ID A0A0G0KU05_9BACT Unreviewed; 802 AA.
AC A0A0G0KU05;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Polymerase protein {ECO:0000313|EMBL:KKQ82237.1};
GN ORFNames=UT05_C0003G0059 {ECO:0000313|EMBL:KKQ82237.1};
OS Parcubacteria group bacterium GW2011_GWF2_38_76.
OC Bacteria.
OX NCBI_TaxID=1618960 {ECO:0000313|EMBL:KKQ82237.1, ECO:0000313|Proteomes:UP000034258};
RN [1] {ECO:0000313|EMBL:KKQ82237.1, ECO:0000313|Proteomes:UP000034258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKQ82237.1}.
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DR EMBL; LBVI01000003; KKQ82237.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G0KU05; -.
DR STRING; 1618960.UT05_C0003G0059; -.
DR PATRIC; fig|1618960.3.peg.291; -.
DR Proteomes; UP000034258; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:UniProt.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd08637; DNA_pol_A_pol_I_C; 1.
DR CDD; cd09898; H3TH_53EXO; 1.
DR CDD; cd09859; PIN_53EXO; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR InterPro; IPR002421; 5-3_exonuclease.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR020045; DNA_polI_H3TH.
DR InterPro; IPR002298; DNA_polymerase_A.
DR InterPro; IPR008918; HhH2.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF01367; 5_3_exonuc; 1.
DR Pfam; PF02739; 5_3_exonuc_N; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR PRINTS; PR00868; DNAPOLI.
DR SMART; SM00475; 53EXOc; 1.
DR SMART; SM00279; HhH2; 1.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR PROSITE; PS00447; DNA_POLYMERASE_A; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 11..281
FT /note="5'-3' exonuclease"
FT /evidence="ECO:0000259|SMART:SM00475"
FT DOMAIN 551..761
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
SQ SEQUENCE 802 AA; 90970 MW; B8AD4774A4C57CB5 CRC64;
MKTASDKHEF KRRIVLLDVH AILHRAYHAL PDFTTSKGEP TGGLYGLSSM LIKIIGELKP
DYIAACYDLP EPTFRKKLYD AYKAGRKETD TALIDQIIRS RDVFTAFNIP IYEKAGFEAD
DMIGTIAEMA KKEKDLQIVI ASGDLDTTQL IEDEKVVVYT LHKGIKDTII YDEKGIEERY
GFGPKFMADF KGLRGDPSDN IIGIKGIGEK TAETLIKNFG TIEGIYEALK KDENILLKAG
IKARMIELLK EGEEEALFSK NLATIRRDAP IDFSLPKKTW QGGLDMEKVK NLFSVLEFRT
LFGRMEQQLG IFAPTPNLEA SLPSENIDGV NEEIDPLRLK KLFIALWLIN SELTNPKLED
IYAFGETKDI NVAEKKILER IKEDGLERVY YEIELPIIPI IEDAEKRGIL LDVDYLKKLS
EDYHKKHKAL ENKIYELAGT EFNINSPKQM GEILFEKMAL SKKGIRKTAG GAISTKESEL
EKLKDASPIV AEILEYRGIQ KLLSTYIDNL PLLVDEKNRL HTHLNQTGTT TGRMSSTDPN
MQNIPARGEE GSEIRRAILA SPGYKLAAFD YSQIEMRVLA YLTDDETLIQ TFRDGKDIHS
SVASKVFGVP EDKVTKEMRR QAKVINFGII YGMGIKALKK NLGSTMEEAE TFHNNYFEKF
PKVKEYFERI KQEAHDKGYT TTYFGRRRYF PEINSHLPYI RSESERMAMN APIQGTATAD
IIKLAMAHVD GKLREEKLPS DKIHLLLQVH DELVYEVKDD EDIANIVGLI KHAMENVVSI
NLPLLVNAYT GDNWSELKEV KS
//
