ID A0A0G0MNW3_9BACT Unreviewed; 725 AA.
AC A0A0G0MNW3;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=UT30_C0003G0002 {ECO:0000313|EMBL:KKR04813.1};
OS Candidatus Uhrbacteria bacterium GW2011_GWF2_39_13.
OC Bacteria; Candidatus Uhrbacteria.
OX NCBI_TaxID=1618995 {ECO:0000313|EMBL:KKR04813.1, ECO:0000313|Proteomes:UP000033935};
RN [1] {ECO:0000313|EMBL:KKR04813.1, ECO:0000313|Proteomes:UP000033935}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKR04813.1}.
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DR EMBL; LBWG01000003; KKR04813.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G0MNW3; -.
DR PATRIC; fig|1618995.3.peg.161; -.
DR Proteomes; UP000033935; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF3; ATP-DEPENDENT HELICASE_DEOXYRIBONUCLEASE SUBUNIT B; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 45..329
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 330..593
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 66..73
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 725 AA; 82164 MW; B9EC15E769FF8DF3 CRC64;
MSFCDGDGPF SGVVFSIRML ECARMQEFTL HDNFDLSKAR IDYQKELNPQ QLEVVLNGEG
AVLVLAGAGS GKTRTITYRV SYLLERGVSP DNILLLTFTN KAAKEMLSRV ETLLGWYPKG
LWGGTFHSIA NRLLRIYAPE LGYPSNFTIL DQEDTKALVK VCIKLLQVDT TSRRFPSPSK
VHSLISYVHN SGKSISEVIE SKYPQLTELT GVIERIAQLY AQRKKEADAM DFDDLLLKLR
ELLSTNEGIR RRLSQQFEYV LVDEYQDTNV VQADLIRFLS SEHGNLLVVG DDAQSIYSFR
AADIKNILGF PQTYPKTKTF RLTTNYRSTP EILSIANAII AQNKNQFKKE LASVQPSSDL
PHLVPANNSA QEAQFISQRI LVLREEGVPL KEVAVLFRAA FHSQALEFEL MKRDIPYEYR
GGLKFFERAH IKDVISYLRI KTNPKDEMAW MRVLGLLSGV GLATAQNIAV QMKKLNSLAD
LFSSPIKIPK RAQSGWNLLL KTVEDLVAGN LPSDLIRTVV AGDYRNYLEA EYPDFMDRLE
DLEQFALFAQ GYTSLQVFLD EISLSLDYGV LREEDGISEE EKIVLSTIHQ AKGLEWTAVF
VMHLIDGKFP NERALEEEGG LEEERRLFYV ATTRARKQLF FTYPITSGYD TLMLSQPSIF
LQELPDTLFE KILLKTAVKS FASHSSSNKQ SWDDEGPTIV FDELGERVQK QIPKGMSFLR
NIDEL
//
