQ NPTLKLALIT DKEISIIRDA KKKAISQKVI LDFLTGLKPG
DFVVHADHGI AKFLGLDQKT IEGITREYLV LGYAENDKLF VPIDQSDKVS KYIGSSDLMP
KLTRLGSVEW TNITNKVKKE TESIAKELLQ LYASRRVAHG IKFKIDDEAQ ARFEEKFPYE
ATPGQIKAFE EVKKKMESPE PMDLLVCGDV GFGKTEVAMR AAFKAVRSGK QVALISPITI
LADQHYRSFT KRMDEFGVRI DMLSRFKTKK EQDVIVKKLE KGELDIVIGT HRLLQPDIKF
KNLGLLVVDE EQRFGVKQKE ALKKLRTEMD ILVLTATPIP RTLNIALNKL RDIVTITTPP
PGRLPVITEV RQFSMTLIRE AILAEVKRGG QMYFLHNRVQ TIDGMADKLR SLVPEARFIV
SHGKLNSDEL EERIIDFKDH KYDVLVTSTI IENGIDLASA NTLIVNHAEK FGLSQLYQLR
GRVGRSRTQA YAYFMYHGQR LPLDAKRRLK AIVEASDLGS GFQIAMKDLE IRGAGDILGV
NQHGVVNVVG VSLFIRMLNK AVEDLKAGRT TDNKDEIPEV SVELPLTAFI PDNYIVSSKD
KINIYQRMSA ADTLQYVGEI KDDVVEEYGQ MPREVLNLFK IIELKLYAKQ AGIVNLKTEN
MHGGKQEIVL YMSDKVKAGN IASLLNYNPK WQISGSKLRV LIKDLGMDWP EELKECLIKL
GKVLLSAATG ADVANPAPNP KPEIQNPKQI PNSNDGV
//