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Database: UniProt
Entry: A0A0G0MZX0_9BACT
LinkDB: A0A0G0MZX0_9BACT
Original site: A0A0G0MZX0_9BACT 
ID   A0A0G0MZX0_9BACT        Unreviewed;       568 AA.
AC   A0A0G0MZX0;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   08-MAY-2019, entry version 19.
DE   RecName: Full=Prephenate dehydratase {ECO:0000256|RuleBase:RU361254};
DE            Short=PDT {ECO:0000256|RuleBase:RU361254};
DE            EC=4.2.1.51 {ECO:0000256|RuleBase:RU361254};
GN   Name=tyrA {ECO:0000313|EMBL:KKR08718.1};
GN   Synonyms=pheA {ECO:0000256|RuleBase:RU361254};
GN   ORFNames=UT36_C0005G0089 {ECO:0000313|EMBL:KKR08718.1};
OS   Candidatus Peregrinibacteria bacterium GW2011_GWF2_39_17.
OC   Bacteria; Candidatus Peregrinibacteria.
OX   NCBI_TaxID=1619067 {ECO:0000313|EMBL:KKR08718.1, ECO:0000313|Proteomes:UP000034818};
RN   [1] {ECO:0000313|EMBL:KKR08718.1, ECO:0000313|Proteomes:UP000034818}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA   Wilkins M.J., Williams K.H., Banfield J.F.;
RT   "rRNA introns, odd ribosomes, and small enigmatic genomes across a
RT   large radiation of phyla.";
RL   Nature 0:0-0(2015).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC         Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934;
CC         EC=4.2.1.51; Evidence={ECO:0000256|RuleBase:RU361254};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC       phenylpyruvate from prephenate: step 1/1.
CC       {ECO:0000256|RuleBase:RU361254}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KKR08718.1}.
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DR   EMBL; LBWM01000005; KKR08718.1; -; Genomic_DNA.
DR   EnsemblBacteria; KKR08718; KKR08718; UT36_C0005G0089.
DR   PATRIC; fig|1619067.4.peg.648; -.
DR   UniPathway; UPA00121; UER00345.
DR   Proteomes; UP000034818; Unassembled WGS sequence.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:InterPro.
DR   GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006571; P:tyrosine biosynthetic process; IEA:InterPro.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR001086; Preph_deHydtase.
DR   InterPro; IPR018528; Preph_deHydtase_CS.
DR   InterPro; IPR003099; Prephen_DH.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF02153; PDH; 1.
DR   Pfam; PF00800; PDT; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS51176; PDH_ADH; 1.
DR   PROSITE; PS00858; PREPHENATE_DEHYDR_2; 1.
DR   PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Aromatic amino acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Complete proteome {ECO:0000313|Proteomes:UP000034818};
KW   Isomerase {ECO:0000313|EMBL:KKR08718.1};
KW   Lyase {ECO:0000256|RuleBase:RU361254};
KW   Oxidoreductase {ECO:0000313|EMBL:KKR08718.1};
KW   Phenylalanine biosynthesis {ECO:0000256|RuleBase:RU361254}.
FT   DOMAIN        1    263       Prephenate/arogenate dehydrogenase.
FT                                {ECO:0000259|PROSITE:PS51176}.
FT   DOMAIN      286    465       Prephenate dehydratase.
FT                                {ECO:0000259|PROSITE:PS51171}.
FT   DOMAIN      480    560       ACT. {ECO:0000259|PROSITE:PS51671}.
SQ   SEQUENCE   568 AA;  63371 MW;  83023791FD4050E7 CRC64;
     MNVGIFGGNG RMGTAFASFF KNLGFQVFIA DKGSKYSNIE VAKLAEVLIV AVPIDKTENV
     IKEINPYVRK KALLMDVTSI KEQPVKAMLK SKAAVIGMHP MFNETTFGFG QKILYSPARP
     GKWLPWFLDV FGEKGGFKLI KISPKKHDQI MAFAQTLVHF TDFALAKTLS RLGPNLSELL
     SLASPASCLR VKIAARHLAQ DAKLYGNIQF QNLQNRAVLK IFEEEVQELF RIVTKHDLGR
     FIAYFNQGKK YFGNYGKMAI KETDVLIQRM IGVGKLPTAQ PLPKKAIATL GPSLTYSSFA
     ALKWKGKKGN FVVYFNSIEE IFEAVESGKV LYGVVPLENR LQGTIRETHD CLFKHRVYLV
     DELRLDIHHC LAVLPGVDLK HIQQIVSHPQ ALNQCSLYLR KYFPKAEWIT VSSTAAAFEY
     IRQAGDEGMA AIGSKEAAKH FKFKIAGRAI ENDSSNVTDF IVISSEKPKA QPFRKAKTSL
     VFYFQENKPG SLFAVFEVFA DLGINLSRIE SRPAPKELGE YLFFVDIEEN ADSKKGRMAL
     NEVRKIVSGL KILGIVTLPP GGHRPPSS
//
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