ID A0A0G0M851_9BACT Unreviewed; 885 AA.
AC A0A0G0M851;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN ORFNames=US90_C0010G0002 {ECO:0000313|EMBL:KKQ69864.1};
OS Candidatus Shapirobacteria bacterium GW2011_GWE2_38_30.
OC Bacteria; Candidatus Shapirobacteria.
OX NCBI_TaxID=1618490 {ECO:0000313|EMBL:KKQ69864.1, ECO:0000313|Proteomes:UP000034406};
RN [1] {ECO:0000313|EMBL:KKQ69864.1, ECO:0000313|Proteomes:UP000034406}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKQ69864.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LBUT01000010; KKQ69864.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G0M851; -.
DR STRING; 1618490.US90_C0010G0002; -.
DR PATRIC; fig|1618490.4.peg.456; -.
DR Proteomes; UP000034406; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF33; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; 1.
DR Pfam; PF17957; Big_7; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 39..65
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 90..266
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 345..632
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 885 AA; 98794 MW; B177C876CF60F02E CRC64;
MKRKLKLFYF RFKKRCEQLK WNLSEYMRKK GIKLNKKRLA YWFVLAFFGL TIVGFLGSFI
VFAWFSKDLP TPSKVVRREG YASRIYDRNG ELLYDVYKDS KRTPVESIDD IPKYLREAVV
AVEDKDFYKH QGFDPLAPFR IIKNVFVLHR LTGGSTLTQQ LVKNVLLTSD RTITRKIKEF
ILAVQIEKKY SKDEILLMYL NESPYGGPFW GVGTASEQYF DKKVKDLDLV ESVILAGIPQ
RPNVYSPFSG TPQAYSERAA HVLERMREDG YISSELEKET LEKVKKYKFN ENSSQILAPH
FVFWVKVEGG GLKITTTLDL KLQQETQKIV TEEIDKAESK GISNGAAIVV DPINGQVLAM
VGSRGYFSDK TDGKYNVVTA GLRQPGSAIK PVTYLVAIKK GWTAASMIMD VPVTFPGVGG
QKDYSPNNYN GKFNGPMSLR NALGNSINTI AVKMLANVGI KNMLQQAYDM GMTTLEPTAE
NLSRFGLAVT LGGAEVRMSE LAAGYSSFAN GGKRVDLVGV LKVEDGDGKV LEEYKEVAGK
QVMTPQEAFI INNILSDNSA RELTFGAVNS LVISNYQVAV KTGTTNDKRD NWAIGWTPNL
LTAVWVGNND NSEMKSVASG VSGATPIWQR IMKFEIPKRQ KQDFSIPDRI VNMQVDALSG
YAAHDGFPSR SDYFIDGTQP RITDPIHMKL KVCKGVSGLA TPEDVARGNY DEKEFIKLSE
NDPISKDGKN RWQEGIDNWI LQQPDKDKYY PPSGYCRDDG MLDVGFESPS NQSTVGNEVQ
VKITTSSLVK VTEVKLWVDG EEKKTWGEKP YETTINLADG PHSLKVKATD REGNTNEKEI
KIGVNVAWDW KPAPVVTNTP IPSPTRILSP TLIPSLIPTG IGLTL
//
